Age-Related Increase of Brain Cyclooxygenase Activity and Dietary Modulation of Oxidative Status

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

1991 • 1,814 citations

The eicosanoids and their biochemical mechanisms of action

1989 • 882 citations

Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease

1993 • 832 citations

Cyclo-Oxygenase-2 Gene Expression in Neurons Contributes to Ischemic Brain Damage

1997 • 728 citations

Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines.

1993 • 710 citations

Prostaglandin endoperoxide synthase: regulation of enzyme expression

1991 • 642 citations

Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence.

1988 • 604 citations

Nutritional Influences on Aging of Fischer 344 Rats: I. Physical, Metabolic, and Longevity Characteristics

1985 • 587 citations

Evidence for a peroxide-initiated free radical mechanism of prostaglandin biosynthesis.

1980 • 481 citations

Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by interleukin-1, tumor necrosis factor-alpha, and lipopolysaccharide.

1995 • 477 citations

Cloning Two Isoforms of Rat Cyclooxygenase: Differential Regulation of Their Expression

1993 • 457 citations

Aging and oxidative stress: Modulation by dietary restriction

1996 • 450 citations

Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase).

1988 • 431 citations

Peroxynitrite, the coupling product of nitric oxide and superoxide, activates prostaglandin biosynthesis

1996 • 428 citations

3,3′,5,5′-Tetramethylbenzidine as an Ames Test Negative Chromogen for Horse-Radish Peroxidase in Enzyme-Immunoassay

1981 • 400 citations

Interleukin-6 and aging: blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction.

1993 • 322 citations

Interaction between inducible nitric oxide synthase and cyclooxygenase-2 after cerebral ischemia

1998 • 298 citations

Demonstration of an inducible cyclooxygenase in human endothelial cells using antibodies raised against the carboxyl-terminal region of the cyclooxygenase-2.

1993 • 293 citations

Influences of Dietary Restriction and Age on Liver Enzyme Activities and Lipid Peroxidation in Mice

1987 • 280 citations

Comparison of Hydroperoxide Initiator Requirements for the Cyclooxygenase Activities of Prostaglandin H Synthase-1 and −2

1995 • 219 citations

Increased Expression of Cyclooxygenases and Peroxisome Proliferator-Activated Receptor-γ in Alzheimer's Disease Brains

1999 • 205 citations

Maturational Regulation and Regional Induction of Cyclooxygenase-2 in Rat Brain: Implications for Alzheimer's Disease

1997 • 175 citations

Cyclooxygenase and inflammation in Alzheimer's disease: Experimental approaches and clinical interventions

1998 • 167 citations

Age-associated increase in PGE₂ synthesis and COX activity in murine macrophages is reversed by vitamin E

1998 • 158 citations

Interaction between peroxidase and cyclooxygenase activities in prostaglandin-endoperoxide synthase. Interpretation of reaction kinetics.

1994 • 122 citations

Production of reactive oxygen by mitochondria from normoxic and hypoxic rat heart tissue

1992 • 107 citations

Hyperadrenocorticism, Attenuated Inflammation, and the Life-Prolonging Action of Food Restriction in Mice

1995 • 105 citations

Effect of Diet Restriction on Some Biochemical Parameters Related to Aging in Mice

1983 • 94 citations

Modulation of free radicals and superoxide dismutases by age and dietary restriction

1990 • 90 citations

Effects of Calorie Restriction on Transforming Growth Factor β1 and Proinflammatory Cytokines in Murine Sjogren's Syndrome

1995 • 64 citations

Possible background mechanisms of the effectiveness of cyclooxygenase-2 inhibitors in the treatment of rheumatoid arthritis

1998 • 37 citations

Superoxide anion impairs Ca²⁺mobilization in cultured human nasal epithelial cells

1999 • 3 citations

Deleted Work

1955 • 0 citations