The effects of a novel NSAID on chronic neuroinflammation are age dependent☆

Developments of a water-maze procedure for studying spatial learning in the rat

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Place navigation impaired in rats with hippocampal lesions

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Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.

1989 • 1,752 citations

Life and Death of Neurons in the Aging Brain

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The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases

1995 • 1,290 citations

Risk of Alzheimer's disease and duration of NSAID use

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Clinical trial of indomethacin in Alzheimer's disease

1993 • 996 citations

Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease

1993 • 832 citations

Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR

1987 • 806 citations

Complement activation by beta-amyloid in Alzheimer disease.

1992 • 804 citations

Inverse association of anti‐inflammatory treatments and Alzheimer's disease

1994 • 567 citations

Interleukin-1 Expression in Different Plaque Types in Alzheimerʼs Disease

1995 • 538 citations

Inflammation and Alzheimer's disease pathogenesis

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Nonsteroidal anti-inflammatory drugs in Alzheimer's disease

1995 • 442 citations

Glial cytokines in Alzheimer's disease: Review and pathogenic implications

1995 • 412 citations

Activation of the classical complement pathway in brain tissue of Alzheimer patients

1989 • 385 citations

Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer's disease

1998 • 341 citations

Novel nonsterodial anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat

1994 • 293 citations

Inflammatory mechanisms in Alzheimer's disease

1994 • 285 citations

Do nonsteroidal anti-inflammatory drugs decrease the risk for Alzheimer's disease?

1995 • 284 citations

THE ASSOCIATION BETWEEN HEAD TRAUMA AND ALZHEIMER'S DISEASE

1990 • 251 citations

Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging

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Age-Related Activation of Microglia and Astrocytes: In Vitro Studies Show Persistent Phenotypes of Aging, Increased Proliferation, and Resistance to Down-Regulation

1998 • 246 citations

Brain Endothelial Cells Express Cyclooxygenase-2 during Lipopolysaccharide-Induced Fever: Light and Electron Microscopic Immunocytochemical Studies

1998 • 245 citations

Microglial Expression of MHC Class II Increases in Normal Aging of Nonhuman Primates

1998 • 228 citations

Enlarged and phagocytic, but not primed, interleukin-1α-immunoreactive microglia increase with age in normal human brain

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Endothelium-derived relaxing factor (nitric oxide) has protective actions in the stomach

1989 • 219 citations

Correlation of Astrocytic S100β Expression with Dystrophic Neurites in Amyloid Plaques of Alzheimerʼs Disease

1996 • 210 citations

Molecular, cellular, and pathologic characterization of HLA-DR immunoreactivity in normal elderly and Alzheimer's disease brain

1990 • 194 citations

S100β expression in Alzheimer's disease: Relation to neuropathology in brain regions

1994 • 193 citations

Microglial inter leukin‐1α expression in brain regions in Alzheimer's disease: correlation with neuritic plaque distribution

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Abnormalities of neural circuitry in Alzheimer's disease

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Brain interleukin-1 beta in Alzheimer's disease and vascular dementia.

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Effects of ageing on microglia in the normal rat brain: immunohistochemical observations

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Reactive microglia express class I and class II major histocompatibility complex antigens in Alzheimer's disease

1990 • 174 citations

Electrophysiological behavior of microglia

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Cyclooxygenase and inflammation in Alzheimer's disease: Experimental approaches and clinical interventions

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Microglial Cell Activation in Aging and Alzheimer Disease

1997 • 157 citations

Life-long overexpression of S100β in Down’s syndrome: implications for Alzheimer pathogenesis

1998 • 131 citations

Cholinergic activity and amyloid precursor protein metabolism

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Distribution of interleukin‐1‐immunoreactive microglia in cerebral cortical layers: implications for neuritic plaque formation in Alzheimer’s disease

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Prevalence of Dementia amongst Elderly Japanese with Leprosy: Apparent Effect of Chronic Drug Therapy

1992 • 111 citations

Brain inflammatory response induced by intracerebroventricular infusion of lipopolysaccharide: an immunohistochemical study

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Effect of endothelium-derived relaxing factor on the gastric lesion induced by HCl in rats.

1990 • 109 citations

Lipopolysaccharide Injected into the Cerebral Ventricle Evokes Fever through Induction of Cyclooxygenase-2 in Brain Endothelial Cells

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A case‐control study of Alzheimer's disease in China

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Aging and atropine effects on spatial navigation in the Morris water task.

1988 • 102 citations

β-Amyloid converts an acute phase injury response to chronic injury responses

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Cytokines in Alzheimer's disease

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Aging and atropine effects on spatial navigation in the Morris water task.

1988 • 82 citations

Human astrocyte production of tumour necrosis factor-α, interleukin-1β, and interleukin-6 following exposure to lipopolysaccharide endotoxin

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Peripheral administration of novel anti-inflammatories can attenuate the effects of chronic inflammation within the CNS

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Nonsteroidal antiinflammatory drug use in Alzheimer's disease

1994 • 76 citations

Neurotoxic consequences of central long-term administration of interleukin-2 in rats

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Elevated interleukin-6 secretion levels by mononuclear cells of Alzheimer's patients

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Morphology and Neurochemical Characteristics of the Vulnerable Neurons in Brain Aging and Alzheimer’s Disease

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Responses in the aged rat brain after total immunolesion

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Pathological correlates of dementia in Alzheimer's disease

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Effects of flurbiprofen and flurbinitroxybutylester on prostaglandin endoperoxide synthases

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New insights into the neuropathology and cell biology of Alzheimer's disease.

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Pathological and Biochemical Studies of Chronic Neuroinflammation May Lead to Therapies for Alzheimer’s Disease

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Neuro-immune interactions

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Inflammatory Mechanisms of Alzheimer's Disease: Basic Research, Clinical Studies, and Future Directions

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