Role and mechanisms of CD4+CD25+ regulatory T cells in the induction and maintenance of transplantation tolerance

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

2005 • 4,573 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

2002 • 1,745 citations

Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β

2001 • 1,609 citations

Immunologic tolerance maintained by CD25⁺ CD4⁺ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

2001 • 1,515 citations

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

1996 • 1,457 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 1,434 citations

Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation.

1996 • 1,335 citations

Regulatory T cells in transplantation tolerance

2003 • 1,323 citations

Suppressor Effector Function of CD4+CD25+ Immunoregulatory T Cells Is Antigen Nonspecific

2000 • 1,282 citations

Thymus and Autoimmunity: Production of CD25+CD4+ Naturally Anergic and Suppressive T Cells as a Key Function of the Thymus in Maintaining Immunologic Self-Tolerance

1999 • 1,223 citations

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

1993 • 1,219 citations

Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFI

1990 • 1,155 citations

Donor-type CD4+CD25+ Regulatory T Cells Suppress Lethal Acute Graft-Versus-Host Disease after Allogeneic Bone Marrow Transplantation

2002 • 1,117 citations

Antigen-Specific T Cell Sensitization Is Impaired in IL-17-Deficient Mice, Causing Suppression of Allergic Cellular and Humoral Responses

2002 • 1,063 citations

Unique Chemotactic Response Profile and Specific Expression of Chemokine Receptors Ccr4 and Ccr8 by Cd4+Cd25+ Regulatory T Cells

2001 • 888 citations

Type 1 T regulatory cells

2001 • 829 citations

Tolerization of dendritic cells by TS cells: the crucial role of inhibitory receptors ILT3 and ILT4

2002 • 800 citations

IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo

2001 • 799 citations

CD25+CD4+ Regulatory T Cells Prevent Graft Rejection: CTLA-4- and IL-10-Dependent Immunoregulation of Alloresponses

2002 • 766 citations

Cutting Edge: Control of CD8+ T Cell Activation by CD4+CD25+ Immunoregulatory Cells

2001 • 743 citations

IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo

2006 • 712 citations

Regulatory T Cells Induced by 1α,25-Dihydroxyvitamin D3 and Mycophenolate Mofetil Treatment Mediate Transplantation Tolerance

2001 • 627 citations

Infectious Tolerance

2002 • 614 citations

Cd4+Cd25+ Immune Regulatory Cells Are Required for Induction of Tolerance to Alloantigen via Costimulatory Blockade

2001 • 580 citations

Identification of Regulatory T Cells in Tolerated Allografts

2002 • 577 citations

A Role for TGF-β in the Generation and Expansion of CD4+CD25+ Regulatory T Cells from Human Peripheral Blood

2001 • 540 citations

Recipient-type specific CD4+CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia

2003 • 501 citations

B cells and professional APCs recruit regulatory T cells via CCL4

2001 • 496 citations

Human CD4+CD25+ Regulatory, Contact-dependent T Cells Induce Interleukin 10–producing, Contact-independent Type 1-like Regulatory T Cells

2002 • 484 citations

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells

2012 • 462 citations

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+regulatory T cells

2005 • 451 citations

Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression

2000 • 448 citations

Triggering of OX40 (CD134) on CD4+CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR

2005 • 406 citations

Phenotype, Localization, and Mechanism of Suppression of CD4+CD25+ Human Thymocytes

2002 • 384 citations

Both CD4+CD25+ and CD4+CD25− Regulatory Cells Mediate Dominant Transplantation Tolerance

2002 • 372 citations

The role of "indirect" recognition in initiating rejection of skin grafts from major histocompatibility complex class II-deficient mice.

1993 • 325 citations

Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. III. Further characterization of the CD4+ suppressor cell and its mechanisms of action.

1990 • 302 citations

WEANING OF IMMUNOSUPPRESSION IN LIVING DONOR LIVER TRANSPLANT RECIPIENTS1

2001 • 295 citations

TGF-β Requires CTLA-4 Early after T Cell Activation to Induce FoxP3 and Generate Adaptive CD4+CD25+ Regulatory Cells

2006 • 291 citations

Requirement for natural killer T (NKT) cells in the induction of allograft tolerance

2001 • 270 citations

Inhibition of Human CD4+CD25+high Regulatory T Cell Function

2002 • 266 citations

Favorably Tipping the Balance between Cytopathic and Regulatory T Cells to Create Transplantation Tolerance

2003 • 255 citations

Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host disease

2005 • 243 citations

Human CD4+ CD25+ regulatory T cells suppress NKT cell functions.

