Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: implications for the pathogenesis of neurodegenerative diseases.

Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+

1995 • 5,025 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

2000 • 3,415 citations

Reactive Oxygen Species and the Central Nervous System

1992 • 2,931 citations

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

2000 • 2,344 citations

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

1995 • 1,892 citations

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

1997 • 1,848 citations

Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor

2002 • 1,771 citations

Endonuclease G is an apoptotic DNase when released from mitochondria

2001 • 1,725 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

Apoptosis in neurodegenerative disorders

2000 • 1,542 citations

Organelle-specific initiation of cell death pathways

2001 • 1,454 citations

Role of calcium ions in regulation of mammalian intramitochondrial metabolism

1990 • 1,369 citations

Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria

1985 • 1,201 citations

Coupling endoplasmic reticulum stress to the cell death program

2004 • 1,172 citations

Microdomains with High Ca ²⁺ Close to IP ₃ -Sensitive Channels that Are Sensed by Neighboring Mitochondria

1993 • 1,167 citations

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines

2002 • 1,009 citations

Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine

1996 • 868 citations

Superoxide in Apoptosis

1998 • 773 citations

Superoxide dismutase delays neuronal apoptosis: A role for reactive oxygen species in programmed neuronal death

1995 • 744 citations

Requirement for Caspase-2 in Stress-Induced Apoptosis Before Mitochondrial Permeabilization

2002 • 727 citations

The mitochondrial-lysosomal axis theory of aging

2002 • 710 citations

Bax-induced Cytochrome C Release from Mitochondria Is Independent of the Permeability Transition Pore but Highly Dependent on Mg2+ Ions

1998 • 645 citations

Glutamate-induced neuron death requires mitochondrial calcium uptake

1998 • 623 citations

Increased Sensitivity to N-Methyl-D-Aspartate Receptor-Mediated Excitotoxicity in a Mouse Model of Huntington's Disease

2002 • 603 citations

Coupling Endoplasmic Reticulum Stress to the Cell Death Program

2001 • 584 citations

AnIn VitroModel of Parkinson's Disease: Linking Mitochondrial Impairment to Altered α-Synuclein Metabolism and Oxidative Damage

2002 • 575 citations

Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons

1993 • 569 citations

Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death?

2002 • 490 citations

Coupling Endoplasmic Reticulum Stress to the Cell Death Program

2002 • 480 citations

Requirement for Superoxide in Excitotoxic Cell Death

1996 • 437 citations

Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease

2000 • 433 citations

Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria

2002 • 432 citations

Calcium and reactive oxygen species mediate staurosporine-induced mitochondrial dysfunction and apoptosis in PC12 cells

1998 • 382 citations

Mitochondrial Depolarization Accompanies Cytochrome cRelease During Apoptosis in PC6 Cells

1999 • 347 citations

Calpain Activation in Huntington's Disease

2002 • 321 citations

Bcl-2 Prevents Bax Oligomerization in the Mitochondrial Outer Membrane

2001 • 320 citations

Does insulin dysfunction play a role in Alzheimer's disease?

2002 • 315 citations

Mitochondrial Membrane Potential and Glutamate Excitotoxicity in Cultured Cerebellar Granule Cells

2000 • 308 citations

AMPA Exposures Induce Mitochondrial Ca²⁺Overload and ROS Generation in Spinal Motor NeuronsIn Vitro

2000 • 307 citations

Functional Consequences of the Sustained or Transient Activation by Bax of the Mitochondrial Permeability Transition Pore

1999 • 295 citations

Proteasome-mediated Degradation of Smac during Apoptosis: XIAP Promotes Smac Ubiquitination in Vitro

2002 • 294 citations

Formation and Removal of α-Synuclein Aggregates in Cells Exposed to Mitochondrial Inhibitors

2002 • 292 citations

Insulin Rescues Retinal Neurons from Apoptosis by a Phosphatidylinositol 3-Kinase/Akt-mediated Mechanism That Reduces the Activation of Caspase-3

2001 • 288 citations

Proapoptotic BH3-only Bcl-2 family members induce cytochromecrelease, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity

