Membrane and Receptor Modifications of Oxidative Stress Vulnerability in Aging: Nutritional Considerations

The Cholinergic Hypothesis of Geriatric Memory Dysfunction

1982 • 5,422 citations

Cellular defenses against damage from reactive oxygen species

1994 • 2,393 citations

An application of prefrontal cortex function theory to cognitive aging.

1996 • 1,933 citations

Free Radicals and Antioxidants: A Personal View

2009 • 1,095 citations

Ginkgo Biloba

1996 • 622 citations

Ginkgo biloba

1992 • 451 citations

Distribution of m1-m4 muscarinic receptor proteins in the rat striatum: light and electron microscopic immunocytochemistry using subtype- specific antibodies

1994 • 390 citations

An introduction to the free radical hypothesis in Parkinson's disease

1992 • 385 citations

Inhibition of proteolysis protects hippocampal neurons from ischemia.

1991 • 363 citations

Acetylcholine, Aging, and Alzheimer's Disease

1997 • 355 citations

Ginkgo biloba for cerebral insufficiency.

1992 • 342 citations

Formation of peroxides in amino acids and proteins exposed to oxygen free radicals

1993 • 301 citations

Oxygen free radicals and Parkinson's disease

1991 • 293 citations

Patterns of Motor Impairment in Normal Aging, Mild Cognitive Decline, and Early Alzheimer' Disease

1997 • 277 citations

Central auditory aging: GABA changes in the inferior colliculus

1995 • 272 citations

Advanced glycation endproducts in ageing and Alzheimer's disease

1997 • 267 citations

Free radical oxidation of brain proteins in accelerated senescence and its modulation by N -tert-butyl-α-phenylnitrone

1997 • 234 citations

Myricetin and quercetin, the flavonoid constituents ofGinkgo biloba extract, greatly reduce oxidative metabolism in both resting and Ca2+-loaded brain neurons

1994 • 213 citations

Age-related Changes in the Nigrostriatum: A Behavioral and Biochemical Analysis

1978 • 197 citations

Identification of Catechol‐Protein Conjugates in Neostriatal Slices Incubated with [³H]Dopamine: Impact of Ascorbic Acid and Glutathione

1994 • 165 citations

Secondary mechanisms in neuronal trauma

1994 • 161 citations

A double-blind, placebo controlled study of Ginkgo biloba extract (‘Tanakan’) in elderly outpatients with mild to moderate memory impairment

1991 • 146 citations

Aging, Metabolism, and Alzheimer Disease: Review and Hypotheses

1997 • 146 citations

Lipid peroxidation contributes to age-related membrane rigidity

1995 • 138 citations

Mitochondrial Impairment Reduces the Threshold for in Vivo NMDA-Mediated Neuronal Death in the Striatum

1993 • 110 citations

Oxidative stress in Parkinson's disease and other neurodegenerative disorders.

1996 • 107 citations

Calcium binding to the cytosol and calcium extrusion mechanisms in intact synaptosomes and their alterations with aging.

1992 • 102 citations

Age‐Related Regional Changes in Hydroxyl Radical Stress and Antioxidants in Gerbil Brain

1993 • 93 citations

Glutathione status and reactive oxygen generation in tissues of young and old exercised rats

1997 • 80 citations

Aging‐ and Oxygen‐induced Modifications in Brain Biochemistry and Behavior^a

1994 • 79 citations

The Glucocorticoid Hypothesis of Age‐Related Hippocampal Neurodegeneration: Role of Dysregulated Intraneuronal Calcium

1994 • 77 citations

Age-related decrements in the muscarinic enhancement of K+-evoked release of endogenous striatal dopamine: an indicator of altered cholinergic-dopaminergic reciprocal inhibitory control in senescence

1988 • 74 citations

Age differences in sensitivity to H2O2- or no-induced reductions in K+-evoked dopamine release from superfused striatal slices: Reversals by PBN or Trolox

1996 • 72 citations

bcl-2 protein expression in aged brain and neurodegenerative diseases

1994 • 71 citations

Prehistoric Irrigation Systems in the Salt River Valley, Arizona

1981 • 71 citations

Age-related changes in expression of ampa-selective glutamate receptor subunits: Is calcium-permeability altered in hippocampal neurons?

