Expression of a Catalytically Inactive Sphingosine Kinase Mutant Blocks Agonist-induced Sphingosine Kinase Activation

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

SMART, a simple modular architecture research tool: Identification of signaling domains

1998 • 3,523 citations

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1996 • 1,493 citations

Organization and regulation of mitogen-activated protein kinase signaling pathways

1999 • 1,288 citations

Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1

1998 • 1,003 citations

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

1993 • 879 citations

Ceramide in the eukaryotic stress response

2000 • 729 citations

Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling

1994 • 726 citations

Transformation of rat cells by DNA of human adenovirus 5

1973 • 664 citations

Molecular Cloning and Functional Characterization of a Novel Mammalian Sphingosine Kinase Type 2 Isoform

2000 • 654 citations

Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth.

1996 • 567 citations

Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase

1998 • 528 citations

Sphingosine Kinase Expression Increases Intracellular Sphingosine-1-Phosphate and Promotes Cell Growth and Survival

1999 • 516 citations

Dual Actions of Sphingosine-1-Phosphate: Extracellular through the Gi-coupled Receptor Edg-1 and Intracellular to Regulate Proliferation and Survival

1998 • 468 citations

Tumor necrosis factor-α induces adhesion molecule expression through the sphingosine kinase pathway

1998 • 404 citations

Calcium mobilization via sphingosine kinase in signalling by the FcɛRI antigen receptor

1996 • 374 citations

SMART: identification and annotation of domains from signalling and extracellular protein sequences

1999 • 325 citations

Characterization of a Novel Sphingosine 1-Phosphate Receptor, Edg-8

2000 • 323 citations

Mammalian Diacylglycerol Kinases, a Family of Lipid Kinases with Signaling Functions

1999 • 284 citations

EDG1 Is a Functional Sphingosine-1-phosphate Receptor That Is Linked via a Gi/o to Multiple Signaling Pathways, Including Phospholipase C Activation, Ca2+Mobilization, Ras-Mitogen-activated Protein Kinase Activation, and Adenylate Cyclase Inhibition

1998 • 279 citations

Involvement of Sphingosine 1-Phosphate in Nerve Growth Factor-Mediated Neuronal Survival and Differentiation

1997 • 278 citations

Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway.

1994 • 273 citations

Activation of Sphingosine Kinase by Tumor Necrosis Factor-α Inhibits Apoptosis in Human Endothelial Cells

1999 • 270 citations

Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities

1989 • 259 citations

Protein kinase C regulates the nuclear localization of diacylglycerol kinase-ζ

1998 • 256 citations

Identification of cDNAs encoding two G protein‐coupled receptors for lysosphingolipids¹

1997 • 247 citations

Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors

1998 • 208 citations

Molecular Cloning of a Novel Human Diacylglycerol Kinase Highly Selective for Arachidonate-containing Substrates

1996 • 205 citations

Sphingosine‐1‐Phosphate in Cell Growth and Cell Death^a

1998 • 202 citations

Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death

2000 • 195 citations

The novel sphingosine 1-phosphate receptor AGR16 is coupled via pertussis toxin-sensitive and -insensitive G-proteins to multiple signalling pathways

1998 • 195 citations

The LCB4 (YOR171c) and LCB5(YLR260w) Genes of Saccharomyces Encode Sphingoid Long Chain Base Kinases

1998 • 184 citations

Sphingosine 1-Phosphate Rapidly Activates the Mitogen-activated Protein Kinase Pathway by a G Protein-dependent Mechanism

1995 • 180 citations

Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes

2000 • 177 citations

Sphingosine 1-phosphate: a prototype of a new class of second messengers

1999 • 176 citations

Patterns of divergence in homologous proteins as indicators of secondary and tertiary structure: A prediction of the structure of the catalytic domain of protein kinases

1991 • 173 citations

FcγRI Coupling to Phospholipase D Initiates Sphingosine Kinase-mediated Calcium Mobilization and Vesicular Trafficking

1998 • 172 citations

Molecular Cloning and Characterization of a Novel Human Diacylglycerol Kinase ζ

1996 • 167 citations

Drosophila retinal degeneration A gene encodes an eye-specific diacylglycerol kinase with cysteine-rich zinc-finger motifs and ankyrin repeats.

1993 • 155 citations

Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation

1992 • 154 citations

Tumor Necrosis Factor-α Stimulates the Maturation of Sterol Regulatory Element Binding Protein-1 in Human Hepatocytes through the Action of Neutral Sphingomyelinase

1998 • 146 citations

Subcellular localization and membrane topology of sphingosine-1-phosphate lyase in rat liver

1991 • 142 citations

Functional Roles of Sphingosine, Sphingosine 1-Phosphate, and Methylsphingosines: In Regard to Membrane Sphingolipid Signaling Pathways

1997 • 134 citations

Human sphingosine kinase: molecular cloning, functional characterization and tissue distribution

2000 • 133 citations

Divergence in Signal Transduction Pathways of Platelet-derived Growth Factor (PDGF) and Epidermal Growth Factor (EGF) Receptors

1997 • 111 citations

Functional characterization of human sphingosine kinase‐1

2000 • 103 citations

Sphingosine Is a Novel Activator of 3-Phosphoinositide-dependent Kinase 1

2000 • 102 citations

Activation of sphingosine kinase in pheochromocytoma PC12 neuronal cells in response to trophic factors

1997 • 99 citations

Formyl Peptide Receptor Signaling in HL-60 Cells through Sphingosine Kinase

1999 • 99 citations

Sphingosine 1-phosphate, a novel signaling molecule, stimulates DNA binding activity of AP-1 in quiescent Swiss 3T3 fibroblasts.

1994 • 86 citations

Protein kinase C-dependent regulation of human erythroleukemia (HEL) cell sphingosine kinase activity

1996 • 78 citations

Both p38αMAPK and JNK/SAPK Pathways Are Important for Induction of Nitric-oxide Synthase by Interleukin-1β in Rat Glomerular Mesangial Cells

1999 • 76 citations

Activation of casein kinase II by sphingosine.

1991 • 70 citations

Cell membrane signaling as target in cancer therapy. II: Inhibitory effect of N,N,N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line through blocking of tumor cell-dependent platelet aggregation.

1991 • 66 citations

Cross-talk between Phosphatidylinositol 3-Kinase and Sphingomyelinase Pathways as a Mechanism for Cell Survival/Death Decisions

2000 • 65 citations

Tumor Necrosis Factor-α Autoregulates Interleukin-6 Synthesis via Activation of Protein Kinase C

1997 • 52 citations

p85/p110-type Phosphatidylinositol Kinase Phosphorylates Not Only the D-3, but Also the D-4 Position of the Inositol Ring

1999 • 23 citations

Lipid Phosphate Phosphatase‐1 in the Regulation of Lysophosphatidate Signaling

2000 • 16 citations