2000 • 273 citations

Overexpression of Copper/Zinc Superoxide Dismutase in Transgenic Rats Protects Vulnerable Neurons against Ischemic Damage by Blocking the Mitochondrial Pathway of Caspase Activation

2002 • 267 citations

Oxidative stress-induced apoptosis prevented by trolox

1994 • 266 citations

Neuroprotection by memantine against neurodegeneration induced by β-amyloid(1–40)

2002 • 266 citations

Mitochondria Recycle Ca2+ to the Endoplasmic Reticulum and Prevent the Depletion of Neighboring Endoplasmic Reticulum Regions

2001 • 262 citations

Autophagic Cell Death and Its Execution by Lysosomal Cathepsins.

2001 • 234 citations

Delayed Mitochondrial Dysfunction in Excitotoxic Neuron Death: CytochromecRelease and a Secondary Increase in Superoxide Production

2000 • 233 citations

Effect of the overexpression of wild‐type or mutant α‐synuclein on cell susceptibility to insult

2001 • 227 citations

Shift of the Cellular Oxidation‐Reduction Potential in Neural Cells Expressing Bcl‐2

1996 • 221 citations

Excitatory Amino Acid‐Mediated Cytotoxicity and Calcium Homeostasis in Cultured Neurons

1993 • 219 citations

Activation of Bcl-2-Associated Death Protein and Counter-Response of Akt within Cell Populations during Seizure-Induced Neuronal Death

2002 • 204 citations

Cytochrome c Is Released from Mitochondria in a Reactive Oxygen Species (ROS)-dependent Fashion and Can Operate as a ROS Scavenger and as a Respiratory Substrate in Cerebellar Neurons Undergoing Excitotoxic Death

2000 • 202 citations

Mitochondrial Control of Acute Glutamate Excitotoxicity in Cultured Cerebellar Granule Cells

1998 • 199 citations

Functional mitochondria are required for amyloid β‐mediated neurotoxicity

2001 • 198 citations

Calcineurin-Mediated BAD Dephosphorylation Activates the Caspase-3 Apoptotic Cascade in Traumatic Spinal Cord Injury

2000 • 196 citations

Ca(2+)-induced mitochondrial membrane permeabilization: role of coenzyme Q redox state

1995 • 187 citations

Mitochondrial Depolarization Is Not Required for Neuronal Apoptosis

1999 • 184 citations

Privileged access to mitochondria of calcium influx through N-methyl-D-aspartate receptors.

1998 • 181 citations

Bid-induced Cytochrome c Release Is Mediated by a Pathway Independent of Mitochondrial Permeability Transition Pore and Bax

2000 • 179 citations

Transient Expression of Wild-type or Mitochondrially Targeted Bcl-2 Induces Apoptosis, whereas Transient Expression of Endoplasmic Reticulum-targeted Bcl-2 Is Protective against Bax-induced Cell Death

2001 • 178 citations

Effect of Wild-type or Mutant Parkin on Oxidative Damage, Nitric Oxide, Antioxidant Defenses, and the Proteasome

2002 • 174 citations

Huntingtin's Neuroprotective Activity Occurs via Inhibition of Procaspase-9 Processing

2001 • 164 citations

Staurosporine-Induced Apoptosis of Cultured Rat Hippocampal Neurons Involves Caspase-1-Like Proteases as Upstream Initiators and Increased Production of Superoxide as a Main Downstream Effector

1998 • 164 citations

Oxidative stress in Ca²⁺‐induced membrane permeability transition in brain mitochondria

2001 • 164 citations

Involvement of Activated Caspase‐3‐Like Proteases in N‐Methyl‐D‐Aspartate‐Induced Apoptosis in Cerebrocortical Neurons

2000 • 148 citations

α-Synuclein Lowers p53-dependent Apoptotic Response of Neuronal Cells

2002 • 133 citations

Cytochrome C and Caspase-9 Expression in Huntington 's Disease

2002 • 130 citations

Ca²⁺ and Reactive Oxygen Species in Staurosporine‐Induced Neuronal Apoptosis

1997 • 126 citations

Collapse of the Inner Mitochondrial Transmembrane Potential Is Not Required for Apoptosis of HL60 Cells

