Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts.

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1993 • 2,880 citations

Role of insulin-like growth factors in embryonic and postnatal growth

1993 • 2,349 citations

Growth Factors and Cancer

1991 • 2,044 citations

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting

1990 • 1,650 citations

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1993 • 1,236 citations

SIGNALLING BY RECEPTOR TYROSINE KINASES

1993 • 1,098 citations

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts.

1993 • 1,057 citations

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 • 1,026 citations

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1993 • 972 citations

Insulin-like growth factors and their binding proteins

1990 • 929 citations

Dual control of cell growth by somatomedins and platelet-derived growth factor.

1979 • 926 citations

Plasmid-encoded hygromycin B resistance: the sequence of hygromycin B phosphotransferase gene and its expression in Escherichia coli and Saccharomyces cerevisiae

1983 • 810 citations

Cyclin-Dependent Regulation of G ₁ in Mammalian Fibroblasts

1993 • 767 citations

Requirement for c-ras proteins during viral oncogene transformation

1986 • 680 citations

Role of insulin-like growth factors in embryonic and postnatal growth

1993 • 644 citations

The Function of GRB2 in Linking the Insulin Receptor to Ras Signaling Pathways

1993 • 629 citations

Insulin-like growth factors and cancer

1992 • 622 citations

The pathway to signal achievement

1993 • 563 citations

Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor.

1993 • 554 citations

Repression of the Insulin-Like Growth Factor II Gene by the Wilms Tumor Suppressor WT1

1992 • 535 citations

Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation.

1990 • 404 citations

The biology of cell reproduction

1985 • 403 citations

Protein kinase C ζ isoform is critical for mitogenic signal transduction

1993 • 383 citations

The biology of cell reproduction

1985 • 375 citations

Platelet-derived growth factor and the regulation of the mammalian fibroblast cell cycle

1979 • 374 citations

Epidermal growth factor (EGF) and somatomedin C regulate G1 progression in competent BALB/c-3T3 cells

1982 • 318 citations

Binding of the Ras Activator Son of Sevenless to Insulin Receptor Substrate-1 Signaling Complexes

1993 • 298 citations

Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3).

1993 • 247 citations

Inhibition of growth of prostatic cancer cell lines by peptide analogues of insulin-like growth factor 1.

1993 • 240 citations

Cellular substrates of p34cdc2 and its companion cyclin-dependent kinases

1993 • 235 citations

Suppression of oncogene-induced transformation by a deletion mutant of c-jun.

1993 • 227 citations

Inositides and the nucleus and inositides in the nucleus

1993 • 209 citations

Expression in mammalian cells of a gene fromStreptomyces albonigerconferring puromycin resistance

1986 • 183 citations

Inhibition of cellular proliferation by peptide analogues of insulin-like growth factor 1.

1992 • 183 citations

Regulation of G1/S transition by cyclins D2 and D3 in hematopoietic cells.

1993 • 179 citations

The role of p21ras in receptor tyrosine kinase signaling

1995 • 166 citations

Constitutive expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor abrogates all requirements for exogenous growth factors.

1992 • 159 citations

Receptor tyrosine kinase substrates: src homology domains and signal transduction

1992 • 156 citations

The role of the IGF‐I receptor in the growth and transformation of mammalian cells

1994 • 151 citations

Inhibition of the mitogenic effects of plasma by a monoclonal antibody to somatomedin C.

1984 • 142 citations

Two dominant inhibitory mutants of p21ras interfere with insulin-induced gene expression.

1991 • 138 citations

Cell growth and division. A practical approach.

1990 • 135 citations

The assembly of signalling complexes by receptor tyrosine kinases

1993 • 130 citations

Functional expression of insulin receptor substrate-1 is required for insulin-stimulated mitogenic signaling.

1993 • 116 citations

Post-transcriptional control of the onset of DNA synthesis by an insulin-like growth factor.

1984 • 113 citations

Roles of insulinlike growth factor 1 (IGF-1) and the IGF-1 receptor in epidermal growth factor-stimulated growth of 3T3 cells.

1992 • 110 citations

Cell cycle and growth control.

1993 • 110 citations

Ash/Grb-2, a SH2/SH3-containing protein, couples to signaling for mitogenesis and cytoskeletal reorganization by EGF and PDGF.

1993 • 108 citations

Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 2

1993 • 100 citations

The growth-stimulatory effect of simian virus 40 T antigen requires the interaction of insulinlike growth factor 1 with its receptor.

1992 • 99 citations

Spontaneous and Virus Induced Transformation in Cell Culture

1971 • 96 citations

The insulin-like growth factor 1 receptor is required for the proliferation of hemopoietic cells.

1992 • 82 citations

Transphosphorylation as a possible mechanism for insulin and epidermal growth factor receptor activation.

1990 • 80 citations

Alterations in the Responsiveness of Senescent Cells to Growth Factors

1989 • 79 citations

Spontaneous and Virus Induced Transformation in Cell Culture

1971 • 75 citations

Cytokines and cell growth control.

1991 • 64 citations

Hydrolysis of Phosphatidylcholine Is Stimulated by Ras Proteins during Mitogenic Signal Transduction

1992 • 59 citations

c-ras-Ha Gene Expression Is Regulated by Insulin or Insulinlike Growth Factor and by Epidermal Growth Factor in Murine Fibroblasts

1989 • 58 citations

Cell cycle and growth control

1994 • 58 citations

The role of the insulin-like growth factor I receptor in the transformation by simian virus 40 T antigen.

1994 • 58 citations

Interactions of growth factors and retroviral oncogenes with mitogenic signal transduction pathways of Balb/MK keratinocytes.

1988 • 49 citations

Post-Transcriptional Control of the Onset of DNA Synthesis by an Insulin-Like Growth Factor

1984 • 38 citations

The role of the IGF1 receptor in the regulation of cdc2 mRNA levels in fibroblasts

1992 • 37 citations

Cyclin D1 messenger RNA is inducible by platelet-derived growth factor in cultured fibroblasts.

1992 • 37 citations

Hydrolysis of phosphatidylcholine is stimulated by Ras proteins during mitogenic signal transduction.

1992 • 36 citations

c-ras-Ha gene expression is regulated by insulin or insulinlike growth factor and by epidermal growth factor in murine fibroblasts.

1989 • 33 citations

The double life of the IGF-1 receptor.

1992 • 26 citations

Insulin-like Growth Factor-I Unresponsiveness in an Efe Pygmy

1993 • 24 citations

The role of the IGF‐1 receptor in the stimulation of cells by short pulses of growth factors

1993 • 21 citations

Abrogation of the requirements for added growth factors in 3T3 cells constitutively expressing the p53 and IGF-1 genes.

1988 • 20 citations

Isolation of Recessive (Mediator^–) Revertants from NIH 3T3 Cells Transformed with a c-H-ras Oncogene

1990 • 15 citations

Inhibition of the mitogenic effects of plasma by a monoclonal antibody to somatomedin C.

1984 • 14 citations

Mid-G1 arrest and epidermal growth factor independence of ras-transfected mouse cells.

1989 • 7 citations