Roles for lipid phosphate phosphatases in regulation of cellular signaling

Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1

1998 • 1,003 citations

Lysophosphatidic Acid, a Multifunctional Phospholipid Messenger

1995 • 592 citations

Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells

1995 • 523 citations

Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1‐phosphate

1998 • 516 citations

Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets

1995 • 435 citations

Raf-1 Kinase Possesses Distinct Binding Domains for Phosphatidylserine and Phosphatidic Acid

1996 • 402 citations

Plasma membrane fractions from rat liver contain a phosphatidate phosphohydrolase distinct from that in the endoplasmic reticulum and cytosol.

1991 • 271 citations

Mammalian Lipid Phosphate Phosphohydrolases

1998 • 253 citations

Identification of a novel phosphatase sequence motif

1997 • 239 citations

The Drosophila protein Wunen repels migrating germ cells

1997 • 205 citations

Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death

2000 • 195 citations

Human Type 2 Phosphatidic Acid Phosphohydrolases

1998 • 178 citations

Phospholipase D and membrane traffic

1999 • 177 citations

Activation of actin polymerization by phosphatidic acid derived from phosphatidylcholine in IIC9 fibroblasts.

1993 • 175 citations

From phosphatases to vanadium peroxidases: A similar architecture of the active site

1997 • 165 citations

Spatially restricted activity of a Drosophila lipid phosphatase guides migrating germ cells

2001 • 161 citations

Cloning and Characterization of Two Human Isozymes of Mg2+-independent Phosphatidic Acid Phosphatase

1997 • 157 citations

Lipid phosphate phosphohydrolase-1 degrades exogenous glycerolipid and sphingolipid phosphate esters

1999 • 141 citations

Lysophosphatidic Acid-induced Mitogenesis Is Regulated by Lipid Phosphate Phosphatases and Is Edg-receptor Independent

2001 • 136 citations

An unexpected structural relationship between integral membrane phosphatases and soluble haloperoxidases

1997 • 134 citations

Isolation and Characterization of the Saccharomyces cerevisiae DPP1 Gene Encoding Diacylglycerol Pyrophosphate Phosphatase

1998 • 125 citations

Isolation and Characterization of the Saccharomyces cerevisiae LPP1 Gene Encoding a Mg2+-independent Phosphatidate Phosphatase

1998 • 121 citations

Sequential Actions of Phospholipase D and Phosphatidic Acid Phosphohydrolase 2b Generate Diglyceride in Mammalian Cells

1999 • 116 citations

Identification of structurally important domains of lipid phosphate phosphatase-1: implications for its sites of action

2000 • 110 citations

Identification and cDNA Cloning of 35-kDa Phosphatidic Acid Phosphatase (Type 2) Bound to Plasma Membranes

1996 • 109 citations

G-protein-coupled Receptor Stimulation of the p42/p44 Mitogen-activated Protein Kinase Pathway Is Attenuated by Lipid Phosphate Phosphatases 1, 1a, and 2 in Human Embryonic Kidney 293 Cells

2001 • 94 citations

Identification of a novel human phosphatidic acid phosphatase type 2 isoform

1998 • 85 citations

Purification and properties of phosphatidic acid phosphatase from porcine thymus membranes.

1992 • 82 citations

The Dri 42 Gene, Whose Expression Is Up-regulated during Epithelial Differentiation, Encodes a Novel Endoplasmic Reticulum Resident Transmembrane Protein

1996 • 71 citations

Mice mutant forPpap2c, a homolog of the germ cell migration regulator wunen, are viable and fertile

2000 • 71 citations

Purification and Characterization of a Novel Plasma Membrane Phosphatidate Phosphohydrolase from Rat Liver

1995 • 70 citations

A novel ecto-phosphatidic acid phosphohydrolase activity mediates activation of neutrophil superoxide generation by exogenous phosphatidic acid.

1993 • 58 citations

Molecular Cloning of Two Alternatively Spliced Forms of Human Phosphatidic Acid Phosphatase cDNAs that Are Differentially Expressed in Normal and Tumor Cells

1998 • 52 citations

Identification of the Phosphatidic Acid Phosphatase Type 2a Isozyme as an Androgen-regulated Gene in the Human Prostatic Adenocarcinoma Cell Line LNCaP

1998 • 48 citations

Mutagenesis of the Phosphatase Sequence Motif in Diacylglycerol Pyrophosphate Phosphatase fromSaccharomyces cerevisiae

1999 • 47 citations

Lipid Phosphate Phosphatase-1 and Ca2+ Control Lysophosphatidate Signaling through EDG-2 Receptors

2000 • 45 citations

Isolation of a cDNA Encoding Human Lysophosphatidic Acid Phosphatase That Is Involved in the Regulation of Mitochondrial Lipid Biosynthesis

1999 • 42 citations

Role of phosphatidic acid phosphatase 2a in uptake of extracellular lipid phosphate mediators

2000 • 41 citations