The putative role of free radicals in the loss of neuronal functioning in senescence

Free radicals in biology and medicine

1991 • 17,840 citations

A JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

1909 • 6,516 citations

The Cholinergic Hypothesis of Geriatric Memory Dysfunction

1982 • 5,422 citations

Free Radicals in Biology and Medicine

1990 • 4,962 citations

Inositol phosphates and cell signalling

1989 • 4,058 citations

D ₁ and D ₂ Dopamine Receptor-regulated Gene Expression of Striatonigral and Striatopallidal Neurons

1990 • 2,873 citations

Society for Neuroscience 2007 abstracts

2007 • 2,107 citations

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine

1991 • 2,008 citations

Handbook of the Psychology of Aging

1978 • 1,980 citations

The aging process.

1981 • 1,871 citations

Handbook of the Psychology of Aging

1986 • 1,567 citations

NMDA receptors - their role in long-term potentiation

1987 • 1,177 citations

Oxidants and human disease: some new concepts ¹

1987 • 1,171 citations

Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1

1991 • 1,157 citations

Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors

1984 • 905 citations

Comparison of Two Forms of Long-Term Potentiation in Single Hippocampal Neurons

1990 • 755 citations

Excitatory amino acids in the brain - focus on NMDA receptors

1987 • 641 citations

In situ injection of kainic acid: A new method for selectively lesioning neuronal cell bodies while sparing axons of passage

1978 • 599 citations

Cholinergic mechanisms in learning, memory and dementia: a review of recent evidence

1991 • 598 citations

The molecular basis of muscarinic receptor diversity

1989 • 544 citations

Receptor-mediated activation of phospholipase A2 via GTP-binding proteins: arachidonic acid and its metabolites as second messengers

1988 • 512 citations

Contributions of Quisqualate and NMDA Receptors to the Induction and Expression of LTP

1988 • 512 citations

Striatal lesions with kainic acid: neurochemical characteristics

1977 • 461 citations

Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake

1990 • 424 citations

Physiological mechanisms underlying long-term potentiation

1988 • 405 citations

Spontaneous calcium release from inositol trisphosphate-sensitive calcium stores

1991 • 366 citations

Receptor Activation and Inositol Lipid Hydrolysis in Neural Tissues

1987 • 341 citations

Heterogeneity of presynaptic muscarinic receptors regulating neurotransmitter release in the rat brain.

1984 • 312 citations

Oxygen free radicals and Parkinson's disease

1991 • 293 citations

Somatosensory inattention after dopamine-depleting intracerebral 6-OHDA injections: Spontaneous recovery and pharmacological control

1979 • 279 citations

Differences in human memory with aging: Nature, causes, and clinical implications.

1985 • 277 citations

Age-Related Changes in Passive Avoidance Retention: Modulation with Dietary Choline

1980 • 271 citations

Movement Disorders of Aged Rats: Reversal by Dopamine Receptor Stimulation

1979 • 207 citations

Reduced Phosphoinositide Concentrations in Anterior Temporal Cortex of Alzheimer‐Diseased Brains

1987 • 201 citations

Behavioral and anatomical consequences of small intrastriatal injections of kainic acid in the rat

1978 • 198 citations

Motor and Reflexive Behavior in the Aging Rat

1980 • 197 citations

Age-related Changes in the Nigrostriatum: A Behavioral and Biochemical Analysis

1978 • 197 citations

Age-related differences in behavior across the life span of the C57BL/6J mouse

1981 • 196 citations

Experimental Psychology and Human Aging

1983 • 193 citations

Behavioral effects of MK-801 mimic deficits associated with hippocampal damage

1989 • 190 citations

Developmental and age-related changes in D1-dopamine receptors and dopamine content in the rat striatum

1987 • 175 citations

NMDA antagonist MK-801 impairs acquisition but not performance of spatial working and reference memory

