EVOLUTIONARY AND MECHANISTIC THEORIES OF AGING

Aging: A Theory Based on Free Radical and Radiation Chemistry

1956 • 8,252 citations

The Ants

1990 • 4,858 citations

PLEIOTROPY, NATURAL SELECTION, AND THE EVOLUTION OF SENESCENCE

1957 • 4,140 citations

SUPEROXIDE RADICAL AND SUPEROXIDE DISMUTASES

1995 • 3,305 citations

A C. elegans mutant that lives twice as long as wild type

1993 • 3,250 citations

The moulding of senescence by natural selection

1966 • 2,252 citations

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

1997 • 2,174 citations

The Population Consequences of Life History Phenomena

1954 • 2,077 citations

Pleiotropy, Natural Selection, and the Evolution of Senescence

1957 • 1,765 citations

Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae

2000 • 1,756 citations

A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function

2001 • 1,583 citations

daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans

1997 • 1,468 citations

Extension of Life-Span by Overexpression of Superoxide Dismutase and Catalase in Drosophila melanogaster

1994 • 1,461 citations

Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor

2003 • 1,431 citations

Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

2001 • 1,398 citations

Longevity, senescence and the genome

1995 • 1,390 citations

The Endocrine Regulation of Aging by Insulin-like Signals

2003 • 1,342 citations

Genetic pathways that regulate ageing in model organisms

2000 • 1,341 citations

Evolutionary biology of aging

1991 • 1,333 citations

Evolution in Age-Structured Populations

1994 • 1,308 citations

Mitochondria, oxygen free radicals, disease and ageing

2000 • 1,054 citations

Signals from the reproductive system regulate the lifespan of C. elegans

1999 • 956 citations

Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics

2000 • 909 citations

The evolution of ageing and longevity

1979 • 875 citations

Handbook of the Biology of Aging

1978 • 871 citations

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

1996 • 870 citations

Regulation of Longevity and Stress Resistance by Sch9 in Yeast

2001 • 858 citations

Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons

1998 • 852 citations

Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress.

1995 • 847 citations

Extended Life-Span and Stress Resistance in the Drosophila Mutant methuselah

1998 • 815 citations

Evolution of ageing

2002 • 800 citations

LABORATORY EVOLUTION OF POSTPONED SENESCENCE INDROSOPHILA MELANOGASTER

1984 • 774 citations

Sir2 links chromatin silencing, metabolism, and aging

2000 • 725 citations

Thedaf‐2gene network for longevity regulates oxidative stress resistance and Mn‐superoxide dismutase gene expression inCaenorhabditis elegans

1999 • 721 citations

Regulation of Longevity inCaenorhabditis elegansby Heat Shock Factor and Molecular Chaperones

2003 • 697 citations

Two Pleiotropic Classes of daf-2 Mutation Affect Larval Arrest, Adult Behavior, Reproduction and Longevity in Caenorhabditis elegans

1998 • 691 citations

Pathological implications of nitric oxide, superoxide and peroxynitrite formation

1993 • 679 citations

Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals

2001 • 642 citations

Laboratory Evolution of Postponed Senescence in Drosophila melanogaster

1984 • 641 citations

Evolutionary Medicine: From Dwarf Model Systems to Healthy Centenarians?

2003 • 587 citations

Extraordinary lifespans in ants: a test of evolutionary theories of ageing

1997 • 586 citations

Genome-Wide Transcript Profiles in Aging and Calorically Restricted Drosophila melanogaster

2002 • 567 citations

SELECTION FOR DELAYED SENESCENCE IN DROSOPHILA MELANOGASTER

1984 • 562 citations

Regulation of lifespan by sensory perception in Caenorhabditis elegans

1999 • 554 citations

Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals

2000 • 536 citations

Demography of Dietary Restriction and Death in Drosophila

2003 • 531 citations

Determination of Life-Span in Caenorhabditis elegans by Four Clock Genes

1996 • 529 citations

A Conserved Regulatory System for Aging

2001 • 526 citations

Invited Review: Theories of aging

2003 • 508 citations

Mechanisms of aging: public or private?

2002 • 500 citations

Mitochondrial oxygen radical generation and leak: sites of production in states 4 and 3, organ specificity, and relation to aging and longevity.

