CD4+ Vα14 natural killer T cells are essential for acceptance of rat islet xenografts in mice

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

CD1d-Restricted and TCR-Mediated Activation of V _α 14 NKT Cells by Glycosylceramides

1997 • 2,370 citations

MOUSE CD1-SPECIFIC NK1 T CELLS: Development, Specificity, and Function

1997 • 1,326 citations

Requirement for V _α 14 NKT Cells in IL-12-Mediated Rejection of Tumors

1997 • 1,226 citations

Disruption of the murine IL-4 gene blocks Th2 cytokine responses

1993 • 1,197 citations

Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen‐Reactivity

1983 • 1,040 citations

CD1 Recognition by Mouse NK1 ⁺ T Lymphocytes

1995 • 903 citations

CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.

1994 • 862 citations

CD1d-mediated Recognition of an α-Galactosylceramide by Natural Killer T Cells Is Highly Conserved through Mammalian Evolution

1998 • 649 citations

Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes

1998 • 642 citations

Role of NK1.1 ⁺ T Cells in a T _H 2 Response and in Immunoglobulin E Production

1995 • 508 citations

Immunoglobulin E Production in the Absence of Interleukin-4-Secreting CD1-Dependent Cells

1997 • 501 citations

Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Vα14 NKT cells

1998 • 474 citations

CD1d-restricted Recognition of Synthetic Glycolipid Antigens by Human Natural Killer T Cells

1998 • 445 citations

Suppression of concanavalin A-induced hepatitis in IFN-gamma(-/-) mice, but not in TNF-alpha(-/-) mice: role for IFN-gamma in activating apoptosis of hepatocytes.

1997 • 398 citations

Augmentation of Vα14 Nkt Cell–Mediated Cytotoxicity by Interleukin 4 in an Autocrine Mechanism Resulting in the Development of Concanavalin a–Induced Hepatitis

2000 • 395 citations

Cutting edge: activation of NK T cells by CD1d and alpha-galactosylceramide directs conventional T cells to the acquisition of a Th2 phenotype.

1999 • 359 citations

NK1.1+ T cell receptor-alpha/beta+ cells: new clues to their origin, specificity, and function.

1995 • 355 citations

Tissue-Specific Segregation of CD1d-Dependent and CD1d-Independent NK T Cells

1999 • 332 citations

Selective reduction of T cells bearing invariant V alpha 24J alpha Q antigen receptor in patients with systemic sclerosis.

1995 • 310 citations

Induction of tolerance by monoclonal antibody therapy

1986 • 307 citations

Immunization with α-galactosylceramide polarizes CD1-reactive NK T cells towards Th2 cytokine synthesis

1999 • 306 citations

Cutting Edge: Activation of NK T Cells by CD1d and α-Galactosylceramide Directs Conventional T Cells to the Acquisition of a Th2 Phenotype

1999 • 296 citations

Selective reduction of V alpha 14+ NK T cells associated with disease development in autoimmune-prone mice.

1996 • 290 citations

NK1.1⁺ CD4⁺ CD8‐ thymocytes with specific lymphokine secretion

1993 • 265 citations

Association Between αβTCR+CD4−CD8− T-Cell Deficiency and IDDM in NOD/Lt Mice

1997 • 258 citations

ISOLATION OF RAT PANCREATIC ISLETS BY DUCTAL INJECTION OF COLLAGENASE1

1986 • 256 citations

Predominant expression of invariant V_α14⁺ TCR α chain in NK1.1⁺ T cell populations

1995 • 243 citations

Defective IgE production by SJL mice is linked to the absence of CD4+, NK1.1+ T cells that promptly produce interleukin 4.

1995 • 237 citations

Beta 2-microglobulin-dependent NK1.1+ T cells are not essential for T helper cell 2 immune responses.

1996 • 207 citations

Selective development of T helper (Th)2 cells induced by continuous administration of low dose soluble proteins to normal and beta(2)-microglobulin-deficient BALB/c mice.

