Differential Effect of Aging on Cholesterol Modulation of Carbachol-Stimulated Low-Km GTPase in Striatal Synaptosomes

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES

1957 • 63,238 citations

Two dimensional thin layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots

1970 • 3,260 citations

Oxidative Stress, Caloric Restriction, and Aging

1996 • 3,136 citations

Laboratory techniques in biochemistry and molecular biology

1973 • 2,129 citations

Fluidity parameters of lipid regions determined by fluorescence polarization

1978 • 1,886 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

Heterotrimeric C proteins: Organizers of transmembrane signals

1995 • 1,388 citations

A rapid and sensitive sub-micro phosphorus determination

1961 • 951 citations

Cholesterol and the Golgi Apparatus

1993 • 819 citations

Catecholamine-stimulated GTPase activity in turkey erythrocyte membranes

1976 • 623 citations

Phospholipid signaling

1995 • 561 citations

Sphingomyelins in bilayers and biological membranes

1980 • 367 citations

Alterations in mitochondrial membrane fluidity by lipid peroxidation products

1994 • 367 citations

α‐Linolenic Acid Dietary Deficiency Alters Age‐Related Changes of Dopaminergic and Serotoninergic Neurotransmission in the Rat Frontal Cortex

1996 • 336 citations

Depletion of plasma-membrane sphingomyelin rapidly alters the distribution of cholesterol between plasma membranes and intracellular cholesterol pools in cultured fibroblasts

1988 • 323 citations

Heterotrimeric G proteins

1996 • 318 citations

Arachidonic acid as a neurotoxic and neurotrophic substance

1995 • 275 citations

Sphingomyelin and derivatives as cellular signals

1991 • 275 citations

Age‐Related Differences in Synaptosomal Peroxidative Damage and Membrane Properties

1991 • 174 citations

Decreased Catalase Activity but Unchanged Superoxide Dismutase Activity in Brains of Patients with Dementia of Alzheimer Type

1995 • 168 citations

Structural and functional relationships of heterotrimeric G‐proteins

1995 • 160 citations

Increasing Age Alters Transbilayer Fluidity and Cholesterol Asymmetry in Synaptic Plasma Membranes of Mice

1996 • 157 citations

Membrane alterations as causes of impaired signal transduction in Alzheimer's disease and aging

1995 • 155 citations

Brain synaptosomal aging: Free radicals and membrane fluidity

1995 • 147 citations

Attenuation of channel kinetics and conductance by cholesterol: An interpretation using structural stress as a unifying concept

1995 • 140 citations

Lipid peroxidation contributes to age-related membrane rigidity

1995 • 138 citations

Effects of sphingomyelin degradation on cell cholesterol oxidizability and steady-state distribution between the cell surface and the cell interior

1989 • 136 citations

Role of membrane lipid asymmetry in aging

1984 • 131 citations

Function of dietary polyunsaturated fatty acids in the nervous system

1993 • 122 citations

Phospholipids and acyl groups of synaptosomal and myelin membranes isolated from the cerebral cortex of squirrel monkey (Saimiri sciureus)

1972 • 119 citations

Ceramide Induces Structural Defects into Phosphatidylcholine Bilayers and Activates Phospholipase A2

1996 • 113 citations

Lipid modulation of nicotinic acetylcholine receptor function: the role of membrane lipid composition and fluidity

1994 • 106 citations

Possible role for glycosphingolipids in the control of immune responses

1979 • 93 citations

Effective tumor immunization induced by cells of elevated membrane-lipid microviscosity.

1979 • 89 citations

Age-associated changes in the content and fatty acid composition of brain glycerophospholipids

1995 • 84 citations

Aging‐ and Oxygen‐induced Modifications in Brain Biochemistry and Behavior^a

1994 • 79 citations

Biochemical changes of rat brain membranes with aging

1983 • 74 citations

Age differences in sensitivity to H2O2- or no-induced reductions in K+-evoked dopamine release from superfused striatal slices: Reversals by PBN or Trolox

1996 • 72 citations

Effects of aging on the content, composition and synthesis of sphingomyelin in the central nervous system