1999 • 492 citations

AN ATTEMPT AT A RATIONAL CLASSIFICATION OF THEORIES OF AGEING

1990 • 490 citations

Extended Life-Span Conferred by Cotransporter Gene Mutations in Drosophila

2000 • 488 citations

[57] Determination of the production of superoxide radicals and hydrogen peroxide in mitochondria

1984 • 477 citations

FLP Recombinase-Mediated Induction of Cu/Zn-Superoxide Dismutase Transgene Expression Can Extend the Life Span of Adult Drosophila melanogaster Flies

1999 • 462 citations

The chronological life span of Saccharomyces cerevisiae

2003 • 455 citations

Mammalian Aging, Metabolism, and Ecology: Evidence From the Bats and Marsupials

1991 • 450 citations

The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans.

1995 • 442 citations

High-quality life extension by the enzyme peptide methionine sulfoxide reductase

2002 • 440 citations

Genetics and the Specificity of the Aging Process

2003 • 439 citations

Female fitness inDrosophila melanogaster: an interaction between the effect of nutrition and of encounter rate with males

1996 • 427 citations

Increased Life-Span of age -1 Mutants in Caenorhabditis elegans and Lower Gompertz Rate of Aging

1990 • 402 citations

Rethinking the evolutionary theory of aging: Transfers, not births, shape senescence in social species

2003 • 402 citations

Phenotypic plasticity and selection in Drosophila life history evolution. 2. Diet, mates and the cost of reproduction

1997 • 398 citations

Oxidative stress and ageing in Caenorhabditis elegans

1993 • 383 citations

Induced Overexpression of Mitochondrial Mn-Superoxide Dismutase Extends the Life Span of Adult Drosophila melanogaster

2002 • 374 citations

GENETICS OF LIFE HISTORY IN DROSOPHILA MELANOGASTER. I. SIB ANALYSIS OF ADULT FEMALES

1981 • 370 citations

Phenotypic plasticity and selection in Drosophila life‐history evolution. I. Nutrition and the cost of reproduction

1993 • 361 citations

The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach

1998 • 352 citations

A test of evolutionary theories of senescence

1980 • 349 citations

Evolutionary Theories of Aging: Confirmation of a Fundamental Prediction, with Implications for the Genetic Basis and Evolution of Life Span

1998 • 348 citations

SENESCENCE IN NATURAL POPULATIONS OF MAMMALS: A COMPARATIVE STUDY

1991 • 321 citations

Genome-wide study of aging and oxidative stress response inDrosophilamelanogaster

2000 • 315 citations

DIRECT AND CORRELATED RESPONSES TO SELECTION ON AGE AT REPRODUCTION INDROSOPHILA MELANOGASTER

1992 • 311 citations

Chemosensory Neurons Function in Parallel to Mediate a Pheromone Response in C. elegans

1996 • 311 citations

Selection on stress resistance increases longevity in Drosophila melanogaster

1992 • 304 citations

Dietary Restriction in Long-Lived Dwarf Flies

2002 • 292 citations

L. A problem in age-distribution

1911 • 281 citations

Experimental evolution of aging, growth, and reproduction in fruitflies

2000 • 281 citations

CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans

1999 • 274 citations

Longevity Regulation by Drosophila Rpd3 Deacetylase and Caloric Restriction

2002 • 274 citations

Superoxide Radical and Hydrogen Peroxide in Mitochondria

1982 • 273 citations

A Delayed Wave of Death from Reproduction in Drosophila

1999 • 272 citations

RESISTANCE TO ENVIRONMENTAL STRESS IN DROSOPHILA MELANOGASTER SELECTED FOR POSTPONED SENESCENCE

2004 • 270 citations

I<scp>NSECT</scp>B<scp>IODEMOGRAPHY</scp>

2001 • 267 citations

Evolutionary Biology of Aging

1990 • 267 citations

The Effects of Temperature and of Egg-Laying on the Longevity of Drosophila Subobscura

1958 • 264 citations

Patterns of Age-specific Means and Genetic Variances of Mortality Rates Predicted by the Mutation-Accumulation Theory of Ageing

2001 • 261 citations

DOES INCREASED MORTALITY FAVOR THE EVOLUTION OF MORE RAPID SENESCENCE?

