Experimental Autoimmune Encephalomyelitis Induction in Genetically B Cell–deficient Mice

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene

1991 • 1,783 citations

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

Antigen-specific interaction between T and B cells

1985 • 1,396 citations

Immunological Aspects of Demyelinating Diseases

1992 • 1,021 citations

The T Lymphocyte in Experimental Allergic Encephalomyelitis

1990 • 1,005 citations

Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention

1988 • 940 citations

The rapid isolation of clonable antigen‐specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis

1981 • 917 citations

Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma.

1993 • 837 citations

Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ.

1990 • 670 citations

Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.

1994 • 630 citations

Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease.

1994 • 599 citations

B Cells Turn Off Virgin But Not Memory T Cells

1992 • 578 citations

Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy

1988 • 555 citations

Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions.

1995 • 473 citations

Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens.

1992 • 435 citations

Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo.

1995 • 410 citations

Immunological Aspects of Experimental Allergic Encephalomyelitis and Multiple Sclerosis

1995 • 381 citations

Targeted disruption of µ chain membrane exon causes loss of heavy-chain allelic exclusion

1992 • 376 citations

Resting and sensitized T lymphocytes exhibit distinct stimulatory (antigen-presenting cell) requirements for growth and lymphokine release.

1984 • 346 citations

B lymphocytes can be competent antigen-presenting cells for priming CD4+ T cells to protein antigens in vivo.

1995 • 303 citations

Successful T cell priming in B cell-deficient mice.

1995 • 284 citations

Regulation of T‐Cell Activation; Differences among T‐Cell Subsets

1989 • 271 citations

Induction of autoreactive B cells allows priming of autoreactive T cells.

1991 • 253 citations

The B cell is the initiating antigen-presenting cell in peripheral lymph nodes.

1987 • 240 citations

Antigen-pulsed dendritic cells can efficiently induce an antibody response in vivo.

1992 • 215 citations

B lymphocytes in vivo fail to prime naive T cells but can stimulate antigen-experienced T lymphocytes.

1993 • 210 citations

The role of antigen-presenting B cells in T cell priming in vivo. Studies of B cell-deficient mice.

1988 • 199 citations

The involvement of T cell receptor peptide-specific regulatory CD4+ T cells in recovery from antigen-induced autoimmune disease.

1993 • 197 citations

Can B cells turn on virgin T cells?

1988 • 192 citations

Control of the Immune Response at the Level of Antigen-Presenting Cells: A Comparison of the Function of Dendritic Cells and B Lymphocytes

1989 • 163 citations

Major histocompatibility complex-linked control of the murine immune response to myelin basic protein.

1985 • 154 citations

Cutaneous leishmaniasis in anti-IgM-treated mice: enhanced resistance due to functional depletion of a B cell-dependent T cell involved in the suppressor pathway.

1984 • 153 citations

Prevention of experimental allergic encephalomyelitis in rats by targeting autoantigen to B cells: evidence that the protective mechanism depends on changes in the cytokine response and migratory properties of the autoantigen-specific T cells.

1995 • 150 citations

Antigen presentation by splenic B cells: resting B cells are ineffective, whereas activated B cells are effective accessory cells for T cell responses.

1985 • 145 citations

Recently activated naive CD4 T cells can help resting B cells, and can produce sufficient autocrine IL-4 to drive differentiation to secretion of T helper 2-type cytokines.

1995 • 144 citations

A quantitative analysis of antigen-presenting cell function: activated B cells stimulate naive CD4 T cells but are inferior to dendritic cells in providing costimulation.

1994 • 133 citations

Microbial induction of co-stimulatory activity for CD4 T-cell growth

1991 • 130 citations

CD4+ T cell activation and tolerance induction in B cell knockout mice.

1996 • 103 citations

Defective induction of antigen‐reactive proliferating T cells in B cell‐deprived mice

1981 • 99 citations

Immunoglobulin-deficient rats fail to develop experimental allergic encephalomyelitis

1983 • 99 citations

Dendritic cells but not B cells present antigenic complexes to class II-restricted T cells after administration of protein in adjuvant.

1996 • 99 citations

Distinct features of dendritic cells and anti-Ig activated B cells as stimulators of the primary mixed leukocyte reaction.

1989 • 96 citations

In vivo activation of naive T cells by antigen-presenting B cells.

1994 • 95 citations

T cell development in B cell-deficient mice. IV. The role of B cells as antigen-presenting cells in vivo.

1986 • 88 citations

Synergy between encephalitogenic T cells and myelin basic protein-specific antibodies in the induction of experimental autoimmune encephalomyelitis

1992 • 86 citations

Relationships among antigen presentation, cytokines, immune deviation, and autoimmune disease.

1995 • 75 citations

Antigen-specific activation, tolerization, and reactivation of the interleukin 4 pathway in vivo.

1994 • 74 citations

Altered response of CD4⁺ T cell subsets to Plasmodium chabaudi chabaudi in B cell-deficient mice

1993 • 62 citations

Regulation of antigen-presentation-I. IFN-gamma induces antigen-presenting properties on B cells.

1988 • 49 citations

Immunoglobulin deficient rats as donors and recipients of effector cells of allergic encephalomyelitis

1986 • 45 citations

Strong priming of T cells adoptively transferred into scid mice.

1991 • 42 citations

T cell development in B cell-deficient mice. II. Serological characterization of suppressor T cell factors (TsF1) produced in normal mice and in mice treated chronically with rabbit anti-mouse IgM antibodies.

1985 • 37 citations