Fruit Polyphenols and Their Effects on Neuronal Signaling and Behavior in Senescence

The Cholinergic Hypothesis of Geriatric Memory Dysfunction

1982 • 5,422 citations

Microglia: a sensor for pathological events in the CNS

1996 • 4,309 citations

Cellular defenses against damage from reactive oxygen species

1994 • 2,393 citations

An application of prefrontal cortex function theory to cognitive aging.

1996 • 1,933 citations

Role of Free Radicals in the Neurodegenerative Diseases

2001 • 1,490 citations

Oxidative Stress in Neurodegenerative Diseases

1996 • 1,336 citations

The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases

1995 • 1,290 citations

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

1991 • 1,290 citations

REGULATION OF GENE EXPRESSION BY REACTIVE OXYGEN

1999 • 1,102 citations

Dietary Intake of Antioxidants and Risk of Alzheimer Disease

2002 • 1,068 citations

Reversals of Age-Related Declines in Neuronal Signal Transduction, Cognitive, and Motor Behavioral Deficits with Blueberry, Spinach, or Strawberry Dietary Supplementation

1999 • 983 citations

A Requirement for the Mitogen-activated Protein Kinase Cascade in Hippocampal Long Term Potentiation

1997 • 866 citations

Oxygen radicals and the nervous system

1985 • 822 citations

Oxidative stress in brain agingImplications for therapeutics of neurodegenerative diseases

2002 • 810 citations

Oxidative Stress, Antioxidant Defenses, and Damage Removal, Repair, and Replacement Systems

2000 • 762 citations

Parallel information processing in the water maze: Evidence for independent memory systems involving dorsal striatum and hippocampus

1994 • 732 citations

Flavonoids in Health and Disease

2003 • 710 citations

Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease

1995 • 641 citations

Oxidative stress and nitration in neurodegeneration: Cause, effect, or association?

2003 • 634 citations

Oxidative stress and nitration in neurodegeneration: Cause, effect, or association?

2003 • 626 citations

Antioxidant and antiinflammatory activities of anthocyanins and their aglycon, cyanidin, from tart cherries

1999 • 621 citations

The role of oxidative damage and stress in aging

2004 • 611 citations

Inflammation and neurodegeneration in Parkinson's disease

2004 • 603 citations

Activation of p42 Mitogen-activated Protein Kinase in Hippocampal Long Term Potentiation

1996 • 575 citations

Nitric oxide and oxygen radicals: a question of balance

1995 • 568 citations

Increased Peroxidation and Reduced Antioxidant Enzyme Activity in Alzheimer's Disease

1998 • 497 citations

Antioxidant and Antiinflammatory Activities of Anthocyanins and Their Aglycon, Cyanidin, from Tart Cherries

1999 • 484 citations

Cyclooxygenase inhibitory and antioxidant cyanidin glycosides in cherries and berries

2001 • 482 citations

Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: implications for the pathogenesis of neurodegenerative diseases.

2003 • 453 citations

Long-Term Dietary Strawberry, Spinach, or Vitamin E Supplementation Retards the Onset of Age-Related Neuronal Signal-Transduction and Cognitive Behavioral Deficits

1998 • 434 citations

Cardiovascular Disease, Interleukin-6, and Risk of Mortality in Older Women

2001 • 431 citations

Memory Consolidation for Contextual and Auditory Fear Conditioning Is Dependent on Protein Synthesis, PKA, and MAP Kinase

1999 • 403 citations

Increased levels of lipid hydroperoxides in the parkinsonian substantia nigra: An HPLC and ESR study

1994 • 399 citations

An introduction to the free radical hypothesis in Parkinson's disease

1992 • 385 citations

Blueberry Supplementation Enhances Signaling and Prevents Behavioral Deficits in an Alzheimer Disease Model

2003 • 367 citations

Conjugates of Catecholamines with Cysteine and GSH in Parkinson's Disease: Possible Mechanisms of Formation Involving Reactive Oxygen Species

1998 • 366 citations

Acetylcholine, Aging, and Alzheimer's Disease

1997 • 355 citations

The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach

1998 • 352 citations

Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compounds

2005 • 346 citations

A Necessity for MAP Kinase Activation in Mammalian Spatial Learning

1999 • 346 citations

Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer's disease

1998 • 341 citations

MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide

2002 • 338 citations

EVOLUTIONARY AND MECHANISTIC THEORIES OF AGING

2004 • 338 citations

Fruit and vegetable consumption and risk of stroke

2005 • 335 citations

Microglia in the Aging Brain

2006 • 323 citations

An inflammatory review of Parkinson’s disease

2002 • 318 citations

Modulation of Hippocampal Plasticity and Cognitive Behavior by Short-term Blueberry Supplementation in Aged Rats

2004 • 299 citations

Alzheimer's disease – synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts

1998 • 292 citations

Patterns of Motor Impairment in Normal Aging, Mild Cognitive Decline, and Early Alzheimer' Disease

