The IGF-I Receptor in Mitogenesis and Transformation of Mouse Embryo Cells: Role of Receptor Number

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

The insulin signaling system.

1994 • 1,733 citations

Dual control of cell growth by somatomedins and platelet-derived growth factor.

1979 • 926 citations

Plasmid-encoded hygromycin B resistance: the sequence of hygromycin B phosphotransferase gene and its expression in Escherichia coli and Saccharomyces cerevisiae

1983 • 810 citations

Insulin-like growth factors and cancer

1992 • 622 citations

Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor.

1993 • 554 citations

Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts.

1994 • 527 citations

Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation.

1990 • 404 citations

IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3'-kinase.

1993 • 323 citations

Epidermal growth factor (EGF) and somatomedin C regulate G1 progression in competent BALB/c-3T3 cells

1982 • 318 citations

Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src

1995 • 309 citations

A functional insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor.

1994 • 282 citations

Role of IRS-1-GRB-2 complexes in insulin signaling.

1994 • 215 citations

Multiple Hormones Stimulate the Production of Somatomedin by Cultured Human Fibroblasts*

1984 • 143 citations

Variables controlling somatomedin production by cultured human fibroblasts

1983 • 129 citations

Different Effects on Mitogenesis and Transformation of a Mutation at Tyrosine 1251 of the Insulin-like Growth Factor I Receptor

1995 • 119 citations

Growth-promoting effects of insulin-like growth factor-1 (IGF-1) on hematopoietic cells: overexpression of introduced IGF-1 receptor abrogates interleukin-3 dependency of murine factor-dependent cells by a ligand-dependent mechanism

1991 • 112 citations

Long term growth factor exposure and differential tyrosine phosphorylation are required for DNA synthesis in BALB/c 3T3 cells

1993 • 111 citations

Roles of insulinlike growth factor 1 (IGF-1) and the IGF-1 receptor in epidermal growth factor-stimulated growth of 3T3 cells.

1992 • 110 citations

Insulin and insulin-like growth factor I regulate a thyroid-specific nuclear protein that binds to the thyroglobulin promoter.

1992 • 109 citations

Mutational analysis of the mitogenic and transforming activities of the insulin-like growth factor I receptor.

1996 • 104 citations

Platelet-Derived Growth Factor Increases the Activity of the Promoter of the Insulin-like Growth Factor-1 (IGF-1) Receptor Gene

1994 • 103 citations

Mitogenicity and transforming activity of the insulin-like growth factor-I receptor with mutations in the tyrosine kinase domain.

1994 • 101 citations

Structural and functional analysis of the insulin-like growth factor I receptor gene promoter.

1992 • 98 citations

Tissue Growth Factors

1981 • 97 citations

Insulin‐like growth factor I receptor is required for the mitogenic and transforming activities of the platelet‐derived growth factor receptor

1995 • 93 citations

Cloning and characterization of the proximal promoter region of the rat insulin-like growth factor I (IGF-I) receptor gene

1990 • 84 citations

Alterations in the Responsiveness of Senescent Cells to Growth Factors

1989 • 79 citations

Insulin signalling: the role of insulin receptor substrate 1

1994 • 76 citations

Dissociation of Mitogenesis and Transforming Activity by C-Terminal Truncation of the Insulin-like Growth Factor-I Receptor

1995 • 75 citations

Failure of the bovine papillomavirus to transform mouse embryo fibroblasts with a targeted disruption of the insulin-like growth factor I receptor genes

1995 • 73 citations

Molecular cloning of gene sequences that are regulated by insulin-like growth factor I.

1987 • 71 citations

Intracellular Transactivation of the Insulin-like Growth Factor I Receptor by an Epidermal Growth Factor Receptor

1996 • 64 citations

Effect of a mutation at tyrosine 950 of the insulin-like growth factor I receptor on the growth and transformation of cells.

1995 • 47 citations

The relative effects of different types of growth factors on DNA replication, mitosis, and cellular enlargement

1984 • 45 citations

Distinctive effects of the carboxyl-terminal sequence of the insulin-like growth factor I receptor on its signaling functions

1993 • 39 citations

Compartmentalization of Autocrine Signal Transduction Pathways in Sis-transformed NIH 3T3 Cells

1995 • 38 citations

The role of the IGF1 receptor in the regulation of cdc2 mRNA levels in fibroblasts

1992 • 37 citations

Activation of the ribosomal DNA promoter in cells exposed to insulinlike growth factor I.

1987 • 37 citations

IGF-I increases C-fos expression in FRTL5 rat thyroid cells by activating the C-fos promoter

1988 • 31 citations

The double life of the IGF-1 receptor.

1992 • 26 citations

Stimulatory Effect of PDGF on HMG-CoA Reductase Activity and N-Linked Glycosylation Contributes to Increased Expression of IGF-1 Receptors in Human Fibroblasts

1996 • 20 citations

Somatomedin-C Binding to Cultured Human Fibroblasts is Dependent onDonor Age and Culture Density*

1986 • 15 citations

Insulin-like growth factor I stimulates transcription of the c-jun proto-oncogene in Balbc 3T3 cells

1992 • 14 citations

Mid-G1 arrest and epidermal growth factor independence of ras-transfected mouse cells.

1989 • 7 citations

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