1996 • 198 citations

Mechanisms of Peripheral Tolerance and Suppression Induced by Monoclonal Antibodies to CD4 and CD8

1996 • 195 citations

Islet Allograft Survival After a Single Course of Treatment of Recipient with Antibody to L3T4

1987 • 179 citations

Details of an isolation method for hepatic lymphocytes in mice

1992 • 169 citations

Cytokine production by mature and immature CD4-CD8- T cells. Alpha beta-T cell receptor+ CD4-CD8- T cells produce IL-4.

1992 • 167 citations

Transplantation of Isolated Pancreatic Islets into the Portal Vein of Diabetic Rats

1973 • 164 citations

Inhibition of T Helper Cell Type 2 Cell Differentiation and Immunoglobulin E Response by Ligand-Activated Vα14 Natural Killer T Cells

1999 • 158 citations

CD4+ and CD8+ T cells acquire specific lymphokine secretion potentials during thymic maturation

1991 • 155 citations

T cell responses in calcineurin A alpha-deficient mice.

1996 • 149 citations

EFFECT OF GK1.5 MONOCLONAL ANTIBODY DOSAGE ON SURVIVAL OF PIG PROISLET XENOGRAFTS IN CD4+ T CELL-DEPLETED MICE

1990 • 118 citations

Sequence and expression of transcripts of the T-cell antigen receptor alpha-chain gene in a functional, antigen-specific suppressor-T-cell hybridoma.

1986 • 118 citations

A novel cell type responsible for marrow graft rejection in mice. T cells with NK phenotype cause acute rejection of marrow grafts.

1989 • 93 citations

Induction of immune tolerance during administration of monoclonal antibody to L3T4 does not depend on depletion of L3T4+ cells.

1988 • 84 citations

EVIDENCE THAT LONG-TERM CARDIAC ALLOGRAFT SURVIVAL INDUCED BY ANTI-CD4 MONOCLONAL ANTIBODY DOES NOT REQUIRE DEPLETION OF CD4+ T CELLS

1992 • 82 citations

Simple Method for the Collection of Pancreatic Islets by the Use of Ficoll-Conray Gradient

1979 • 81 citations

A novel recognition motif of human NKT antigen receptor for a glycolipid ligand

1999 • 67 citations

IL-4-Producing NK1.1+ T Cells Are Resistant to Glucocorticoid-Induced Apoptosis: Implications for the Th1/Th2 Balance

1998 • 65 citations

Evidence for extrathymic development of TNK cells. NK1+ CD3+ cells responsible for acute marrow graft rejection are present in thymus-deficient mice.

1992 • 64 citations

CD4 MONOCLONAL ANTIBODIES IN ORGAN TRANSPLANTATION—A REVIEW OF PROGRESS1

1991 • 58 citations

EFFECT OF TRANSPLANTATION SITE AND αL3T4 TREATMENT ON SURVIVAL OF RAT, HAMSTER, AND RABBIT ISLET XENOGRAFTS IN MICE

1989 • 51 citations

DONOR ANTIGEN-PRESENTING CELL–INDEPENDENT REJECTION OF ISLET XENOGRAFTS

1995 • 47 citations

Transplant Rejection

1993 • 42 citations

ISLET ALLOGRAFT, ISLET XENOGRAFT, AND SKIN ALLOGRAFT SURVIVAL IN CD8

1993 • 42 citations

NONDEPLETING ANTI-CD4 ANTIBODIES IN TRANSPLANTATION

1994 • 40 citations

NONDEPLETING ANTI-CD4 ANTIBODIES IN TRANSPLANTATION

1994 • 36 citations

Radioresistance of Intermediate TCR Cells and Their Localization in the Body of Mice Revealed by Irradiation

1993 • 26 citations

USE OF ANTI-L3T4 AND ANTI-Ia TREATMENTS FOR PROLONGATION OF XENOGENEIC ISLET TRANSPLANTS

1988 • 21 citations

Vα14+ NK T cells: A novel lymphoid cell lineage with regulatory function

1996 • 20 citations

Rejection of pancreatic islet xenografts does not require CD8+ T-lymphocytes.

1992 • 16 citations

Evidence for differentiation of NK1+ cells into cytotoxic T cells during acute rejection of allogeneic bone marrow grafts

1990 • 12 citations