1997 • 277 citations

Microarray Profiling of Gene Expression in Aging and Its Alteration by Caloric Restriction in Mice

2001 • 267 citations

Pathobiology of the Aging Rat

1993 • 252 citations

Neuroinflammatory processes are important in neurodegenerative diseases: an hypothesis to explain the increased formation of reactive oxygen and nitrogen species as major factors involved in neurodegenerative disease development

1999 • 248 citations

Age-Related Activation of Microglia and Astrocytes: In Vitro Studies Show Persistent Phenotypes of Aging, Increased Proliferation, and Resistance to Down-Regulation

1998 • 246 citations

Regional distribution of cyclooxygenase-2 in the hippocampal formation in Alzheimer's disease

1999 • 243 citations

Degradation Products of Cyanidin Glycosides from Tart Cherries and Their Bioactivities

2001 • 240 citations

ICAM-1, VCAM-1, and MAdCAM-1 are expressed on choroid plexus epithelium but not endothelium and mediate binding of lymphocytes in vitro.

1996 • 238 citations

Inhibition of ERK and p38 MAP Kinases Inhibits Binding of Nrf2 and Induction of GCS Genes

2000 • 237 citations

The role of diet in cognitive decline

2003 • 234 citations

Enlarged and phagocytic, but not primed, interleukin-1α-immunoreactive microglia increase with age in normal human brain

1998 • 226 citations

Dissociation of Hippocampal and Striatal Contributions to Spatial Navigation in the Water Maze

1996 • 223 citations

Calorie restriction inhibits the age-related dysregulation of the cytokines TNF-α and IL-6 in C3B10RF1 mice

1997 • 221 citations

Inhibitory effects of blueberry extract on the production of inflammatory mediators in lipopolysaccharide‐activated BV2 microglia

2007 • 219 citations

Cerebral pattern of pro- and anti-inflammatory cytokines in dementias

2003 • 218 citations

Blueberry Supplemented Diet: Effects on Object Recognition Memory and Nuclear Factor-kappa B Levels in Aged Rats

2004 • 212 citations

Increased microglial activation and protein nitration in white matter of the aging monkey☆

1999 • 209 citations

Characterization, Quantification, and Bioactivities of Anthocyanins in Cornus Species

2002 • 207 citations

Dietary Flavonoids as Potential Neuroprotectants

2002 • 206 citations

Copernicus revisited: amyloid beta in Alzheimer's disease

2001 • 203 citations

Fruit Polyphenolics and Brain Aging

2002 • 200 citations

Nutritional Antioxidants Mechanisms of Action, Analyses of Activities and Medical Applications

2001 • 199 citations

Effects of Concord grape juice on cognitive and motor deficits in aging

2006 • 195 citations

Cytokine Gene Expression as a Function of the Clinical Progression of Alzheimer Disease Dementia

2000 • 192 citations

Redox active calcium ion channels and cell death

2004 • 184 citations

Inhibition of COX‐2 reduces the age‐dependent increase of hippocampal inflammatory markers, corticosterone secretion, and behavioral impairments in the rat

2002 • 176 citations

Beneficial effects of fruit extracts on neuronal function and behavior in a rodent model of accelerated aging

2006 • 167 citations

Psychomotor and spatial memory performance in aging male Fischer 344 rats

1998 • 156 citations

Spatial Learning and Memory Deficits Induced by Exposure to Iron-56-Particle Radiation

2000 • 153 citations

Ras-related and MAPK signalling in neuronal plasticity and memory formation

2000 • 151 citations

The effects of a novel NSAID on chronic neuroinflammation are age dependent☆

1999 • 148 citations

Essential Roles of Receptor-Interacting Protein and TRAF2 in Oxidative Stress-Induced Cell Death

2004 • 145 citations

Cytokine production in the central nervous system

1995 • 142 citations

Protein kinases: which one is the memory molecule?

1999 • 141 citations

Cytokine-induced expression of vascular cell adhesion molecule-1 (VCAM-1) by astrocytes and astrocytoma cell lines.

1995 • 140 citations

Astrocytes, brain aging, and neurodegeneration

1996 • 139 citations

Possible Äccelerated Striatal Aging" Induced by 56 Fe Heavy-Particle Irradiation: Implications for Manned Space Flights

1992 • 135 citations

Psychomotor performance in the senescent rodent: reduction of deficits via striatal dopamine receptor up-regulation

1983 • 135 citations

Feeding Rats Diets Enriched in Lowbush Blueberries for Six Weeks Decreases Ischemia-induced Brain Damage

2002 • 132 citations

Age-related hippocampal changes in Bcl-2:Bax ratio, oxidative stress, redox-active iron and apoptosis associated with aluminum-induced neurodegeneration: increased susceptibility with aging.

