Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

p53: A Frequent Target for Genetic Abnormalities in Lung Cancer

1989 • 1,214 citations

Functional inactivation of genes by dominant negative mutations

1987 • 1,174 citations

Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life.

1988 • 1,140 citations

Monoclonal antibodies specific for simian virus 40 tumor antigens

1981 • 1,110 citations

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

1990 • 978 citations

Isolation of a transforming sequence from a human bladder carcinoma cell line

1982 • 776 citations

Participation of p53 cellular tumour antigen in transformation of normal embryonic cells

1984 • 754 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse.

1979 • 736 citations

Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation

1989 • 599 citations

Growth regulation of a cellular tumour antigen, p53, in nontransformed cells

1984 • 524 citations

The gapped duplex DNA approach to oligonucleotide-directed mutation construction

1984 • 511 citations

Rearrangement of the p53 gene in human osteogenic sarcomas.

1987 • 489 citations

OxyR, a positive regulator of hydrogen peroxide-inducible genes in Escherichia coli and Salmonella typhimurium, is homologous to a family of bacterial regulatory proteins.

1989 • 415 citations

Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells.

1985 • 414 citations

Specific interaction between the p53 cellular tumour antigen and major heat shock proteins

1986 • 354 citations

Rearrangements of the cellular p53 gene in erythroleukaemic cells transformed by Friend virus

1985 • 334 citations

Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia.

1989 • 300 citations

Monoclonal antibody analysis of p53 expression in normal and transformed cells

1986 • 285 citations

Microinjection of monoclonal antibody to protein p53 inhibits serum-induced DNA synthesis in 3T3 cells.

1982 • 279 citations

Meth A fibrosarcoma cells express two transforming mutant p53 species.

1988 • 247 citations

Study of a temperature-sensitive mutant of the ras-related YPT1 gene product in yeast suggests a role in the regulation of intracellular calcium

1988 • 243 citations

Immunological evidence for the association of p53 with a heat shock protein, hsc70, in p53-plus-ras-transformed cell lines.

1987 • 237 citations

Overproduction of p53 antigen makes established cells highly tumorigenic

1985 • 217 citations

Role of the p53 protein in cell proliferation as studied by microinjection of monoclonal antibodies.

1984 • 216 citations

Analysis of the gene coding for the murine cellular tumour antigen p53.

1984 • 182 citations

The cellular oncogene p53 can be activated by mutagenesis

1985 • 181 citations

Mutant p53 proteins bind hsp 72/73 cellular heat shock-related proteins in SV40-transformed monkey cells.

1987 • 162 citations

Immunologically Distinct p53 Molecules Generated by Alternative Splicing

1986 • 120 citations

The p53 cellular tumor antigen: gene structure, expression and protein properties

1985 • 108 citations

RB and the cell cycle: Entrance or exit?

1989 • 93 citations

Characterization of mutant p53-hsp72/73 protein-protein complexes by transient expression in monkey COS cells.

1988 • 72 citations

Immunologically distinct p53 molecules generated by alternative splicing.

1986 • 64 citations

Biological and Molecular Analysis of P53 Cellular-Encoded Tumor Antigen

1985 • 55 citations

The structural relationships between 54,000-molecular-weight cellular tumor antigens detected in viral- and nonviral-transformed cells

1981 • 55 citations

Co-operation between the p53 protein tumor antigen and platelet-poor plasma in the induction of cellular DNA synthesis

1986 • 49 citations

Permanent expression of p53 in FR 3T3 rat cells but cell cycle-dependent association with large-T antigen in simian virus 40 transformants.

1985 • 17 citations

Structure and activity of the translocated c-myc in mouse plasmacytoma XRPC-24

1986 • 11 citations