1990 • 170 citations

Experimental Psychology and Human Aging

1983 • 160 citations

Signal transduction by G proteins

1990 • 159 citations

Free radicals and tardive dyskinesia

1986 • 151 citations

Loss of high‐affinity agonist binding to M1 muscarinic receptors in Alzheimer's disease: Implications for the failure of cholinergic replacement therapies

1991 • 145 citations

Fine structural changes in the rat striatum after local injections of kainic acid

1977 • 142 citations

Stimulation of D2-dopamine receptors in rat neostriatum inhibits the release of acetylcholine and dopamine but does not affect the release of γ-aminobutyric acid, glutamate or serotonin

1982 • 142 citations

Further evidence for the involvement of D2, but not D1 dopamine receptors in dopaminergic control of striatal cholinergic transmission

1982 • 141 citations

A novel NMDA antagonist, MK-801, impairs performance in a hippocampal-dependent spatial learning task

1989 • 141 citations

Psychomotor performance in the senescent rodent: reduction of deficits via striatal dopamine receptor up-regulation

1983 • 135 citations

Possible Äccelerated Striatal Aging" Induced by 56 Fe Heavy-Particle Irradiation: Implications for Manned Space Flights

1992 • 135 citations

Role of membrane lipid asymmetry in aging

1984 • 131 citations

Molecular Pharmacology

2008 • 128 citations

Review of Biological Research in Aging

1984 • 127 citations

Pharmacological alleviation of cholinergic lesion induced memory deficits in rats

1985 • 117 citations

Effect of aging on concentrations of D2-receptor-containing neurons in the rat striatum

1989 • 103 citations

Decreased brain [3H]inositol 1,4,5-trisphosphate binding in Alzheimer's disease

1988 • 102 citations

Differential expression of the mouse D₂ dopamine receptor isoforms

1991 • 99 citations

The effect of aging on the D1 dopamine receptors in human frontal cortex

1990 • 94 citations

Aging and brain cholinergic muscarinic receptor subtypes: An autoradiographic study in the rat

1989 • 90 citations

Drugs to Treat Age‐Related Neurodegenerative Problems The Final Frontier of Medical Science?

1990 • 88 citations

Senescent pathology of cerebellum: Purkinje neurons and their parallel fiber afferents

1981 • 87 citations

Divergent changes in D-1 and D-2 dopamine binding sites in human brain during aging

1987 • 82 citations

Evidence for dopamine D-2 receptors on cholinergic interneurons in the rat caudate-putamen

1988 • 81 citations

Conformational changes in muscarinic receptors may produce diminished cholinergic neurotransmission and memory deficits in aged rats

1985 • 81 citations

Loss of striatal dopaminergic receptors after intrastriatal kainic acid injection

1978 • 79 citations

Loss of D2 receptors during aging is partially due to decreased levels of mRNA

1991 • 75 citations

Age-related decrements in the muscarinic enhancement of K+-evoked release of endogenous striatal dopamine: an indicator of altered cholinergic-dopaminergic reciprocal inhibitory control in senescence

1988 • 74 citations

Age Related Decrease in the Density of Dopamine D₁ and D₂ Receptors in Corpus Striatum of Rats

1987 • 71 citations

Prehistoric Irrigation Systems in the Salt River Valley, Arizona

1981 • 71 citations

3H-clozapine binding to rat brain membranes

1978 • 67 citations

Guanine nucleotide modulation of muscarinic cholinergic receptor binding in postmortem human brain — A preliminary study in Alzheimer's disease

1987 • 64 citations

Tetrahydroaminoacridine, 3,4 diaminopyridine and physostigmine: Direct comparison of effects on memory in aged primates

1988 • 62 citations

The dopamine and serotonin systems during aging in human and rodent brain. A brief review

1987 • 62 citations

Diminished Beta-Adrenergic Modulation of Cardiovascular Function in Advanced Age

1986 • 62 citations

Alterations in muscarinic control of striatal dopamine autoreceptors in senescence: a deficit at the ligand-muscarinic receptor interface?