1999 • 131 citations

A unifying view of ageing and disease: the double-agent theory

2003 • 125 citations

Modulation of ion channels by reactive oxygen and nitrogen species: a pathophysiological role in brain aging?

2002 • 118 citations

Cytokines and the aging brain – what we don't know might help us

2004 • 117 citations

Cognitive decline associated with normal aging in rats: a neuropsychological approach.

1995 • 115 citations

Cyclin D1 and Cyclin E Are Co-Localized with Cyclo-Oxygenase 2 (COX-2) in Pyramidal Neurons in Alzheimer Disease Temporal Cortex

2002 • 114 citations

Behavioral and ultrastructural changes induced by chronic neuroinflammation in young rats

2000 • 111 citations

Motor learning deficits in aged rats are correlated with loss of cerebellar noradrenergic function

1993 • 109 citations

Strategies Used by Hippocampal- and Caudate-Putamen-Lesioned Rats in a Learning Task

1997 • 106 citations

Nitric oxide induces heme oxygenase-1 via mitogen-activated protein kinases ERK and p38.

2000 • 105 citations

Delphinidin inhibits endothelial cell proliferation and cell cycle progression through a transient activation of ERK-1/-2

2003 • 96 citations

Dietary supplementation with fruit polyphenolics ameliorates age-related deficits in behavior and neuronal markers of inflammation and oxidative stress

2005 • 94 citations

BCL-2 family members in the development and degenerative pathologies of the nervous system

1998 • 93 citations

Nutritional Factors in Cerebral Aging and Dementia: Epidemiological Arguments for a Role of Oxidative Stress

2001 • 92 citations

Effects of aging on cerebellar noradrenergic function and motor learning: nutritional interventions

1999 • 92 citations

Investigations on oxidative stress and therapeutical implications in dementia

1999 • 91 citations

Drugs to Treat Age‐Related Neurodegenerative Problems The Final Frontier of Medical Science?

1990 • 88 citations

Impaired acquisition of novel locomotor tasks in aged and norepinephrine-depleted F344 rats

1992 • 87 citations

Interleukin-1 Enhances the ATP-Evoked Release of Arachidonic Acid from Mouse Astrocytes

1997 • 86 citations

Brain dysfunction associated with an induction of nitric oxide synthase following an intracerebral injection of lipopolysaccharide in rats

1999 • 83 citations

AGE-RELATED NEURODEGENERATION AND OXIDATIVE STRESS

1998 • 80 citations

Aging‐ and Oxygen‐induced Modifications in Brain Biochemistry and Behavior^a

1994 • 79 citations

Flavonoid Phytochemicals Regulate Activator Protein-1 Signal Transduction Pathways in Endometrial and Kidney Stable Cell Lines

2002 • 78 citations

Peripheral administration of novel anti-inflammatories can attenuate the effects of chronic inflammation within the CNS

1999 • 78 citations

The effects of aging and oxidative stress on psychomotor and cognitive behavior

1999 • 76 citations

Neuroglial-mediated immunoinflammatory responses in Alzheimer's disease: Complement activation and therapeutic approaches

1996 • 70 citations

CNS-induced deficits of heavy particle irradiation in space: The aging connection

2000 • 67 citations

Neurons reduce glial responses to lipopolysaccharide (LPS) and prevent injury of microglial cells from over‐activation by LPS

2001 • 63 citations

Membrane and Receptor Modifications of Oxidative Stress Vulnerability in Aging: Nutritional Considerations

1998 • 63 citations

Cyclooxygenase Inhibitory and Antioxidant Compounds from Crabapple Fruits

2003 • 61 citations

The putative role of free radicals in the loss of neuronal functioning in senescence

1992 • 59 citations

CNS effects of heavy particle irradiation in space: Behavioral implications

1998 • 55 citations

Effects of exposure to different types of radiation on behaviors mediated by peripheral or central systems

1998 • 55 citations

Differential effects of protein kinase inhibitors and activators on memory formation in the 2-day-old chick

1994 • 53 citations

The effect of aging and an oxidative stress on peroxide levels and the mitochondrial membrane potential in isolated rat hepatocytes

1999 • 48 citations

Dietary antioxidants and human immune function

2000 • 47 citations

Magnetic resonance microscopy of iron in the basal forebrain cholinergic structures of the aged mouse lemur

1999 • 44 citations

Age-Related Increase of Brain Cyclooxygenase Activity and Dietary Modulation of Oxidative Status

2001 • 42 citations

Qualitative versus quantitative caloric intake: are they equivalent paths to successful aging?

2002 • 41 citations

Inflammatory mechanisms and anti-inflammatory therapy in Alzheimer's disease

1996 • 35 citations

The Relationship of Aging to Endotoxin Shock and to Production of TNF-

1996 • 35 citations

Differential Effect of Aging on Cholesterol Modulation of Carbachol-Stimulated Low-Km GTPase in Striatal Synaptosomes

1998 • 32 citations