Growth-promoting effects of insulin-like growth factor-1 (IGF-1) on hematopoietic cells: overexpression of introduced IGF-1 receptor abrogates interleukin-3 dependency of murine factor-dependent cells by a ligand-dependent mechanism

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

1984 • 2,564 citations

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

Insulin-Like Growth Factors I and II. Peptide, Messenger Ribonucleic Acid and Gene Structures, Serum, and Tissue Concentrations*

1989 • 1,796 citations

Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.

1987 • 1,627 citations

The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1

1985 • 1,590 citations

Actions of Insulin-Like Growth Factors

1985 • 1,141 citations

Dual control of cell growth by somatomedins and platelet-derived growth factor.

1979 • 926 citations

Growth of factor-dependent hemopoietic precursor cell lines.

1980 • 793 citations

Biologic properties of homogeneous interleukin 3. I. Demonstration of WEHI-3 growth factor activity, mast cell growth factor activity, P cell-stimulating factor activity, colony-stimulating factor activity, and histamine-producing cell-stimulating factor activity

1983 • 702 citations

The Nature and Regulation of the Receptors for Insulin-Like Growth Factors

1985 • 639 citations

Novel myc oncogene RNA from abortive immunoglobulin-gene recombination in mouse plasmacytomas

1982 • 471 citations

Monoclonal antibodies to receptors for insulin and somatomedin-C.

1983 • 423 citations

Cloning of an Interleukin-3 Receptor Gene: a Member of a Distinct Receptor Gene Family

1990 • 417 citations

Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation.

1990 • 404 citations

Somatomedin-C stimulates the phosphorylation of the beta-subunit of its own receptor.

1983 • 395 citations

Neoplastic transformation of mast cells by Abelson-MuLV: abrogation of IL-3 dependence by a nonautocrine mechanism

1985 • 330 citations

Expression and characterization of a functional human insulin-like growth factor I receptor.

1988 • 313 citations

Malignant transformation of a growth factor-dependent myeloid cell line by Abelson virus without evidence of an autocrine mechanism

1985 • 272 citations

Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts.

1986 • 269 citations

Insulin-like growth factor-I can mediate autocrine proliferation of human small cell lung cancer cell lines in vitro.

1988 • 247 citations

Signal Transduction Through the EGF Receptor Transfected in IL-3-Dependent Hematopoietic Cells

1988 • 238 citations

Hematopoietic growth factors activate the tyrosine phosphorylation of distinct sets of proteins in interleukin-3-dependent murine cell lines.

1988 • 222 citations

An antibody to the receptor for insulin-like growth factor I inhibits the growth of MCF-7 cells in tissue culture

1987 • 155 citations

Evidence for specific receptors for interleukin 3 on lymphokine-dependent cell lines established from long-term bone marrow cultures.

1984 • 155 citations

The Panspecific Hemopoietin of Activated T Lymphocytes (Interleukin-3)

1986 • 149 citations

3 Paracrine functions of somatomedins

1986 • 140 citations

Growth regulation of human breast carcinoma occurs through regulated growth factor secretion

1987 • 139 citations

Tyrosine kinase oncogenes abrogate interleukin-3 dependence of murine myeloid cells through signaling pathways involving c-myc: conditional regulation of c-myc transcription by temperature-sensitive v-abl.

1989 • 136 citations

Expression of insulin-like growth factor-I and -II genes in human smooth muscle tumours.

1988 • 121 citations

Stimulation of factor-dependent myeloid cell lines with interleukin 3 induces tyrosine phosphorylation of several cellular substrates.

1988 • 117 citations

Effect of an anti-insulin-like growth factor I receptor antibody on insulin-like growth factor II stimulation of DNA synthesis in human fibroblasts

1986 • 98 citations

Autocrine function for insulin-like growth factor I in human small cell lung cancer cell lines and fresh tumor cells

1991 • 97 citations

Activity in fetal bovine serum that stimulates erythroid colony formation in fetal mouse livers is insulinlike growth factor I.

1985 • 85 citations

Interleukin-3, GM-CSF, and TPA induce distinct phosphorylation events in an interleukin 3-dependent multipotential cell line

1989 • 78 citations

Role of myc in the abrogation of IL3 dependence of myeloid FDC-P1 cells.

1987 • 75 citations

Friend murine leukemia virus-immortalized myeloid cells are converted into tumorigenic cell lines by Abelson leukemia virus.

1985 • 68 citations

Production of immunoreactive insulin-like growth factor I and response to exogenous IGF-I in small cell lung cancer cell lines

1988 • 64 citations

Somatomedin-C/insulin-like growth factor-I is a mitogen for human small cell lung cancer

1988 • 63 citations

Mechanism of Autocrine Stimulation in Hematopoietic Cells Producing Interleukin-3 after Retrovirus-Mediated Gene Transfer

1989 • 62 citations

Reversible dependence on growth factor interleukin-3 in myeloid cells expressing temperature sensitive v-abl oncogene.

1988 • 54 citations

Generation of an autocrine leukaemia using a retroviral expression vector carrying the interleukin-3 gene.

1986 • 51 citations

Activation of transforming potential of the human insulin receptor gene.

1987 • 46 citations

Transduction of Human Colony-Stimulating Factor-1 (CSF-1) Receptor into Interleukin-3-Dependent Mouse Myeloid Cells Induces Both CSF-1-Dependent and Factor-Independent Growth

1989 • 31 citations

Activation and growth of colony-stimulating factor-dependent cell lines is cell cycle stage dependent.

1987 • 28 citations

Coinfection with viruses carrying the v-Ha-ras and v-myc oncogenes leads to growth factor independence by an indirect mechanism.

1986 • 27 citations

Effects of phorbol esters on an interleukin-3-dependent cell line

1990 • 25 citations

Interleukin-3 and phorbol esters induce different patterns of immediate-early gene expression in an interleukin-3 dependent cell line.

1991 • 21 citations

Interleukin 3 stimulation of tyrosine kinase activity in FDC-P1 cells

1988 • 20 citations

Interleukin-2 induces a rapid increase in ornithine decarboxylase mRNA in a cloned murine T lymphocytic cell line

1989 • 14 citations

Interleukin 3 and phorbol ester stimulate tyrosine phosphorylation of overlapping substrate proteins

1989 • 10 citations