1992 • 68 citations

Asymmetry of membrane fluidity in the lipid bilayer of blood platelets: Fluorescence study with diphenylhexatriene and analogs

1991 • 65 citations

Developmental changes in synaptic membrane lipid composition and fluidity

1983 • 62 citations

Selective cross-activation/inhibition of second messenger systems and the reduction of age-related deficits in the muscarinic control of dopamine release from perifused rat striata

1990 • 58 citations

Iron/ascorbate-induced lipid peroxidation changes membrane fluidity and muscarinic cholinergic receptor binding in rat frontal cortex

1993 • 58 citations

Aging and food restriction: Effect on lipids of cerebral cortex

1991 • 56 citations

Relationships between membrane lipid composition and biological properties of rat myocytes. Effects of aging and manipulation of lipid composition.

1985 • 56 citations

Membrane Viscosity Correlates with α₁‐Adrenergic Signal Transduction of the Aged Rat Cerebral Cortex

1990 • 55 citations

Cholesterol protects the phospholipid bilayer from oxidative damage

1995 • 54 citations

Age‐related changes in Δ6 and Δ5 desaturase activities in rat liver microsomes

1993 • 54 citations

Decrement of muscarinic receptor-stimulated low-KMGTPase in striatum and hippocampus from the aged rat

1992 • 50 citations

Lipid Modulation of Cell Function

1993 • 48 citations

Upregulation of Striatal Dopamine Receptors and Improvement of Motor Performance in Senescence

1988 • 42 citations

Sphingosine and Sphingosine 1-Phosphate Differentially Modulate Platelet-derived Growth Factor-BB-induced Ca2+ Signaling in Transformed Oligodendrocytes

1996 • 41 citations

Cholesterol: A Two-Edged Sword in Brain Aging

1997 • 39 citations

Increased steroid hormone secretion in mouse Leydig tumor cells after induction of cholesterol translocation by sphingomyelin degradation

1991 • 37 citations

Disrupted β1-adrenoceptor—G protein coupling in the temporal cortex of patients with Alzheimer's disease

1993 • 34 citations

Age-dependent modification of lipid composition and lipid structural order parameter of rat peritoneal macrophage membranes

1993 • 33 citations

Acanthocytosis and cholesterol enrichment decrease lipid fluidity of only the outer human erythrocyte membrane leaflet

1982 • 33 citations

Changes in lipid composition of cortical synaptosomes from different age groups of mice

1984 • 30 citations

The effects of aging on muscarinic receptor/G-protein coupling in the rat hippocampus and striatum

1992 • 29 citations

Dissociation of Striatal GTPase and Dopamine Release Responses to Muscarinic Cholinergic Agonists in F344 Rats: Influence of Age and Dietary Manipulation

1995 • 26 citations

Age-specific alterations in muscarinic stimulation of K+-evoked dopamine release from striatal slices by cholesterol andS-adenosyl-l-methionine

1995 • 23 citations

Kinetics and size of cholesterol lateral domains in synaptosomal membranes: Modification by sphingomyelinase and effects on membrane enzyme activity

1993 • 23 citations

Differential coupling between muscarinic receptors and G-proteins in regions of the rat brain

1990 • 23 citations

Aging and Food Restriction

1963 • 16 citations

Influence of aging on fluidity and coupling between β-receptors and G-proteins in rat lung membranes

1993 • 15 citations

The negative coupling between serotonin and muscarinic receptor(s) for arachidonic acid and inositol phosphates release in brain cortex synaptoneurosomes. Effect of aging

1995 • 11 citations

Effect of specific membrane perturbations on alpha1-adrenergic and muscarinic-cholinergic signal transduction in rat parotid cell aggregates

1994 • 11 citations

Alteration in the Reactivity of Sphingomyelin in Mitogen-Stimulated Lymphocytes1

1995 • 11 citations

Role of lipids in receptor mediated signal transduction.

1993 • 6 citations

Fatty acid composition of phospholipids of myelin and synaptosomal proteolipid complexes from vertebrate brain

1991 • 6 citations

α1-Adrenergic stimulation of low Km GTPase in rat striata is diminished with age

1992 • 6 citations

In vitro and in vivo ethanolamine metabolism in rat brain: Effect of time and aging

1992 • 3 citations