1999 • 124 citations

Amyloid β Peptide–Induced Cerebral Endothelial Cell Death Involves Mitochondrial Dysfunction and Caspase Activation

2001 • 123 citations

Effect of amyloid β‐peptide on permeability transition pore: A comparative study

2002 • 116 citations

Reactive Oxygen Species and the Central Nervous System

1992 • 116 citations

Modulation of Mitochondrial Ca2+ Homeostasis by Bcl-2

1999 • 112 citations

Role of the Mitochondrial Permeability Transition and Cytochrome c Release in Hydrogen Peroxide-Induced Apoptosis

2002 • 107 citations

The Mitochondrial Toxin 3-Nitropropionic Acid Induces Striatal Neurodegeneration via a c-Jun N-Terminal Kinase/c-Jun Module

2002 • 98 citations

The mechanism of mitochondrial membrane potential retention following release of cytochrome c in apoptotic GT1-7 neural cells

2001 • 88 citations

Calcium-dependent Cleavage of Endogenous Wild-type Huntingtin in Primary Cortical Neurons

2002 • 85 citations

Chaperoning brain diseases

1998 • 82 citations

Mitochondrial permeability transition and calcium dynamics in striatal neurons upon intense NMDA receptor activation

2002 • 77 citations

Confocal microscopy of the mitochondrial permeability transition in necrotic cell killing, apoptosis and autophagy

1998 • 71 citations

Inhibition of glutathione depletion by retinoic acid and tocopherol protects cultured neurons from staurosporine-induced oxidative stress and apoptosis

2000 • 68 citations

Kainate excitotoxicity in organotypic hippocampal slice cultures: evidence for multiple apoptotic pathways

2001 • 65 citations

Apoptosis Induced via AMPA‐Selective Glutamate Receptors in Cultured Murine Cortical Neurons

1997 • 65 citations

The Novel Presenilin-1-associated Protein Is a Proapoptotic Mitochondrial Protein

2002 • 63 citations

Mitochondria Control AMPA/Kainate Receptor-Induced Cytoplasmic Calcium Deregulation in Rat Cerebellar Granule Cells

2001 • 60 citations

Apocytochrome c Blocks Caspase-9 Activation and Bax-induced Apoptosis

2002 • 56 citations

Possible involvement of both mitochondria- and endoplasmic reticulum-dependent caspase pathways in rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells

2002 • 54 citations

Insulin Antiapoptotic Signaling Involves Insulin Activation of the Nuclear Factor κB-dependent Survival Genes Encoding Tumor Necrosis Factor Receptor-associated Factor 2 and Manganese-superoxide Dismutase

1999 • 54 citations

Neuronal apoptosis induced by endoplasmic reticulum stress.

2002 • 46 citations

AMPA Neurotoxicity in Cultured Cerebellar Granule Neurons: Mode of Cell Death

1997 • 44 citations

AMPA Receptor‐Mediated Excitotoxicity in Human NT2‐N Neurons Results from Loss of Intracellular Ca²⁺ Homeostasis Following Marked Elevation of Intracellular Na⁺

1998 • 41 citations

The Kinetics of Translocation of Smac/DIABLO from the Mitochondria to the Cytosol in HeLa Cells

2002 • 39 citations

Identification of an Axotomy-Induced Glycosylated Protein, AIGP1, Possibly Involved in Cell Death Triggered by Endoplasmic Reticulum–Golgi Stress

2002 • 34 citations

The mitochondrial toxin 3‐nitropropionic acid induces differential expression patterns of apoptosis‐related markers in rat striatum

2001 • 30 citations

Mitochondrial apoptotic cell death and moderate superoxide generation upon selective activation of non‐desensitizing AMPA receptors in hippocampal cultures

2003 • 24 citations

The Difference between Mechanisms of Kainate and Glutamate Excitotoxicity In Vitro: Osmotic Lesion Versus Mitochondrial Depolarization

1998 • 23 citations

Glutamate-mediated inhibition of oxidative phosphorylation in cultured retinal cells

2000 • 21 citations

Functional consequences of the sustained or transient activation by Bax of the mitochondrial permeability transition pore.

2000 • 17 citations