1993 • 258 citations

Selection for life span in Drosophila melanogaster

1985 • 247 citations

Extension of Life-Span in Caenorhabditis elegans by a Diet Lacking Coenzyme Q

2002 • 247 citations

Selection for Delayed Senescence in Drosophila melanogaster

1984 • 239 citations

Mitochondrial superoxide and hydrogen peroxide generation, protein oxidative damage, and longevity in different species of flies

1995 • 234 citations

Comparison of mitochondrial pro-oxidant generation and anti-oxidant defenses between rat and pigeon: possible basis of variation in longevity and metabolic potential

1993 • 234 citations

Age-specific inbreeding depression and components of genetic variance in relation to the evolution of senescence.

1996 • 219 citations

Comparative biology of aging in birds: an update

2001 • 211 citations

Another set of responses and correlated responses to selection on age at reproduction in Drosophila melanogaster

1999 • 209 citations

Modulation of Life-span by Histone Deacetylase Genes inSaccharomyces cerevisiae

1999 • 206 citations

Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies

2003 • 205 citations

Role of Free Radicals in Mutation, Cancer, Aging, and the Maintenance of Life

1962 • 204 citations

Altered Quinone Biosynthesis in the Long-lived clk-1Mutants of Caenorhabditis elegans

2001 • 199 citations

Dopa decarboxylase (Ddc) affects variation in Drosophila longevity

2003 • 193 citations

Divergent roles of RAS1 and RAS2 in yeast longevity

1994 • 191 citations

Effects of Overexpression of Copper-Zinc and Manganese Superoxide Dismutases, Catalase, and Thioredoxin Reductase Genes on Longevity in Drosophila melanogaster

2003 • 186 citations

Heat-Induced Longevity Extension in Drosophila. I. Heat Treatment, Mortality, and Thermotolerance

1997 • 177 citations

MULTIPLE GENETIC MECHANISMS FOR THE EVOLUTION OF SENESCENCE INDROSOPHILA MELANOGASTER

1988 • 172 citations

Selection for starvation resistance in Drosophila melanogaster : physiological correlates, enzyme activities and multiple stress responses

1999 • 171 citations

Muscle-specific expression of Drosophila hsp70 in response to aging and oxidative stress.

1995 • 171 citations

Evolutionary genetics: From molecules to morphology

2000 • 166 citations

Age-specific mortality and reproduction respond to adult dietary restriction in Drosophila melanogaster

2001 • 159 citations

Fruit flies with additional expression of the elongation factor EF-1 alpha live longer.

1989 • 159 citations

A test of evolutionary theories of aging

2002 • 157 citations

Genetics of Aging in the Fruit Fly,Drosophila melanogaster

2003 • 149 citations

Generation of superoxide anion by mitochondria and impairment of their functions during anoxia and reoxygenation in vitro

1998 • 145 citations

Elevated paraquat resistance can be used as a bioassay for longevity in a genetically based long‐lived strain of Drosophila

1991 • 142 citations

Testing an ‘aging gene’ in long‐lived Drosophila strains: increased longevity depends on sex and genetic background

2003 • 140 citations

A Coordinate Upregulation of Antioxidant Gene Activities Is Associated With the Delayed Onset of Senescence in a Long-Lived Strain of Drosophila

1995 • 140 citations

Aging, cytochrome oxidase activity, and hydrogen peroxide release by mitochondria

1993 • 138 citations

Does Increased Mortality Favor the Evolution of More Rapid Senescence?

1993 • 135 citations

Forward and reverse selection for longevity in Drosophila is characterized by alteration of antioxidant gene expression and oxidative damage patterns☆

2000 • 133 citations

The Evolution of Avian Senescence Patterns: Implications for Understanding Primary Aging Processes

1995 • 132 citations

Direct and Correlated Responses to Selection on Age at Reproduction in Drosophila melanogaster

1992 • 130 citations

Decreased expression of Cu–Zn superoxide dismutase 1 in ants with extreme lifespan

2004 • 128 citations

Rat peptide methionine sulphoxide reductase: cloning of the cDNA, and down-regulation of gene expression and enzyme activity during aging

2001 • 127 citations

Senescence in Natural Populations of Mammals: A Comparative Study

1991 • 124 citations

Mutations in signal transduction proteins increase stress resistance and longevity in yeast, nematodes, fruit flies, and mammalian neuronal cells

1999 • 123 citations

Mitochondrial DNA remains intact during Drosophila aging, but the levels of mitochondrial transcripts are significantly reduced.