1988 • 60 citations

Role of cyclic AMP-dependent protein kinase in the diminished beta adrenergic responsiveness of vascular smooth muscle with increasing age.

1989 • 59 citations

Selective cross-activation/inhibition of second messenger systems and the reduction of age-related deficits in the muscarinic control of dopamine release from perifused rat striata

1990 • 58 citations

Age-related alteration in excitatory amino acid neurotransmission in rat brain

1990 • 51 citations

Aging does not alter brain muscarinic receptor-mediated phosphoinositide hydrolysis and its inhibition by phorbol esters, tetrodotoxin and receptor desensitization.

1989 • 51 citations

The effect of NMDA antagonists in the radial arm maze task with an interposed delay

1990 • 50 citations

Alzheimer's disease: is there a problem beyond recognition?

1990 • 50 citations

Decrement of muscarinic receptor-stimulated low-KMGTPase in striatum and hippocampus from the aged rat

1992 • 50 citations

Effect of acute arecoline, tacrine and arecoline + tacrine post-training administration on retention in old mice

1988 • 48 citations

Upregulation of Striatal Dopamine Receptors and Improvement of Motor Performance in Senescence

1988 • 42 citations

Decreased efficacy of inositol 1,4,5-trisphosphate to elicit calcium mobilization from cerebrocortical microsomes of aged rats.

1990 • 39 citations

Effect of aging on striatal dopamine receptor subtype recovery following N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline blockade and relation to motor function in Wistar rats

1987 • 35 citations

Intracellular neurophysiological analysis reveals alterations in excitation in striatal neurons in aged rats

1989 • 34 citations

Muscarinic acetylcholine receptor subtype mRNA expression and ligand binding in the aged rat forebrain

1991 • 34 citations

Changes in receptor stimulated phosphoinositide hydrolysis in brain during ethanol administration, aging, and other pathological conditions.

1986 • 32 citations

Plasticity of neostriatal metabolic activity and behavioral recovery from nigrostriatal injury

1981 • 31 citations

Antioxidant Therapy in Parkinson's Disease

1987 • 31 citations

Cloning of a ‘D3’ receptor subtype expands dopamine receptor family

1991 • 30 citations

Comparison of Age-Related Changes in Prostaglandin E1 and Beta-Adrenergic Responsiveness of Vascular Smooth Muscle in Adult Males

1989 • 29 citations

Ionizing Radiation and Aging

1960 • 28 citations

Kainic acid-induced neurotoxicity in the striatum: A histofluorescent study

1979 • 22 citations

Muscarinic receptor concentrations and dopamine release in aged rat striata

1992 • 22 citations

Selective susceptibility of cultured striatal neurons to kainic acid

1992 • 21 citations

Senescence does not alter activation or inhibition of striatal adenylate cyclase

1986 • 19 citations

Altered Striatal Dopaminergic and Cholinergic Reciprocal Inhibitory Control and Motor Behavioral Decrements in Senescence

1988 • 19 citations

Aging does not alter muscarinic receptor-mediated inhibition of cyclic AMP formation in the striatum and hippocampus

1990 • 15 citations

Central Determinants of Age-Related Declines in Motor Function (Annals of the New York Academy of Sciences. Volume 515)

1988 • 15 citations

The deleterious effects of aging and kainic acid may be selective for similar striatal neuronal populations

1991 • 14 citations

Age-related Changes in Cerebellar Noradrenergic Function

1988 • 14 citations

Guanine Nucleotide Binding Proteins and Signal Transduction

1988 • 12 citations

Sensorimotor deficits produced by phenytoin and chlorpromazine in unanesthetized cats

1979 • 9 citations

Roles of G proteins and G protein subunits in signal transduction.

1990 • 9 citations

Complex Maze Learning in Rodents

1990 • 8 citations

On the Origins and Present State of the Art of G Protein Research

1991 • 7 citations

Deleted Work

1955 • 0 citations