Enhanced Phagocytosis through Inhibition of de Novo Ceramide Synthesis

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

1986 • 1,150 citations

Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.

1986 • 999 citations

Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

1995 • 835 citations

Sphingolipid metabolism and cell growth regulation

1996 • 709 citations

The molecular dissection of Fc gamma receptor mediated phagocytosis

1995 • 309 citations

Function and heterogeneity of human Fc receptors for immunoglobulin G.

1989 • 251 citations

Tyrosine phosphorylation of the gamma subunit of Fc gamma receptors, p72syk, and paxillin during Fc receptor-mediated phagocytosis in macrophages.

1994 • 244 citations

Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway.

1990 • 230 citations

Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase.

1993 • 198 citations

Cell-permeable ceramides inhibit the stimulation of DNA synthesis and phospholipase D activity by phosphatidate and lysophosphatidate in rat fibroblasts.

1994 • 188 citations

Signaling properties of CR3 (CD11b/CD18) and CR1 (CD35) in relation to phagocytosis of complement-opsonized particles.

1993 • 166 citations

Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation

1992 • 154 citations

Effect of harvesting methods, growth conditions and growth phase on diacylglycerol levels in cultured human adherent cells

1988 • 153 citations

Human Fc gamma RII, in the absence of other Fc gamma receptors, mediates a phagocytic signal.

1991 • 140 citations

Involvement of p72syk, a protein-tyrosine kinase, in Fc gamma receptor signaling

1993 • 137 citations

Quantitative Measurement of Sphingosine 1-Phosphate in Biological Samples by Acylation with Radioactive Acetic Anhydride

1995 • 118 citations

Complement receptor-mediated phagocytosis is associated with accumulation of phosphatidylcholine-derived diglyceride in human neutrophils. Involvement of phospholipase D and direct evidence for a positive feedback signal of protein kinase.

1992 • 115 citations

Inhibition of Sphingolipid Synthesis by Cycloserine In Vitro and In Vivo

1984 • 110 citations

Abrogation of the Fc gamma receptor IIA-mediated phagocytic signal by stem-loop Syk antisense oligonucleotides.

1996 • 108 citations

The Fc Receptor for Immunoglobulin G (FcγRII) on Human Platelets

1995 • 108 citations

Induction of phagocytosis by a protein tyrosine kinase

1995 • 106 citations

Role of phospholipase D-derived diradylglycerol in the activation of the human neutrophil respiratory burst oxidase. Inhibition by phosphatidic acid phosphohydrolase inhibitors.

1992 • 105 citations

Syk Tyrosine Kinase Is Required for Immunoreceptor Tyrosine Activation Motif-dependent Actin Assembly

1996 • 100 citations

A Novel Enzyme That Catalyzes the Esterification of -Acetylsphingosine

1996 • 94 citations

Fumonisin Toxicity and Sphingolipid Biosynthesis

1996 • 91 citations

Inhibition of phosphatidic acid phosphohydrolase activity by sphingosine

1990 • 87 citations

Inhibition of serine palmitoyltransferase in vitro and long-chain base biosynthesis in intact Chinese hamster ovary cells by .beta.-chloroalanine

1988 • 78 citations

Ceramide regulates oxidant release in adherent human neutrophils

1994 • 77 citations

Characterization of the Fcγ receptor on human platelets

1990 • 68 citations

The high affinity Fc gamma receptor (CD64) induces phagocytosis in the absence of its cytoplasmic domain: the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI.

1994 • 64 citations

Phospholipase D-mediated diradylglycerol formation coincides with H2O2 and lactoferrin release in adherent human neutrophils.

1994 • 60 citations

Ceramide Inhibits IgG-Dependent Phagocytosis in Human Polymorphonuclear Leukocytes

1997 • 59 citations

Mitogen-activated protein kinase activation during IgG-dependent phagocytosis in human neutrophils: inhibition by ceramide.

1997 • 56 citations

Determinants of the phagocytic signal mediated by the type IIIA Fc gamma receptor, Fc gamma RIIIA: sequence requirements and interaction with protein-tyrosine kinases.

1995 • 47 citations

Structure/function relationships of Fcγ receptors in phagocytosis

1995 • 46 citations

Metabolic effects of short‐chain ceramide and glucosylceramide on sphingolipids and protein kinase C

1992 • 45 citations

Diversity in phagocytic signalling

2001 • 39 citations

Activation of a Plasma Membrane–Associated Neutral Sphingomyelinase and Concomitant Ceramide Accumulation During IgG-Dependent Phagocytosis in Human Polymorphonuclear Leukocytes

1998 • 33 citations

Source and role of diacylglycerol formed during phagocytosis of opsonized yeast particles and associated respiratory burst in human neutrophils

1991 • 33 citations

Activation of a Plasma Membrane–Associated Neutral Sphingomyelinase and Concomitant Ceramide Accumulation During IgG-Dependent Phagocytosis in Human Polymorphonuclear Leukocytes

1998 • 32 citations

Modulation of human mononuclear phagocyte FcγRII mRNA and protein

1989 • 24 citations

Modulation of macrophage Fc gamma receptors by rGM-CSF.

1993 • 22 citations

The Fcγ Receptors on Human Macrophages

1989 • 9 citations