1993 • 121 citations

Aging-Specific Expression ofDrosophila hsp22

1999 • 116 citations

THE EVOLUTIONARY GENETICS OF MALE LIFE-HISTORY CHARACTERS INDROSOPHILA MELANOGASTER

1995 • 112 citations

Oxidative biochemical markers; clues to understanding aging in long-lived species

2001 • 107 citations

Evolutionary theories of ageing applied to long-lived organisms

2001 • 100 citations

Functional characterization and immunolocalization of the transporter encoded by the life-extending gene Indy

2002 • 93 citations

Adaptive evolution of a candidate gene for aging inDrosophila

2000 • 90 citations

Effects of simultaneous over-expression of Cu/ZnSOD and MnSOD on Drosophila melanogaster life span

2004 • 90 citations

Comparative biochemical and stress analysis of genetically selected drosophila strains with different longevities

1995 • 88 citations

Quantitative genetic tests of recent senescence theory: age-specific mortality and male fertility in Drosophila melanogaster

2003 • 83 citations

EVOLUTIONARY EFFECTS OF SELECTION ON AGE AT REPRODUCTION IN LARVAL AND ADULT: DROSOPHILA MELANOGASTER

1993 • 81 citations

Antioxidant status and stress resistance in long- and short-lived lines of Drosophila melanogaster

2001 • 78 citations

Multiple Genetic Mechanisms for the Evolution of Senescence in Drosophila melanogaster

1988 • 73 citations

The inbreeding decline and average dominance of genes affecting male life-history characters inDrosophila melanogaster

1995 • 68 citations

Prolongation of the Life of Drosophila subobscura by a Brief Exposure of Adults to a High Temperature

1958 • 68 citations

Structural and Functional Characteristics of Two Sodium-coupled Dicarboxylate Transporters (ceNaDC1 and ceNaDC2) fromCaenorhabditis elegans and Their Relevance to Life Span

2003 • 63 citations

The aging effect on male mating activity inDrosophila melanogaster

1985 • 62 citations

Prolongation of the yeast life span by the v‐Ha‐RAS oncogene

1990 • 56 citations

The Molecular Genetics of Aging

2000 • 56 citations

Identical longevity phenotypes are characterized by different patterns of gene expression and oxidative damage☆

2000 • 50 citations

The senescence ofDaphniafrom risky and safe habitats

2001 • 50 citations

Postponed aging and desiccation resistance in Drosophila melanogaster

2000 • 49 citations

Evolutionary Effects of Selection on Age at Reproduction in Larval and Adult Drosophila melanogaster

1993 • 46 citations

Selection for Longevity Confers Resistance to Low-Temperature Stress in Drosophila melanogaster

1998 • 44 citations

Nematode ageing: Putting metabolic theories to the test

1999 • 42 citations

Factors contributing to the plasticity of the extended longevity phenotypes of Drosophila

1996 • 39 citations

The Evolutionary Genetics of Male Life-History Characters in Drosophila melanogaster

1995 • 35 citations

A homologue of elongation factor 1γ regulates methionine sulfoxide reductase A gene expression in Saccharomyces cerevisiae

2003 • 30 citations

Changes in the respiratory chain complexes activities and in the mitochondrial DNA content during ageing in D. subobscura

1995 • 29 citations

Selection for Longevity Favors Stringent Metabolic Control in Drosophila melanogaster

1996 • 28 citations

Drosophila selected for extended longevity are more sensitive to heat shock

1999 • 26 citations

A Test of Evolutionary Theories of Senescence

2002 • 21 citations

Genetic variability in mating activity ofDrosophila melanogaster males

1983 • 9 citations

Ageing

2002 • 6 citations

University of Florida Book of Insect Records

2000 • 5 citations