1994 • 69 citations

Effects of aging on the content, composition and synthesis of sphingomyelin in the central nervous system

1992 • 68 citations

Effect of long-term treatment with EGb 761 on age-dependent structural changes in the hippocampi of three inbred mouse strains

1994 • 64 citations

Diminished Beta-Adrenergic Modulation of Cardiovascular Function in Advanced Age

1986 • 62 citations

Apoptosis and Oxidative Stress in the Aging Brain

1996 • 60 citations

Alterations in muscarinic control of striatal dopamine autoreceptors in senescence: a deficit at the ligand-muscarinic receptor interface?

1988 • 60 citations

Role of cyclic AMP-dependent protein kinase in the diminished beta adrenergic responsiveness of vascular smooth muscle with increasing age.

1989 • 59 citations

Glutamate-Mediated Excitotoxic Death of Cultured Striatal Neurons Is Mediated by Non-NMDA Receptors

1995 • 52 citations

Neuroprotective Effect of Somatostatin on Nonapoptotic NMDA‐Induced Neuronal Death: Role of Cyclic GMP

1997 • 50 citations

Decrement of muscarinic receptor-stimulated low-KMGTPase in striatum and hippocampus from the aged rat

1992 • 50 citations

Oxidant Injury in PC12 Cells—A Possible Model of Calcium “Dysregulation” in Aging: I. Selectivity of Protection Against Oxidative Stress

1997 • 44 citations

Improving Effects of FG-7080, a Serotonin Reuptake Inhibitor, on Scopolamine-Induced Performance Deficits of Memory Tasks in Rats

1993 • 41 citations

Calcium homeostasis, free radical formation, and trophic factor dependence mechanisms in Parkinson's disease.

1994 • 38 citations

Effects of Extracellular ATP on Fe²⁺‐Induced Cytotoxicity in PC‐12 Cells

1994 • 34 citations

Reductions of 56 Fe Heavy-Particle Irradiation-Induced Deficits in Striatal Muscarinic Receptor Sensitivity by Selective Cross-Activation/Inhibition of Second-Messenger Systems

1994 • 31 citations

Iminodipeptides Containing Proline with C-Terminal and N-Terminal Residues Prime the Stimulation of Human Neutrophil Superoxide Generation by fMLP

1994 • 31 citations

Comparison of Age-Related Changes in Prostaglandin E1 and Beta-Adrenergic Responsiveness of Vascular Smooth Muscle in Adult Males

1989 • 29 citations

Differentiating dopamine D2 ligands by their sensitivities to modification of the cysteine exposed in the binding-site crevice.

1996 • 28 citations

Effects of hypothalamic peptides on the aging brain

1992 • 25 citations

Iron- and peroxide-dependent conjugation of dopamine with cysteine: oxidative routes to the novel brain metabolite 5-S-cysteinyldopamine

1995 • 21 citations

Receptor- and Age-Selective Effects of Dopamine Oxidation on Receptor–G Protein Interactions in the Striatum

1998 • 20 citations

7 Hormonal Regulation of Motor Behavior in Senescence

1993 • 20 citations

The effects of chronic treatment with N-tert-butyl-α-phenylnitrone on cerebellar noradrenergic receptor function in aged F344 rats

1994 • 19 citations

Effects of stimulation of alpha 1 -adrenergic and NMDA/glycine-B receptors on learning defects in aged rats

1997 • 18 citations

Age-related alterations by chronic intermittent hypoxia on cerebral synaptosomal ATPase activities

1994 • 16 citations

Aging does not alter muscarinic receptor-mediated inhibition of cyclic AMP formation in the striatum and hippocampus

1990 • 15 citations

Age-related Changes in Cerebellar Noradrenergic Function

1988 • 14 citations

Neuroscience and neurorehabilitation Commentary

1994 • 9 citations