Wild-Type p53 Induces Diverse Effects in 32D Cells Expressing Different Oncogenes

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Bone Marrow Transplant

2001 • 3,479 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

Correlation of Terminal Cell Cycle Arrest of Skeletal Muscle with Induction of p21 by MyoD

1995 • 1,154 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

Identification of p53 as a Sequence-Specific DNA-Binding Protein

1991 • 1,109 citations

The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells

1989 • 1,097 citations

Current Protocols in Molecular Biology

1989 • 1,007 citations

Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis

1990 • 945 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?

1993 • 799 citations

Clonal expansion of p53 mutant cells is associated with brain tumour progression

1992 • 687 citations

Wild-type p53 activates transcription in vitro

1992 • 609 citations

Control of normal cell differentiation and the phenotypic reversion of malignancy in myeloid leukaemia

1978 • 593 citations

Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines.

1983 • 559 citations

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.

1991 • 544 citations

Genetic Mechanisms of Tumor Suppression by the Human p53 Gene

1990 • 540 citations

Induction of p21 (WAF-1/CIP1) during differentiation.

1994 • 493 citations

Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1

1994 • 490 citations

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors

1993 • 465 citations

p53 mutation is associated with progression in follicular lymphomas

1993 • 394 citations

Growth factor modulation of p53-mediated growth arrest versus apoptosis.

1995 • 377 citations

Cytokine-dependent granulocytic differentiation. Regulation of proliferative and differentiative responses in a murine progenitor cell line.

1987 • 369 citations

Leukemia and the disruption of normal hematopoiesis

1991 • 357 citations

Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia.

1989 • 300 citations

The nuclear tyrosine kinase c-abl negatively regulates cell growth

1994 • 277 citations

Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor.

1993 • 238 citations

Constitutive production of a unique lymphokine (IL 3) by the WEHI-3 cell line.

1982 • 227 citations

Specific growth response of ras-transformed embryo fibroblasts to tumour promoters

1985 • 210 citations

Cell cycle analysis of p53-induced cell death in murine erythroleukemia cells.

1993 • 196 citations

Abl tyrosine kinase in signal transduction and cell-cycle regulation

1993 • 177 citations

Involvement of wild-type p53 in pre-B-cell differentiation in vitro.

1991 • 168 citations

Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3 withdrawal.

1994 • 168 citations

Expression of wild-type p53 is not compatible with continued growth of p53-negative tumor cells.

1991 • 117 citations

Macrophage-colony-stimulating factor (CSF-1) induces proliferation, chemotaxis, and reversible monocytic differentiation in myeloid progenitor cells transfected with the human c-fms/CSF-1 receptor cDNA.

1990 • 112 citations

Selection of lineage-restricted cell lines immortalized at different stages of hematopoietic differentiation from the murine cell line 32D.

1989 • 96 citations

Effect of Abelson murine leukemia virus on granulocytic differentiation and interleukin-3 dependence of a murine progenitor cell line.

1987 • 88 citations

Interleukin 3-dependent hematopoietic progenitor cell lines.

1983 • 83 citations

Expression of the normal p53 gene induces differentiation of K562 cells.

1992 • 83 citations

Suppression of acute lymphoblastic leukemia by the human wild-type p53 gene.

1992 • 70 citations

The cell cycle and c-Src

1993 • 66 citations

Wild-type p53 gene expression induces granulocytic differentiation of HL-60 cells

1994 • 61 citations

Wild-type p53 modulates apoptosis of normal, IL-3 deprived, hematopoietic cells.

1995 • 55 citations

Abrogation of IL-3 dependent growth requires a functional v-src gene product: evidence for an autocrine growth cycle.

1990 • 46 citations

v-myb blocks granulocyte colony-stimulating factor-induced myeloid cell differentiation but not proliferation.

1993 • 45 citations

Alteration of growth and differentiation factors response by Kirsten and Harvey sarcoma viruses in the IL-3-dependent murine hematopoietic cell line 32D C13(G).

1989 • 29 citations

Involvement of the tumor suppressor gene p53 in tumor necrosis factor-induced differentiation of the leukemic cell line K562.

1995 • 27 citations

The v-src oncogene blocks the differentiation of a murine myeloid progenitor cell line and induces a tumorigenic phenotype.

1991 • 27 citations

p53 as a potential target in cancer therapy.

1992 • 17 citations

Wild Type p53 Activity Contributes to Dependence on Hematopoietic Survival Factors

1994 • 8 citations