γδ T Cells Play an Essential Role in Several Forms of Tolerance

Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye.

1948 • 1,042 citations

Identification of a putative second T-cell receptor

1986 • 980 citations

Regulation of Cutaneous Malignancy by γδ T Cells

2001 • 945 citations

Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens

1994 • 895 citations

Gamma/Delta Cells

1993 • 819 citations

Stimulation of Human γδ T Cells by Nonpeptidic Mycobacterial Ligands

1994 • 685 citations

Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivo

1995 • 672 citations

Specificity and function of T cells bearing γδ receptors

1988 • 570 citations

Evidence for function of Ia molecules on gut epithelial cells in man.

1987 • 521 citations

A third type of murine T-cell receptor gene

1984 • 491 citations

Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients.

1996 • 487 citations

Immunoregulation in the tissues by γδ T cells

2003 • 412 citations

Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through in vivo ligation of CD40

1999 • 409 citations

The nature of major histocompatibility complex recognition by γδ T cells

1994 • 407 citations

Regulation of IgE Responses to Inhaled Antigen in Mice by Antigen-Specific γδ T Cells

1994 • 406 citations

A protective role of gamma/delta T cells in primary infection with Listeria monocytogenes in mice.

1992 • 393 citations

Adaptive Immune Response of Vγ2Vδ2 ⁺ T Cells During Mycobacterial Infections

2002 • 368 citations

Aerosol Insulin Induces Regulatory CD8 γδ T Cells That Prevent Murine Insulin-dependent Diabetes

1996 • 315 citations

Differentiation of Effector/Memory Vδ2 T Cells and Migratory Routes in Lymph Nodes or Inflammatory Sites

2003 • 305 citations

V gamma 2V delta 2 TCR-dependent recognition of non-peptide antigens and Daudi cells analyzed by TCR gene transfer.

1995 • 276 citations

T lymphocytes from healthy individuals with specificity to self-epitopes shared by the mycobacterial and human 65-kilodalton heat shock protein.

1989 • 237 citations

Qa-1 restricted recognition of foreign antigen by a γδ T-cell hybridoma

1989 • 233 citations

Gamma delta T lymphocytes regulate the induction and maintenance of oral tolerance.

1997 • 227 citations

Gamma delta T cells contribute to immunity against the liver stages of malaria in alpha beta T-cell-deficient mice.

1994 • 207 citations

Immune protection and control of inflammatory tissue necrosis by gamma delta T cells.

1994 • 189 citations

Resident Skin-specific γδ T Cells Provide Local, Nonredundant Regulation of Cutaneous Inflammation

2002 • 188 citations

Beta 2-integrin LFA-1 signaling through phospholipase C-gamma 1 activation.

1993 • 185 citations

Limited diversity of the rearranged T-cell γ gene

1985 • 185 citations

Cytotoxic differentiation of mouse gut thymodependent and independent intraepithelial T lymphocytes is induced locally. Correlation between functional assays, presence of perforin and granzyme transcripts, and cytoplasmic granules.

1991 • 183 citations

Subretinal space and vitreous cavity as immunologically privileged sites for retinal allografts.

1993 • 178 citations

Recognition of a self major histocompatibility complex TL region product by gamma delta T-cell receptors.

1989 • 168 citations

Cutting edge: protective response to pulmonary injury requires gamma delta T lymphocytes.

1999 • 163 citations

Propagation and regulation of systemic autoimmunity by gammadelta T cells.

1996 • 155 citations

Impaired cell-mediated immunity in mice bearing healthy orthotopic corneal allografts.

1993 • 155 citations

Mouse CD1-Autoreactive T Cells Have Diverse Patterns of Reactivity to CD1+ Targets

1998 • 152 citations

Control of Syngeneic Tumor Growth by Activation of CD8+ T Cells: Efficacy Is Limited by Migration Away from the Site and Induction of Nonresponsiveness

1999 • 146 citations

Induction of murine peritoneal gamma/delta T cells and their role in resistance to bacterial infection.

1993 • 144 citations

Depletion of IL-10- and TGF-beta-producing regulatory gamma delta T cells by administering a daunomycin-conjugated specific monoclonal antibody in early tumor lesions augments the activity of CTLs and NK cells.

1999 • 144 citations

Vγ1+ T Cells Suppress and Vγ4+ T Cells Promote Susceptibility to Coxsackievirus B3-Induced Myocarditis in Mice

2000 • 139 citations

Role of gamma delta T cells in murine collagen-induced arthritis.

1993 • 126 citations

Characterization of gamma delta T lymphocytes at the maternal-fetal interface.

1992 • 122 citations

Gamma delta T cells can recognize nonclassical MHC in the absence of conventional antigenic peptides.

1994 • 122 citations

Anti-γδ T cell antibody blocks the induction and maintenance of oral tolerance to ovalbumin in mice

1995 • 118 citations

Bacterial infection of the testis leading to autoaggressive immunity triggers apparently opposed responses of alpha beta and gamma delta T cells.

1995 • 112 citations

γδ T Cells Are Needed for Ocular Immune Privilege and Corneal Graft Survival

2001 • 109 citations

In vivo cytokine production in murine listeriosis. Evidence for immunoregulation by gamma delta+ T cells.

