The role of TGF-β in digestive organ disease

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Cutaneous Wound Healing

1999 • 5,878 citations

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Role of Transforming Growth Factor β in Human Disease

2000 • 2,405 citations

TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders

2000 • 2,354 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

TGF-β signaling in tumor suppression and cancer progression

2001 • 2,235 citations

NEW EMBO MEMBERS REVIEW: Transcriptional control by the TGF-beta/Smad signaling system

2000 • 1,935 citations

REGULATION OF IMMUNE RESPONSES BY TGF-β

1998 • 1,908 citations

Controlling TGF-beta signaling.

2000 • 1,806 citations

Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

1997 • 1,774 citations

Growth factors from murine sarcoma virus-transformed cells.

1978 • 1,457 citations

Smad6 inhibits signalling by the TGF-β superfamily

1997 • 1,026 citations

Mutations in the SMAD4/DPC4 Gene in Juvenile Polyposis

1998 • 901 citations

The Transforming Growth Factor-βs

1991 • 882 citations

MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma

1996 • 855 citations

Roles of TGF-beta in hepatic fibrosis

2002 • 794 citations

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription

1998 • 789 citations

Transforming growth factor-beta: Vasculogenesis, angiogenesis, and vessel wall integrity

1997 • 715 citations

Smad3 Mutant Mice Develop Metastatic Colorectal Cancer

1998 • 677 citations

Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions.

1995 • 668 citations

Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex.

1990 • 647 citations

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

1996 • 614 citations

Intestinal Tumorigenesis in Compound Mutant Mice of both Dpc4(Smad4) and Apc Genes

1998 • 603 citations

Blocking Smad7 restores TGF-β1 signaling in chronic inflammatory bowel disease

2001 • 571 citations

A Smad Transcriptional Corepressor

1999 • 563 citations

Mechanisms of TGF-β signaling in regulation of cell growth and differentiation

2002 • 521 citations

Smad2 and Smad3 Positively and Negatively Regulate TGFβ-Dependent Transcription through the Forkhead DNA-Binding Protein FAST2

1998 • 513 citations

Smads and early developmental signaling by the TGFβ superfamily

1998 • 485 citations

Cytokines in Inflammatory Bowel Disease

1998 • 481 citations

A transforming growth factor beta receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability.

1995 • 445 citations

Functional Analysis of the Transforming Growth Factor βResponsive Elements in the WAF1/Cip1/p21 Promoter

1995 • 440 citations

Sustained expression of TGF-β1 underlies development of progressive kidney fibrosis

1994 • 413 citations

Mechanisms of TGF-β-mediated apoptosis

2002 • 397 citations

Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers.

1999 • 395 citations

Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease

1996 • 388 citations

Ubiquitin-dependent degradation of TGF-β-activated Smad2

1999 • 343 citations

Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta.

1994 • 324 citations

Identification of regulatory sequences in the type 1 plasminogen activator inhibitor gene responsive to transforming growth factor beta.

1991 • 324 citations

The SMAD4 protein and prognosis of pancreatic ductal adenocarcinoma.

2001 • 295 citations

Frequency of Smad gene mutations in human cancers.

1997 • 289 citations

High levels of transforming growth factor beta 1 in patients with colorectal cancer: Association with disease progression

1996 • 285 citations

Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas.

1998 • 284 citations

The TGF-β signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer

1999 • 259 citations

Transforming Growth Factor β Activates the Promoter of Cyclin-dependent Kinase Inhibitor p15 through an Sp1 Consensus Site

1995 • 249 citations

Mutation of the type II transforming growth factor-beta receptor is coincident with the transformation of human colon adenomas to malignant carcinomas.

1998 • 249 citations

VEGF, basic-FGF, and TGF-beta in Crohn's disease and ulcerative colitis: a novel mechanism of chronic intestinal inflammation

2001 • 229 citations

Multiple Modes of Repression by the Smad Transcriptional Corepressor TGIF

1999 • 204 citations

Disruption of the antiproliferative TGF-β signaling pathways in human pancreatic cancer cells

1998 • 190 citations

Critical Role of Smads and AP-1 Complex in Transforming Growth Factor-β-dependent Apoptosis

2000 • 186 citations

Receptors for Transforming Growth Factor-β

1993 • 181 citations

High levels of transforming growth factor beta 1 correlate with disease progression in human colon cancer.

