Expression of surrogate light chain receptors is restricted to a late stage in pre-B cell differentiation

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

A New Mouse Myeloma Cell Line that Has Lost Immunoglobulin Expression but Permits the Construction of Antibody-Secreting Hybrid Cell Lines

1979 • 1,885 citations

Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells.

1984 • 1,193 citations

Posttranslational association of immunoglobulin heavy chain binding protein with nascent heavy chains in nonsecreting and secreting hybridomas.

1986 • 896 citations

Immunoglobulin heavy chain binding protein

1983 • 849 citations

Surface IgM-kappa specificity on a Burkitt lymphoma cell in vivo and in derived culture lines.

1968 • 833 citations

CYTOLOGY OF BURKITT'S TUMOUR (AFRICAN LYMPHOMA)

1964 • 627 citations

Immunoglobulin gene rearrangement and cell surface antigen expression in acute lymphocytic leukemias of T cell and B cell precursor origins.

1983 • 605 citations

A critical role of λ5 protein in B cell development

1992 • 583 citations

Antigen Receptors on B Lymphocytes

1992 • 509 citations

Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription

1989 • 432 citations

Targeted disruption of µ chain membrane exon causes loss of heavy-chain allelic exclusion

1992 • 376 citations

The proteins encoded by the VpreB and lambda 5 pre-B cell-specific genes can associate with each other and with mu heavy chain.

1990 • 352 citations

Molecular and cellular origins of B lymphocyte diversity

1991 • 346 citations

Assembly and secretion of heavy chains that do not associate posttranslationally with immunoglobulin heavy chain-binding protein.

1987 • 343 citations

Human acute leukemia cell line with the t(4;11) chromosomal rearrangement exhibits B lineage and monocytic characteristics

1985 • 331 citations

A second gene, VpreB in the lambda 5 locus of the mouse, which appears to be selectively expressed in pre-B lymphocytes.

1987 • 306 citations

λ5, a new light-chain-related locus selectively expressed in pre-B lymphocytes

1986 • 302 citations

Anti‐immunoglobulin antibodies induce apoptosis in immature B cell lymphomas

1990 • 253 citations

The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface.

1990 • 221 citations

The B-cell antigen receptor complex

1991 • 213 citations

Interaction of BiP with newly synthesized immunoglobulin light chain molecules: cycles of sequential binding and release.

1992 • 187 citations

Activation of V kappa gene rearrangement in pre-B cells follows the expression of membrane-bound immunoglobulin heavy chains.

1987 • 187 citations

Formation of disulphide-linked µ2ω2 tetramers in pre-B cells by the 18K ω-immunoglobulin light chain

1987 • 179 citations

The CH Series of Murine B Cell Lymphomas: Neoplastic Analogues of Ly‐1⁺ Normal B Cells

1986 • 161 citations

Organization of the murine Ig-related lambda 5 gene transcribed selectively in pre-B lymphocytes.

1987 • 150 citations

Two new acute lymphoblastic leukemia cell lines with early B-cell phenotypes

1982 • 141 citations

The IgM-associated protein mb-1 as a marker of normal and neoplastic B cells

1991 • 133 citations

Analysis of structural properties and cellular distribution of avian Ia antigen by using monoclonal antibody to monomorphic determinants.

1984 • 132 citations

Retention of lymphocyte characteristics by myelomas and theta + -lymphomas: sensitivity to cortisol and phytohemagglutinin.

1973 • 128 citations

Signaling through surface IgM in tolerance-susceptible immature murine B lymphocytes. Developmentally regulated differences in transmembrane signaling in splenic B cells from adult and neonatal mice.

1991 • 111 citations

Effects of Anti‐Ig Antibodies on the Development and Differentiation of B Cells

1980 • 110 citations

Normal pre-B cells express a receptor complex of mu heavy chains and surrogate light-chain proteins.

