Lymphocyte proliferation in immune-mediated diseases

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

2001 • 2,503 citations

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

2006 • 1,702 citations

Adoptive Cell Transfer Therapy Following Non-Myeloablative but Lymphodepleting Chemotherapy for the Treatment of Patients With Refractory Metastatic Melanoma

2005 • 1,613 citations

CD69 acts downstream of interferon-α/β to inhibit S1P1 and lymphocyte egress from lymphoid organs

2006 • 1,092 citations

Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells

2005 • 1,000 citations

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

2008 • 999 citations

Neonatal adaptive immunity comes of age

2004 • 966 citations

Cutting Edge: Cure of Colitis by CD4+CD25+ Regulatory T Cells

2003 • 933 citations

Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease

2007 • 887 citations

Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction

2008 • 705 citations

Homeostatic Expansion of T Cells during Immune Insufficiency Generates Autoimmunity

2004 • 682 citations

Naive T Cells Transiently Acquire a Memory-like Phenotype during Homeostasis-Driven Proliferation

2000 • 644 citations

Maintaining the norm: T-cell homeostasis

2002 • 608 citations

Cytokine Requirements for Acute and Basal Homeostatic Proliferation of Naive and Memory CD8+ T Cells

2002 • 588 citations

Homeostasis-Stimulated Proliferation Drives Naive T Cells to Differentiate Directly into Memory T Cells

2000 • 527 citations

CD8⁺ T‐cell memory in tumor immunology and immunotherapy

2006 • 472 citations

CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells.

1993 • 471 citations

Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells

2003 • 454 citations

T cell homeostasis in patients with rheumatoid arthritis

2000 • 453 citations

Melanocyte Destruction after Antigen-Specific Immunotherapy of Melanoma

2000 • 423 citations

Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells

2005 • 378 citations

HIV and autoimmunity

2002 • 369 citations

Cutting Edge: Depletion of CD4+CD25+ Regulatory T Cells Is Necessary, But Not Sufficient, for Induction of Organ-Specific Autoimmune Disease

2002 • 332 citations

T cell immune reconstitution following lymphodepletion

2007 • 312 citations

T cell homeostatic proliferation elicits effective antitumor autoimmunity

2002 • 312 citations

Neonates Support Lymphopenia-Induced Proliferation

2003 • 291 citations

IL-21 drives secondary autoimmunity in patients with multiple sclerosis, following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H)

2009 • 287 citations

T cell homeostatic proliferation elicits effective antitumor autoimmunity

2002 • 262 citations

Cutting Edge: Recent Immune Status Determines the Source of Antigens That Drive Homeostatic T Cell Expansion

2005 • 243 citations

No Alterations in the Frequency of FOXP3+ Regulatory T-Cells in Type 1 Diabetes

2007 • 242 citations

Interleukin-15 rescues tolerant CD8+ T cells for use in adoptive immunotherapy of established tumors

2006 • 234 citations

Viral infections as potential triggers of type 1 diabetes

2006 • 227 citations

The generation of protective memory-like CD8+ T cells during homeostatic proliferation requires CD4+ T cells

2006 • 209 citations

IL-21 signaling is critical for the development of type I diabetes in the NOD mouse

2008 • 205 citations

Spontaneous and Homeostatic Proliferation of CD4 T Cells Are Regulated by Different Mechanisms

2005 • 201 citations

Hematopoietic stem cells promote the expansion and function of adoptively transferred antitumor CD8+ T cells

2007 • 201 citations

Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells

2008 • 192 citations

Cyclophosphamide-Induced Type-1 Diabetes in the NOD Mouse Is Associated with a Reduction of CD4+CD25+Foxp3+ Regulatory T Cells

2006 • 179 citations

Autoimmunity during lymphopenia: A two-hit model

2006 • 176 citations

Mechanisms of T regulatory cell function

2008 • 176 citations

Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7–dependent homeostatic proliferation of CD4+ T cells

2006 • 169 citations

Interleukin-21 Is Required for the Development of Type 1 Diabetes in NOD Mice

2009 • 164 citations

IL-6–dependent spontaneous proliferation is required for the induction of colitogenic IL-17–producing CD8+ T cells

2008 • 162 citations

Spontaneous proliferation, a response of naïve CD4 T cells determined by the diversity of the memory cell repertoire

2004 • 154 citations

Interleukin-2 Administration Alters the CD4+FOXP3+ T-Cell Pool and Tumor Trafficking in Patients with Ovarian Carcinoma

2007 • 151 citations

Control of Neonatal Tolerance to Tissue Antigens by Peripheral T Cell Trafficking

1998 • 141 citations

Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity

2008 • 131 citations

T cell homeostasis in tolerance and immunity

2005 • 128 citations

A causal link between lymphopenia and autoimmunity

2004 • 128 citations

T cell homeostasis: Keeping useful T cells alive and live T cells useful

2005 • 124 citations

CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity

2008 • 123 citations

The new paradigm of T-cell homeostatic proliferation-induced autoimmunity

2004 • 122 citations

Cutting Edge: Broad Expression of the FoxP3 Locus in Epithelial Cells: A Caution against Early Interpretation of Fatal Inflammatory Diseases following In Vivo Depletion of FoxP3-Expressing Cells