1995 • 179 citations

Genomic instability in the type II TGF-beta1 receptor gene in atherosclerotic and restenotic vascular cells.

1997 • 171 citations

Decreased type II/type I TGF-beta receptor ratio in cells derived from human atherosclerotic lesions. Conversion from an antiproliferative to profibrotic response to TGF-beta1.

1995 • 171 citations

Smad2 and Smad4 gene mutations in hepatocellular carcinoma

1999 • 168 citations

TGF-β: A Critical Modulator of Immune Cell Function

1997 • 160 citations

Role of Transforming Growth Factor-β1 in Invasion and Metastasis in Gastric Carcinoma

1999 • 157 citations

Connective tissue growth factor: a novel regulator of mucosal repair and fibrosis in inflammatory bowel disease?

1998 • 156 citations

The expression of transforming growth factor-?1 is significantly correlated with the expression of vascular endothelial growth factor and poor prognosis of patients with advanced gastric carcinoma

1999 • 154 citations

Mutations of the DPC4/Smad4 gene in biliary tract carcinoma.

1998 • 148 citations

Elevated serum levels of transforming growth factor-?1 in patients with colorectal carcinoma

1999 • 140 citations

Transforming growth factor-beta 1 inhibits cyclin D1 expression in intestinal epithelial cells.

1995 • 134 citations

Transforming growth factor‐ß₁ in chronic hepatitis C

1997 • 133 citations

The Smad transcriptional corepressor TGIF recruits mSin3.

2001 • 132 citations

Alterations of the mucosal immune system in inflammatory bowel disease

1996 • 129 citations

Frequent loss of SMAD4/DPC4 protein in colorectal cancers

2002 • 126 citations

Reduced Expression of Transforming Growth Factor β Type I Receptor Contributes to the Malignancy of Human Colon Carcinoma Cells

1996 • 122 citations

A Gene for Familial Juvenile Polyposis Maps to Chromosome 18q21.1

1998 • 120 citations

Transforming growth factor‐β1 as a useful serologic marker of small hepatocellular carcinoma

2001 • 116 citations

Transforming growth factor beta type II receptor gene mutations in adenomas from hereditary nonpolyposis colorectal cancer

1997 • 107 citations

Attenuated ALK5 receptor expression in human pancreatic cancer: Correlation with resistance to growth inhibition

1996 • 107 citations

Role of growth factors and their receptors in gastric ulcer healing

2001 • 107 citations

Structural and Functional Characterization of the Transforming Growth Factor-β-induced Smad3/c-Jun Transcriptional Cooperativity

2000 • 105 citations

Mutations of the Transforming Growth Factor-β Type II Receptor Gene and Genomic Instability in Hereditary Nonpolyposis Colorectal Cancer

1995 • 103 citations

Production of and responsiveness to transforming growth factor-beta in normal and oncogene-transformed human mammary epithelial cells.

1989 • 102 citations

c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity

2001 • 100 citations

SMAD genes in juvenile polyposis

1999 • 96 citations

An elevated serum level of transforming growth factor-beta 1 (TGF-beta 1) significantly correlated with lymph node metastasis and poor prognosis in patients with gastric carcinoma.

2001 • 94 citations

Smad4 and transforming growth factor beta1 expression in patients with squamous cell carcinoma of the esophagus.

2002 • 91 citations

CELLS AND CYTOKINES IN MUCOSAL IMMUNITY AND INFLAMMATION

1992 • 89 citations

Expression of transforming growth factor beta type II receptor reduces tumorigenicity in human gastric cancer cells.

1997 • 83 citations

Genomic structure of the human Smad3 gene and its infrequent alterations in colorectal cancers

1998 • 82 citations

Cytokine mRNA Expression in Intestine from Normal and Inflammatory Bowel Disease Patients

1993 • 80 citations

The Expression of TGF-β Receptors in Human Atherosclerosis: Evidence for Acquired Resistance to Apoptosis due to Receptor Imbalance

1999 • 80 citations

A transforming growth factor beta type II receptor gene mutation common in sporadic cecum cancer with microsatellite instability.