1996 • 106 citations

Structure and Function of Intestinal Mucosal Epithelium

1994 • 105 citations

Primary gamma delta cell clones can be defined phenotypically and functionally as Th1/Th2 cells and illustrate the association of CD4 with Th2 differentiation.

1998 • 105 citations

A role for gamma delta + T cells during experimental infection of mice with Leishmania major.

1993 • 104 citations

Oral antigen inhibits priming of CD8+ CTL, CD4+ T cells, and antibody responses while activating CD8+ suppressor T cells.

1996 • 101 citations

Heat shock proteins can regulate expression of the Tla region-encoded class Ib molecule Qa-1.

1991 • 101 citations

Distinctive humoral immune responses following anterior chamber and intravenous administration of soluble antigen. Evidence for active suppression of IgG2-secreting B lymphocytes.

1990 • 97 citations

Human γδT Cells that Inhibit the In Vitro Growth of the Asexual Blood Stages of the Plasmodium falciparum Parasite Express Cytolytic and Proinflammatory Molecules

1999 • 88 citations

Oral Tolerance and Regulation of Immunity to Dietary Antigens

1994 • 86 citations

Regulatory role of gamma delta T cells in uterine intraepithelial lymphocytes in maternal antifetal immune response.

1995 • 84 citations

Prolonged survival of thymoma-bearing mice after vaccination with a soluble protein antigen entrapped in liposomes: a model study.

1992 • 78 citations

Orally induced, peptide‐specific γ/δ TCR⁺ cells suppress experimental autoimmune uveitis

1996 • 72 citations

γδ T Cells in Host Defense and Epithelial Cell Biology

1998 • 67 citations

Resistance to cutaneous graft-vs.-host disease is not induced in T cell receptor delta gene-mutant mice.

1996 • 64 citations

Antigens recognized by λδ T cells

1994 • 64 citations

Antigen processing by isolated rat intestinal villus enterocytes.

1989 • 64 citations

T cell receptor-triggered activation of intraepithelial lymphocytes in vitro

1993 • 57 citations

Conservation of Nonpeptide Antigen Recognition by Rhesus Monkey Vγ2Vδ2 T Cells

2003 • 57 citations

An age‐related γδ T cell suppressor activity correlates with the outcome of autoimmunity in experimental Trypanosoma cruzi infection

1993 • 53 citations

Antigen Handling by the Epithelium and Lamina Propria Macrophages

1991 • 52 citations

Regulation of T-cell sensitization at epithelial surfaces in the respiratory tract: suppression of IgE responses to inhaled antigens by CD3+ Tcr alpha-/beta- lymphocytes (putative gamma/delta T cells).

1991 • 52 citations

γδ T‐cell clones from intestinal intraepithelial lymphocytes inhibit development of CTL responses ex vivo

2004 • 52 citations

Basic Aspects of Intraepithelial Lymphocyte Immunobiology

1994 • 51 citations

Multiple Sclerosis: Limited Diversity of the Vδ2‐Jδ3 T‐Cell Receptor in Chronic Active Lesions

1995 • 48 citations

Down-regulation of tumoricidal NK and NK T cell activities by MHC Kb molecules expressed on Th2-type gammadelta T and alphabeta T cells coinfiltrating in early B16 melanoma lesions.

1998 • 48 citations

Novel antigenic determinants of the T200 glycoprotein expressed preferentially by activated cytotoxic T lymphocytes.

1985 • 47 citations

γδ T cells are critical for the induction of anterior chamber‐associated immune deviation

2001 • 44 citations

In vitro and in vivo activation of murine gamma/delta T cells induces the expression of IgA, IgM, and IgG Fc receptors.

1992 • 43 citations

Issues concerning the nature of antigen recognition by αβ and γδ T-cell receptors

1995 • 40 citations

Direct presentation of non-peptide prenyl pyrophosphate antigens to human γδ T cells

1996 • 38 citations

Innate and adaptive immunity to tumors: IL-12 is required for optimal responses

2000 • 37 citations

Gammadelta T cells in anterior chamber-induced tolerance in CD8(+) CTL responses.

2002 • 34 citations

Inhibition of tumor rejection by γδ T cells and IL-10

2003 • 32 citations

Suppression of cytotoxic T lymphocyte activity by ?/? T cells in tumor-bearing mice

1995 • 30 citations

Response of Murine γδ T Cells to the Synthetic Polypeptide Poly-Glu50Tyr50 1

2000 • 25 citations

Expansion of the γδ T cell subset in vivo during bloodstage malaria in B cell-deficient mice

1996 • 23 citations

Diversity and Function of Antigen-Presenting Cells in Mucosal Tissues

1994 • 20 citations

Role of γδ T cells in tumor immunity and their control by NK receptors

1999 • 20 citations

γδ T Cells in Anterior Chamber-Induced Tolerance in CD8+ CTL Responses

2002 • 19 citations

CD75s is a marker of murine CD8+ suppressor T cells

2003 • 18 citations

Insulin-specific tolerance induction. I. Abrogation of helper T cell activity is controlled by H-2-linked Ir genes.

1984 • 10 citations

Tumor formation suppressed in γδT knock-out mice

2000 • 7 citations

Characterization of the epitope recognized by a mAb that reacts differentially with murine suppressor T cells

1995 • 7 citations

Production of a soluble γδ T-cell receptor to identify ligands for the murine intestinal intraepithelial γδ T cell population

2003 • 6 citations

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