2008 • 118 citations

A hypomorphic R229Q Rag2 mouse mutant recapitulates human Omenn syndrome

2007 • 111 citations

Lymphopenic mice reconstituted with limited repertoire T cells develop severe, multiorgan, Th2-associated inflammatory disease

2007 • 105 citations

Homeostatic Proliferation of Lymphocytes Results in Augmented Memory-Like Function and Accelerated Allograft Rejection

2008 • 102 citations

Suppression of CD4+ T Lymphocyte Effector Functions by CD4+CD25+ Cells In Vivo

2004 • 99 citations

Control of homeostatic proliferation by regulatory T cells

2005 • 98 citations

The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis

2005 • 95 citations

Melan-A–specific Cytotoxic T Cells Are Associated with Tumor Regression and Autoimmunity Following Treatment with Anti-CTLA-4

2009 • 93 citations

Homeostatic Proliferation Plus Regulatory T-Cell Depletion Promotes Potent Rejection of B16 Melanoma

2008 • 90 citations

Homeostatic Proliferation as an Isolated Variable Reverses CD8+ T Cell Anergy and Promotes Tumor Rejection

2006 • 86 citations

CD24: a genetic checkpoint in T cell homeostasis and autoimmune diseases

2007 • 83 citations

Rheumatologic complications of HIV infection

2006 • 77 citations

Lack of Foxp3 function and expression in the thymic epithelium

2007 • 76 citations

Homeostatically proliferating CD4+ T cells are involved in the pathogenesis of an Omenn syndrome murine model

2007 • 73 citations

Regulatory CD4+CD25+Foxp3+ T Cells Selectively Inhibit the Spontaneous Form of Lymphopenia-Induced Proliferation of Naive T Cells

2008 • 70 citations

Lymphopenia and autoimmune diseases.

2004 • 69 citations

Rheumatologic and autoimmune manifestations of primary immunodeficiency disorders

2008 • 68 citations

Regulatory potential and control ofFoxp3expression in newborn CD4⁺T cells

2004 • 68 citations

Breakdown of T cell tolerance and autoimmunity in primary immunodeficiency—lessons learned from monogenic disorders in mice and men

2008 • 61 citations

Inability to Mediate Prolonged Reduction of Regulatory T Cells After Transfer of Autologous CD25-depleted PBMC and Interleukin-2 After Lymphodepleting Chemotherapy

2007 • 61 citations

Memory-like CD8⁺and CD4⁺T cells cooperate to break peripheral tolerance under lymphopenic conditions

2008 • 58 citations

CD25+CD4+ Regulatory T Cells and Memory T Cells Prevent Lymphopenia-Induced Proliferation of Naive T Cells in Transient States of Lymphopenia

2006 • 52 citations

A Major Role for Memory CD4 T Cells in the Control of Lymphopenia-Induced Proliferation of Naive CD4 T Cells

2005 • 48 citations

Thelymphopenia mutation of the BB rat causes inappropriate apoptosis of mature thymocytes

1999 • 48 citations

IL-21 Limits Peripheral Lymphocyte Numbers through T Cell Homeostatic Mechanisms

2008 • 48 citations

Autoantibodies against galectin-8: their specificity, association with lymphopenia in systemic lupus erythematosus and detection in rheumatoid arthritis and acute inflammation

2009 • 44 citations

Autoimmunity in Severe Combined Immunodeficiency (SCID): Lessons from Patients and Experimental Models

2008 • 42 citations

Lymphopenia in occupational pulmonary silicosis with or without autoimmune disease

2001 • 40 citations

Prevention of spontaneous arthritis by inhibiting homeostatic expansion of autoreactive CD4+ T cells in the K/BxN mouse model

2006 • 38 citations

IL-21 Induces Apoptosis of Antigen-Specific CD8+ T Lymphocytes

2007 • 33 citations

Physiologic regulation of central and peripheral T cell tolerance: lessons for therapeutic applications

2006 • 32 citations

Homeostatic Proliferation in the Mice with Germline FoxP3 Mutation and its Contribution to Fatal Autoimmunity

2008 • 30 citations

Tumor immunity via homeostatic T cell proliferation: mechanistic aspects and clinical perspectives

2005 • 27 citations

Control of peripheral T-lymphocyte tolerance in neonates and adults

2005 • 22 citations

Defective positive selection results in T cell lymphopenia and increased autoimmune diabetes in ADAP‐deficient BDC2.5‐C57BL/6 mice

2008 • 14 citations

Lymphopenia‐driven CD8⁺ T cells are resistant to antigen‐induced tolerance in NOD.scid mice

2006 • 9 citations

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