1996 • 80 citations

Transforming growth factor-beta and cancer: a love-hate relationship?

1997 • 76 citations

Expression of and Response to Growth Regulatory Peptides by Two Human Pancreatic Carcinoma Cell Lines

1990 • 75 citations

Down-regulation of TGF-β receptors in human colorectal cancer: implications for cancer development

1999 • 75 citations

Evidence for a common cell of origin for primitive epithelial cells isolated from rat liver and pancreas

1991 • 68 citations

Screening SMAD1,SMAD2, SMAD3, andSMAD5 for germline mutations in juvenile polyposis syndrome

1999 • 67 citations

Protein-bound polysaccharide PSK inhibits tumor invasiveness by down-regulation of TGF-beta1 and MMPs.

2000 • 63 citations

Adhesion molecules and TGF-β1 are involved in the peritoneal dissemination of NUGC-4 human gastric cancer cells

1997 • 61 citations

Transforming growth factor-beta receptor type 2 mutations and microsatellite instability in sporadic colorectal adenomas and carcinomas.

1997 • 59 citations

Lessons from genetic models of inflammatory bowel disease.

1997 • 59 citations

Transforming growth factor‐β1 induces apoptosis in gastric cancer cells through a p53‐independent pathway

1996 • 58 citations

Quantitative analysis of transforming growth factor β1 messenger RNA in the liver of patients with chronic hepatitis C: Absence of correlation between high levels and severity of disease

1995 • 57 citations

Mutations of the transforming growth factor-β type II receptor gene are strongly related to sporadic proximal colon carcinomas with microsatellite instability

1996 • 56 citations

Mutation analysis of transforming growth factor beta type II receptor, Smad2, and Smad4 in hepatocellular carcinoma.

1999 • 54 citations

Preserved Smad4 expression in the transforming growth factor beta signaling pathway is a favorable prognostic factor in patients with advanced gastric cancer.

2001 • 53 citations

Mutation analysis of the Smad2 gene in human colon cancers using genomic DNA and intron primers

1998 • 36 citations

Overexpression of Transforming Growth Factor-β1 in Scirrhous Carcinoma of the Stomach Correlates with Decreased Survival

1998 • 34 citations

Overexpression of Smad2 and colocalization with TGF-beta1 in human pancreatic cancer.

1999 • 34 citations

True

2000 • 33 citations

Mutation analysis of transforming growth factor beta type II receptor, Smad2, Smad3 and Smad4 in esophageal squamous cell carcinoma.

2000 • 33 citations

Increased expression of transforming growth factor-beta1 during gastric ulcer healing in rats.

1997 • 30 citations

Gastrointestinal tumorigenesis in Smad4 (Dpc4) mutant mice.

2000 • 21 citations

No Mutations of the Smad2 Gene in Human Sporadic Gastric Carcinomas

1999 • 18 citations

Mutational analysis of the Smad6 and Smad7 genes in hepatocellular carcinoma

2001 • 18 citations

TGF-beta1 produced by gastric cancer cells affects mesothelial cell morphology in peritoneal dissemination.

1998 • 17 citations

Immunohistochemical localization of transforming growth factor-beta receptors I and II in inflammatory bowel disease.

1995 • 17 citations

Transforming growth factor-β (TGF-β1) inhibits pancreatic acinar cell growth

1992 • 17 citations

Genetic and epigenetic contributions to colorectal cancer

1999 • 14 citations

Expression of transforming growth factor β (TGF-β) may contribute, in part, to the variations in histogenesis and the prevalence of peritoneal dissemination in human gastric carcinoma

2000 • 12 citations

The progression of invasiveness regarding the role of transforming growth factor β receptor type II in gastric cancer

2000 • 11 citations

Immunohistochemical studies of transforming growth factor-beta and its receptors in the gastric mucosa of patients with refractory gastric ulcer.

1999 • 10 citations