Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compounds

Cellular defenses against damage from reactive oxygen species

1994 • 2,393 citations

An application of prefrontal cortex function theory to cognitive aging.

1996 • 1,933 citations

Total Antioxidant Capacity of Fruits

1996 • 1,725 citations

Antioxidant Capacity of Tea and Common Vegetables

1996 • 1,332 citations

Antioxidant Capacity As Influenced by Total Phenolic and Anthocyanin Content, Maturity, and Variety ofVacciniumSpecies

1998 • 1,304 citations

The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases

1995 • 1,290 citations

Reversals of Age-Related Declines in Neuronal Signal Transduction, Cognitive, and Motor Behavioral Deficits with Blueberry, Spinach, or Strawberry Dietary Supplementation

1999 • 983 citations

Antioxidants, Oxidative Stress, and Degenerative Neurological Disorders

1999 • 828 citations

Essential fatty acids and the brain: possible health implications

2000 • 510 citations

Estradiol Enhances Learning and Memory in a Spatial Memory Task and Effects Levels of Monoaminergic Neurotransmitters

1998 • 441 citations

A possible emerging role of phytochemicals in improving age-related neurological dysfunctions: a multiplicity of effects

2001 • 438 citations

Long-Term Dietary Strawberry, Spinach, or Vitamin E Supplementation Retards the Onset of Age-Related Neuronal Signal-Transduction and Cognitive Behavioral Deficits

1998 • 434 citations

Cardiovascular Disease, Interleukin-6, and Risk of Mortality in Older Women

2001 • 431 citations

An introduction to the free radical hypothesis in Parkinson's disease

1992 • 385 citations

Blueberry Supplementation Enhances Signaling and Prevents Behavioral Deficits in an Alzheimer Disease Model

2003 • 367 citations

Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer's disease

1998 • 341 citations

Pathobiology of the Aging Rat

1993 • 252 citations

Age-Related Activation of Microglia and Astrocytes: In Vitro Studies Show Persistent Phenotypes of Aging, Increased Proliferation, and Resistance to Down-Regulation

1998 • 246 citations

Neurobehavioral aspects of antioxidants in aging

2000 • 235 citations

Dissociation of Hippocampal and Striatal Contributions to Spatial Navigation in the Water Maze

1996 • 223 citations

Calorie restriction inhibits the age-related dysregulation of the cytokines TNF-α and IL-6 in C3B10RF1 mice

1997 • 221 citations

Copernicus revisited: amyloid beta in Alzheimer's disease

2001 • 203 citations

Grape seed proanthocyanidin reduces cardiomyocyte apoptosis by inhibiting ischemia/reperfusion-induced activation of JNK-1 and C-JUN

2001 • 201 citations

Age-related Changes in the Nigrostriatum: A Behavioral and Biochemical Analysis

1978 • 197 citations

Psychomotor and spatial memory performance in aging male Fischer 344 rats

1998 • 156 citations

Spatial Learning and Memory Deficits Induced by Exposure to Iron-56-Particle Radiation

2000 • 153 citations

The effects of a novel NSAID on chronic neuroinflammation are age dependent☆

1999 • 148 citations

Short-Term Dietary Supplementation of Blueberry Polyphenolics: Beneficial Effects on Aging Brain Performance and Peripheral Tissue Function

2000 • 146 citations

Cytokine production in the central nervous system

1995 • 142 citations

Protein kinases: which one is the memory molecule?

1999 • 141 citations

Cytokine-induced expression of vascular cell adhesion molecule-1 (VCAM-1) by astrocytes and astrocytoma cell lines.

1995 • 140 citations

Psychomotor performance in the senescent rodent: reduction of deficits via striatal dopamine receptor up-regulation

1983 • 135 citations

Age-related hippocampal changes in Bcl-2:Bax ratio, oxidative stress, redox-active iron and apoptosis associated with aluminum-induced neurodegeneration: increased susceptibility with aging.

1999 • 131 citations

Effect of age on the radial arm water maze—a test of spatial learning and memory

2003 • 126 citations

Behavioral and ultrastructural changes induced by chronic neuroinflammation in young rats

2000 • 111 citations

Motor learning deficits in aged rats are correlated with loss of cerebellar noradrenergic function

1993 • 109 citations

Delphinidin inhibits endothelial cell proliferation and cell cycle progression through a transient activation of ERK-1/-2

2003 • 96 citations

BCL-2 family members in the development and degenerative pathologies of the nervous system

1998 • 93 citations

Drugs to Treat Age‐Related Neurodegenerative Problems The Final Frontier of Medical Science?

1990 • 88 citations

Interleukin-1 Enhances the ATP-Evoked Release of Arachidonic Acid from Mouse Astrocytes

1997 • 86 citations

Brain dysfunction associated with an induction of nitric oxide synthase following an intracerebral injection of lipopolysaccharide in rats

1999 • 83 citations

AGE-RELATED NEURODEGENERATION AND OXIDATIVE STRESS

1998 • 80 citations

Aging‐ and Oxygen‐induced Modifications in Brain Biochemistry and Behavior^a

1994 • 79 citations

Flavonoid Phytochemicals Regulate Activator Protein-1 Signal Transduction Pathways in Endometrial and Kidney Stable Cell Lines

2002 • 78 citations

Peripheral administration of novel anti-inflammatories can attenuate the effects of chronic inflammation within the CNS

1999 • 78 citations

The Glucocorticoid Hypothesis of Age‐Related Hippocampal Neurodegeneration: Role of Dysregulated Intraneuronal Calcium

1994 • 77 citations

The effects of aging and oxidative stress on psychomotor and cognitive behavior

1999 • 76 citations

CNS-induced deficits of heavy particle irradiation in space: The aging connection

2000 • 67 citations

Membrane and Receptor Modifications of Oxidative Stress Vulnerability in Aging: Nutritional Considerations

1998 • 63 citations

Neurons reduce glial responses to lipopolysaccharide (LPS) and prevent injury of microglial cells from over‐activation by LPS

2001 • 63 citations

The putative role of free radicals in the loss of neuronal functioning in senescence

1992 • 59 citations

Selective cross-activation/inhibition of second messenger systems and the reduction of age-related deficits in the muscarinic control of dopamine release from perifused rat striata

1990 • 58 citations

CNS effects of heavy particle irradiation in space: Behavioral implications

1998 • 55 citations

Magnetic resonance microscopy of iron in the basal forebrain cholinergic structures of the aged mouse lemur

1999 • 44 citations

Effects of Bifemelane on Muscarinic Receptors and Choline Acetyltransferase in the Brains of Aged Rats Following Chronic Cerebral Hypoperfusion Induced by Permanent Occlusion of Bilateral Carotid Arteries

1996 • 35 citations

The Relationship of Aging to Endotoxin Shock and to Production of TNF-

1996 • 35 citations

Differential Effect of Aging on Cholesterol Modulation of Carbachol-Stimulated Low-Km GTPase in Striatal Synaptosomes

1998 • 32 citations

Dopamine Modulation of Responses Mediated by Excitatory Amino Acids in the Neostriatum

1997 • 32 citations

Characterization of [3H]pentazocine binding sites in post-mortem human frontal cortex

1996 • 31 citations

Age-related deficits in the cerebellar beta adrenergic signal transduction cascade in Fischer 344 rats.

1997 • 31 citations

Primary Cultures of Rat Cerebellar Granule Cells as a Model to Study Neuronal 5‐Lipoxygenase and FLAP Gene Expression

1999 • 26 citations