2003 • 225 citations

Effect of One-HLA-DR-Antigen–Matched and Completely HLA-DR–Mismatched Blood Transfusions on Survival of Heart and Kidney Allografts

1989 • 224 citations

T Cell Death and Transplantation Tolerance

2001 • 218 citations

CD4+CD25+ regulatory T cells suppress allograft rejection mediated by memory CD8+ T cells via a CD30-dependent mechanism

2004 • 210 citations

TGF-β: the missing link in CD4+CD25+ regulatory T cell-mediated immunosuppression

2003 • 207 citations

Agonist Anti-GITR Antibody Enhances Vaccine-Induced CD8+ T-Cell Responses and Tumor Immunity

2006 • 201 citations

Regulatory T Cells Overexpress a Subset of Th2 Gene Transcripts

2002 • 180 citations

Tracking the Immunoregulatory Mechanisms Active During Allograft Tolerance

2002 • 180 citations

The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockade

2003 • 180 citations

Cutting Edge: CD4+CD25+ Alloantigen-Specific Immunoregulatory Cells That Can Prevent CD8+ T Cell-Mediated Graft Rejection: Implications for Anti-CD154 Immunotherapy

2002 • 177 citations

Role of GITR in activation response of T lymphocytes

2002 • 169 citations

Dominant transplantation tolerance impairs CD8+ T cell function but not expansion

2002 • 161 citations

AMPLIFICATION OF NATURAL REGULATORY IMMUNE MECHANISMS FOR TRANSPLANTATION TOLERANCE1

1996 • 161 citations

Low circulating regulatory T-cell levels after acute rejection in liver transplantation

2006 • 141 citations

Cutting Edge: Recipient MHC Class II Expression Is Required to Achieve Long-Term Survival of Murine Cardiac Allografts After Costimulatory Blockade

2001 • 125 citations

Critical, but Conditional, Role of OX40 in Memory T Cell-Mediated Rejection

2006 • 122 citations

GITR Activation Induces an Opposite Effect on Alloreactive CD4+ and CD8+ T Cells in Graft-Versus-Host Disease

2004 • 103 citations

OX40-OX40 Ligand Interaction through T Cell-T Cell Contact Contributes to CD4 T Cell Longevity

2006 • 100 citations

Human CD4⁺CD25⁺ regulatory cells have marked and sustained effects on CD8⁺ T cell activation

2003 • 91 citations

Regulatory T Cells in the Control of Transplantation Tolerance and Autoimmunity

2003 • 90 citations

IL-10-dependent infectious tolerance after the treatment of experimental allergic encephalomyelitis with redirected CD4 ⁺ CD25 ⁺ T lymphocytes

2005 • 88 citations

A Signal through OX40 (CD134) Allows Anergic, Autoreactive T Cells to Acquire Effector Cell Functions

2004 • 87 citations

Transfer of regulatory T cells generated ex vivo modifies graft rejection through induction of tolerogenic CD4+CD25+ cells in the recipient

2006 • 79 citations

Human CD4+CD25+ regulatory T cells and infectious tolerance.

2004 • 69 citations

Interleukin-17 stimulates the expression of IκBα mRNA and the secretion of IL-6 and IL-8 in glioblastoma cell lines

1999 • 65 citations

CD8+ T cells produce IL-2, which is required for CD4+CD25+ T cell regulation of effector CD8+ T cell development for contact hypersensitivity responses

2005 • 61 citations

The Role of the IL-2 Pathway in Costimulation Blockade-Resistant Rejection of Allografts

2002 • 52 citations

CD25+ Immunoregulatory CD4 T Cells Mediate Acquired Central Transplantation Tolerance

2003 • 46 citations

Signaling Through the Murine T Cell Receptor Induces IL-17 Production in the Absence of Costimulation, IL-23 or Dendritic Cells

2005 • 42 citations

A novel mechanism of regulatory T cell-mediated down-regulation of autoimmunity

2006 • 34 citations

Signal transduction in CD4+CD25+ regulatory T cells: CD25 and IL-2

2006 • 30 citations

Specificity of regulatory CD4⁺CD25⁺ T cells for self‐T cell receptor determinants

2004 • 29 citations

Biochemical features of anergic T cells

1998 • 19 citations

Chemokines involved in protection from colitis by CD4+CD25+ regulatory T cells

2006 • 18 citations

CTLA-4 Engagement and Regulatory CD4+CD25+ T Cells Independently Control CD8+-Mediated Responses under Costimulation Blockade

2006 • 17 citations

Transplantation tolerance: mechanisms and strategies?

2000 • 15 citations

A short course of mycophenolate immunosuppression inhibits rejection, but not tolerance, of rat liver allografts in association with inhibition of interleukin-4 and alloantibody responses

2003 • 13 citations

Long-term acceptance of porcine pulmonary allografts without chronic rejection

2005 • 12 citations

[The influence of mycophenolate mofetil upon the maturation and allostimulatory activity of cultured dendritic cell progenitors and the effects of tolerance induction in allograft recipients].

2005 • 9 citations

Circumventing tolerance at the T cell or the antigen‐presenting cell surface: Antibodies that ligate CD40 and OX40 have different effects

2006 • 8 citations

Tolerance-inducing strategies in transplantation surgery?current status and perspectives

2004 • 5 citations