Structural organization of mammalian lipid phosphate phosphatases: implications for signal transduction

Protein kinase C and lipid signaling for sustained cellular responses

1995 • 2,527 citations

Functions of Ceramide in Coordinating Cellular Responses to Stress

1996 • 1,620 citations

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

The sphingomyelin cycle and the second messenger function of ceramide.

1994 • 1,255 citations

The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling

1994 • 934 citations

Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins

1989 • 846 citations

Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex.

1996 • 727 citations

Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling

1994 • 726 citations

Lysophosphatidic Acid, a Multifunctional Phospholipid Messenger

1995 • 592 citations

Characterization of a Novel Subtype of Human G Protein-coupled Receptor for Lysophosphatidic Acid

1998 • 535 citations

Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells

1995 • 523 citations

Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1‐phosphate

1998 • 516 citations

PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid.

1995 • 506 citations

Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase.

1994 • 473 citations

Dual Actions of Sphingosine-1-Phosphate: Extracellular through the Gi-coupled Receptor Edg-1 and Intracellular to Regulate Proliferation and Survival

1998 • 468 citations

Antibody-Enhanced Infection by HIV-1 Via Fc Receptor-Mediated Entry

1988 • 462 citations

Tumor Necrosis Factor (TNF)-α Inhibits Insulin Signaling through Stimulation of the p55 TNF Receptor and Activation of Sphingomyelinase

1996 • 404 citations

Raf-1 Kinase Possesses Distinct Binding Domains for Phosphatidylserine and Phosphatidic Acid

1996 • 402 citations

Evidence that phospholipase D mediates ADP ribosylation factor-dependent formation of Golgi coated vesicles.

1996 • 380 citations

X-ray structure of a vanadium-containing enzyme: chloroperoxidase from the fungus Curvularia inaequalis.

1996 • 370 citations

Mutations in the Glucose-6-Phosphatase Gene that Cause Glycogen Storage Disease Type 1a

1993 • 367 citations

Phosphorylation of Raf by ceramide-activated protein kinase

1995 • 332 citations

New Developments in Phospholipase D

1997 • 313 citations

Phospholipase D and Its Product, Phosphatidic Acid, Mediate Agonist-dependent Raf-1 Translocation to the Plasma Membrane and the Activation of the Mitogen-activated Protein Kinase Pathway

1999 • 297 citations

Modulation of protein kinase C and diverse cell functions by sphingosine — a pharmacologically interesting compound linking sphingolipids and signal transduction

1989 • 281 citations

Implications for the Catalytic Mechanism of the Vanadium-Containing Enzyme Chloroperoxidase from the Fungus Curvularia inaequalis by X-Ray Structures of the Native and Peroxide Form

1997 • 275 citations

Plasma membrane fractions from rat liver contain a phosphatidate phosphohydrolase distinct from that in the endoplasmic reticulum and cytosol.

1991 • 271 citations

Mammalian Lipid Phosphate Phosphohydrolases

1998 • 253 citations

Sphingosine 1-phosphate signalling through the G-protein-coupled receptor Edg-1

1998 • 252 citations

Phospholipase D Stimulates Release of Nascent Secretory Vesicles from the trans-Golgi Network

1997 • 251 citations

Sphingoid base 1-phosphate phosphatase: A key regulator of sphingolipid metabolism and stress response

1998 • 244 citations

Identification of a novel phosphatase sequence motif

1997 • 239 citations

Tumor necrosis factor-alpha (TNF-alpha) signal transduction through ceramide. Dissociation of growth inhibitory effects of TNF-alpha from activation of nuclear factor-kappa B.

1993 • 217 citations

Stimulation of actin stress fibre formation mediated by activation of phospholipase D

1996 • 215 citations

The Drosophila protein Wunen repels migrating germ cells

1997 • 205 citations

Diacylglycerol and Phosphatidate Generated by Phospholipases C and D, Respectively, Have Distinct Fatty Acid Compositions and Functions

1997 • 200 citations

Phospholipase D is present on Golgi-enriched membranes and its activation by ADP ribosylation factor is sensitive to brefeldin A.

1995 • 193 citations

Human Type 2 Phosphatidic Acid Phosphohydrolases

1998 • 178 citations

Activation of actin polymerization by phosphatidic acid derived from phosphatidylcholine in IIC9 fibroblasts.

1993 • 175 citations

Molecular cloning of a high-affinity receptor for the growth factor-like lipid mediator lysophosphatidic acid from Xenopus oocytes

1996 • 173 citations

Transmembrane Topology of Glucose-6-Phosphatase

1998 • 170 citations

Ceramide 1-phosphate, a novel phospholipid in human leukemia (HL-60) cells. Synthesis via ceramide from sphingomyelin.