1991 • 109 citations

PROLIFERATION AND DIFFERENTIATION OF LYMPHOID CELLS: STUDIES WITH HUMAN LYMPHOID CELL LINES AND IMMUNOGLOBULIN SYNTHESIS

1971 • 108 citations

Mu heavy chains can associate with a pseudo-light chain complex (ψL) in human pre-B cell lines

1989 • 105 citations

Light-chain gene expression before heavy-chain gene rearrangement in pre-B cells transformed by Epstein-Barr virus.

1989 • 97 citations

Pre-B cells: bone marrow persistence in anti-mu-suppressed mice, conversion to B lymphocytes, and recovery after destruction by cyclophosphamide.

1978 • 88 citations

Structure and pre-B lymphocyte restricted expression of the VpreB in humans and conservation of its structure in other mammalian species.

1988 • 84 citations

Crosslinking of the cell surface immunoglobulin (μ-surrogate light chains complex) on pre-B cells induces activation of V gene rearrangements at the immunoglobulin κ locus

1992 • 83 citations

Activation of human B cells and inhibition of their terminal differentiation by monoclonal anti-mu antibodies.

1985 • 82 citations

The omega/lambda 5 surrogate immunoglobulin light chain is expressed on the surface of transitional B lymphocytes in murine bone marrow.

1991 • 79 citations

Isolation of a cDNA copy of an RNA species expressed in murine pre-B cells.

1986 • 78 citations

Multiparameter flow cytometric analysis of human fetal bone marrow B cells.

1990 • 78 citations

The immunoglobulin light chain related protein λ5 is expressed on the surface of mouse pre-B cell lines and can function as a signal transducing molecule

1991 • 77 citations

Two types of mu chain complexes are expressed during differentiation from pre-B to mature B cells.

1990 • 76 citations

Identification of three new Ig lambda-like genes in man.

1986 • 76 citations

Anti-IgM antibody-induced cell death in a human B lymphoma cell line, B104, represents a novel programmed cell death.

1992 • 73 citations

Membrane IgM and IgD molecules fail to transduce Ca2+ mobilizing signals when expressed on differentiated B lineage cells.

1990 • 67 citations

Heterogeneity of immunoglobulin-associated molecules on human B cells identified by monoclonal antibodies.

1992 • 65 citations

Establishment of a leukemic cell model for studying human pre-B to B cell differentiation.

1989 • 63 citations

The Omega and Iota Surrogate Immunoglobulin Light Chains

1988 • 56 citations

Cell surface expression of the short immunoglobulin μ chain (Dμ protein) in murine pre-B cells is differently regulated from that of the intact μ chain

1991 • 52 citations

Induced rearrangement of kappa genes in the BLIN-1 human pre-B cell line correlates with germline J-C kappa and V kappa transcription.

1991 • 51 citations

Characterization of a novel human pre-B leukemia cell line.

1981 • 46 citations

Monoclonal anti-Id antibodies react with varying proportions of human B lineage cells.

1987 • 44 citations

Differentiation of normal human pre-B cells in vitro.

1990 • 43 citations

B-Cell Differentiation

2020 • 39 citations

Anti-IgM but not anti-IgD antibodies inhibit cell division of normal human mature B cells.

1992 • 34 citations

Stromal‐Cell and Cytokine‐Dependent Lymphocyte Clones Which Span the Pre‐B‐ to B‐Cell Transition

1990 • 28 citations

Structure, Control of Expression and Putative Function of the PreB Cell-Specific Genes VpreB and λ5

1989 • 28 citations

Lambda-like and V pre-B genes expression: an early B-lineage marker of human leukemias

1991 • 27 citations

Regulation of bone marrow lymphocyte production

1983 • 23 citations

Regulated expression of cell surface antigens during B cell development.

1990 • 19 citations

WEHI-231 AS A TUMOR MODEL FOR TOLERANCE INDUCTION IN IMMATURE B LYMPHOCYTES

1982 • 19 citations

VpreB gene expression in hematopoietic malignancies: a lineage- and stage-restricted marker for B-cell precursor leukemias

1991 • 18 citations

Telling one particle from another

1987 • 9 citations

Japanese budget: Science benefits despite cuts elsewhere

1984 • 6 citations