1990 • 165 citations

From phosphatases to vanadium peroxidases: A similar architecture of the active site

1997 • 165 citations

Recombinant Human G Protein-Coupled Lysophosphatidic Acid Receptors Mediate Intracellular Calcium Mobilization

1998 • 163 citations

Cloning and Characterization of Two Human Isozymes of Mg2+-independent Phosphatidic Acid Phosphatase

1997 • 157 citations

Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation

1992 • 154 citations

Identification and Characterization of Saccharomyces cerevisiae Dihydrosphingosine-1-phosphate Phosphatase

1997 • 154 citations

Sphingomyelinase and Ceramide Suppress Insulin-induced Tyrosine Phosphorylation of the Insulin Receptor Substrate-1

1996 • 153 citations

Lysophosphatidic acid possesses dual action in cellproliferation.

1994 • 151 citations

Short-chain ceramide-1-phosphates are novel stimulators of DNA synthesis and cell division: antagonism by cell-permeable ceramides.

1995 • 145 citations

Identification of Diacylglycerol Pyrophosphate as a Novel Metabolic Product of Phosphatidic Acid during G-protein Activation in Plants

1996 • 144 citations

Lipid phosphate phosphohydrolase-1 degrades exogenous glycerolipid and sphingolipid phosphate esters

1999 • 141 citations

Phosphatidate Phosphohydrolase Catalyzes the Hydrolysis of Ceramide 1-Phosphate, Lysophosphatidate, and Sphingosine 1-Phosphate

1996 • 141 citations

Ceramide stimulates epidermal growth factor receptor phosphorylation in A431 human epidermoid carcinoma cells. Evidence that ceramide may mediate sphingosine action

1991 • 134 citations

An unexpected structural relationship between integral membrane phosphatases and soluble haloperoxidases

1997 • 134 citations

Alpha2-adrenergic receptor-mediated release of lysophosphatidic acid by adipocytes. A paracrine signal for preadipocyte growth.

1998 • 134 citations

Isolation and Characterization of the Saccharomyces cerevisiae DPP1 Gene Encoding Diacylglycerol Pyrophosphate Phosphatase

1998 • 125 citations

Stimulation of DNA synthesis by natural ceramide 1-phosphate

1997 • 121 citations

Isolation and Characterization of the Saccharomyces cerevisiae LPP1 Gene Encoding a Mg2+-independent Phosphatidate Phosphatase

1998 • 121 citations

Phosphatidate phosphohydrolase and signal transduction

1996 • 119 citations

Effects of Cell-Permeable Ceramides and Tumor Necrosis Factor-α on Insulin Signaling and Glucose Uptake in 3T3-L1 Adipocytes

1998 • 112 citations

Identification and cDNA Cloning of 35-kDa Phosphatidic Acid Phosphatase (Type 2) Bound to Plasma Membranes

1996 • 109 citations

Mutations in the glucose-6-phosphatase gene are associated with glycogen storage disease types 1a and 1aSP but not 1b and 1c.

1995 • 108 citations

Cell-permeable Ceramides Prevent the Activation of Phospholipase D by ADP-ribosylation Factor and RhoA

1997 • 106 citations

Multiple genes for membrane-bound phosphatases in Escherichia coli and their action on phospholipid precursors

1983 • 103 citations

The Escherichia coli pgpB Gene Encodes for a Diacylglycerol Pyrophosphate Phosphatase Activity

1996 • 99 citations

Purification and Characterization of Diacylglycerol Pyrophosphate Phosphatase from Saccharomyces cerevisiae

1996 • 94 citations

Phosphatidate phosphatases and diacylglycerol pyrophosphate phosphatases in Saccharomyces cerevisiae and Escherichia coli

1997 • 87 citations

Mammalian Mg2+-independent Phosphatidate Phosphatase (PAP2) Displays Diacylglycerol Pyrophosphate Phosphatase Activity

1997 • 85 citations

Identification of a novel human phosphatidic acid phosphatase type 2 isoform

1998 • 85 citations

Purification and properties of phosphatidic acid phosphatase from porcine thymus membranes.

1992 • 82 citations

Lysophosphatidic Acid Activates NF-κB in Fibroblasts

1999 • 82 citations

Ceramide 1‐Phosphate Phosphatase Activity in Brain

1993 • 80 citations

Structure-Function Analysis of Human Glucose-6-phosphatase, the Enzyme Deficient in Glycogen Storage Disease Type 1a

1995 • 78 citations

Identity of a Conserved Motif in Phospholipid Scramblase That Is Required for Ca²⁺-Accelerated Transbilayer Movement of Membrane Phospholipids

1998 • 73 citations

Decreased activities of phosphatidate phosphohydrolase and phospholipase D in ras and tyrosine kinase (fps) transformed fibroblasts.

1993 • 71 citations

The Dri 42 Gene, Whose Expression Is Up-regulated during Epithelial Differentiation, Encodes a Novel Endoplasmic Reticulum Resident Transmembrane Protein

1996 • 71 citations

Purification and Characterization of a Novel Plasma Membrane Phosphatidate Phosphohydrolase from Rat Liver

1995 • 70 citations

A Novel Pathway for Tumor Necrosis Factor-α and Ceramide Signaling Involving Sequential Activation of Tyrosine Kinase, p21 , and Phosphatidylinositol 3-Kinase

1999 • 69 citations

Proinflammatory Macrophage-activating Properties of the Novel Phospholipid Diacylglycerol Pyrophosphate

1999 • 65 citations

Effect of tumor necrosis factor-alpha on insulin action in cultured rat skeletal muscle cells.

1996 • 62 citations

A novel ecto-phosphatidic acid phosphohydrolase activity mediates activation of neutrophil superoxide generation by exogenous phosphatidic acid.

1993 • 58 citations

Increased concentrations of phosphatidate, diacylglycerol and ceramide in ras- and tyrosine kinase (fps)-transformed fibroblasts

1997 • 58 citations

Primary Structure and Characterization of the Vanadium Chloroperoxidase from the Fungus Curvularia inaequails

1995 • 57 citations

Molecular Cloning of Two Alternatively Spliced Forms of Human Phosphatidic Acid Phosphatase cDNAs that Are Differentially Expressed in Normal and Tumor Cells

1998 • 52 citations

Diacylglycerol pyrophosphate, a novel phospholipid compound

1993 • 50 citations

Identification of the Phosphatidic Acid Phosphatase Type 2a Isozyme as an Androgen-regulated Gene in the Human Prostatic Adenocarcinoma Cell Line LNCaP

1998 • 48 citations

Role of ascorbate in the activation of NF-κB by tumour necrosis factor-α in T-cells

1997 • 47 citations

Sphingosine activates cellular diacylglycerol kinase in intact Jurkat cells, a human T-cell line

1993 • 47 citations

The role of sphingosine in cell growth regulation and transmembrane signaling.

1993 • 44 citations

Phosphatidic acid elicits calcium mobilization and actin polymerization through a tyrosine kinase-dependent process in human neutrophils: a mechanism for induction of chemotaxis

1997 • 41 citations

Primary Structure and Characterization of the Vanadium Chloroperoxidase from the Fungus Curvularia inaequails

1995 • 41 citations

Purification and characterization of N-ethylmaleimide-insensitive phosphatidic acid phosphohydrolase (PAP2) from rat liver

1995 • 41 citations

Characterization and purification of neutrophil ecto-phosphatidic acid phosphohydrolase

1997 • 35 citations

Phosphatidic acid phosphatase from mammalian tissues: discovery of channel-like proteins with unexpected functions

1997 • 34 citations

The Structures and Properties of Membrane Lipids

1989 • 33 citations

Identification and Characterization of an Ecto-(lyso)phosphatidic Acid Phosphatase in PAM212 Keratinocytes

1994 • 32 citations

Regulation of Phosphatidic Acid Phosphohydrolase by Epidermal Growth Factor

1996 • 29 citations

Identification of phosphatidate phosphohydrolase purified from rat liver membranes on SDS‐polyacrylamide gel electrophoresis

1996 • 26 citations

Transbilayer movement and metabolic fate of ether-linked phosphatidic acid (1-O-Octadecyl-2-acetyl-sn-glycerol 3-phosphate) in guinea pig peritoneal polymorphonuclear leukocytes.

1992 • 26 citations

[58] Lysophospholipase D

1991 • 17 citations

Purification and Characterization of a Polyisoprenyl Phosphate Phosphatase from Pig Brain

1998 • 16 citations

Diacylglycerol pyrophosphate: a novel metabolite in the Trypanosoma cruzi phosphatidic acid metabolism¹

1998 • 16 citations

Role of Sphingolipids in Regulating the Phospholipase D Pathway and Cell Division

1997 • 12 citations

Isolation of a novel ras‐recision gene that is induced by hydrogen peroxide from a mouse osteoblastic cell line, MC3T3‐E1

1995 • 12 citations

Sphingosine-1-Phosphate: Member of a New Class of Lipid Second Messengers

1997 • 5 citations