Control of matrix metalloproteinase catalytic activity

New functions for the matrix metalloproteinases in cancer progression

2002 • 5,937 citations

How Matrix Metalloproteinases Regulate Cell Behavior

2001 • 3,860 citations

Matrix metalloproteinases and their inhibitors in connective tissue remodeling

1991 • 3,309 citations

Matrix metalloproteinases and the regulation of tissue remodelling

2007 • 2,742 citations

Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations

2002 • 2,711 citations

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis.

2000 • 1,945 citations

Heparin-Protein Interactions

2002 • 1,835 citations

Matrix metalloproteinases as modulators of inflammation and innate immunity

2004 • 1,833 citations

Mechanisms, challenges and opportunities in stroke

2003 • 1,688 citations

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis

2000 • 1,604 citations

Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase

1995 • 1,576 citations

Localization of Matrix Metalloproteinase MMP-2 to the Surface of Invasive Cells by Interaction with Integrin αvβ3

1996 • 1,555 citations

The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.

1990 • 1,423 citations

MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover

1999 • 1,280 citations

Matrix metalloproteinases: effectors of development and normal physiology

2000 • 1,236 citations

Furin at the cutting edge: From protein traffic to embryogenesis and disease

2002 • 1,162 citations

Activation mechanisms of matrix metalloproteinases.

1997 • 1,134 citations

Regulation of Intestinal α-Defensin Activation by the Metalloproteinase Matrilysin in Innate Host Defense

1999 • 1,069 citations

S-Nitrosylation of Matrix Metalloproteinases: Signaling Pathway to Neuronal Cell Death

2002 • 943 citations

Reduced angiogenesis and tumor progression in gelatinase A-deficient mice.

1998 • 887 citations

Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I

2000 • 792 citations

Matrix metalloproteinases: structures, evolution, and diversification

1998 • 759 citations

Matrilysin Shedding of Syndecan-1 Regulates Chemokine Mobilization and Transepithelial Efflux of Neutrophils in Acute Lung Injury

2002 • 734 citations

Astacins, serralysins, snake venom and matrix metalloproteinases exhibit identical zinc‐binding environments (HEXXHXXGXXH and Met‐turn) and topologies and should be grouped into a common family, the ‘metzincins’

1993 • 729 citations

Matrix metalloproteinase degradation of extracellular matrix: biological consequences

1998 • 726 citations

Multiple modes of activation of latent human fibroblast collagenase: evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation.

1990 • 699 citations

Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation

1997 • 664 citations

Membrane Type I Matrix Metalloproteinase Usurps Tumor Growth Control Imposed by the Three-Dimensional Extracellular Matrix

2003 • 659 citations

Furin-dependent intracellular activation of the human stromelysin-3 zymogen

1995 • 620 citations

Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin

1997 • 612 citations

Activation of Matrix Metalloproteinase-9 (MMP-9) via a Converging Plasmin/Stromelysin-1 Cascade Enhances Tumor Cell Invasion

1999 • 583 citations

Heparin-Binding Proteins

1998 • 515 citations

Matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) from HT 1080 human fibrosarcoma cells. Purification and activation of the precursor and enzymic properties.

1992 • 502 citations

Stromelysin is an activator of procollagenase. A study with natural and recombinant enzymes

1987 • 474 citations

Hypochlorous Acid Oxygenates the Cysteine Switch Domain of Pro-matrilysin (MMP-7)

2001 • 473 citations

CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling

2002 • 472 citations

Oxidative Autoactivation of Latent Collagenase by Human Neutrophils

1985 • 466 citations

TIMP-2 Is Required for Efficient Activation of proMMP-2 in Vivo

2000 • 383 citations

Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion

2001 • 382 citations

Matrix metalloproteinases in repair

1999 • 375 citations

Cell Surface Heparan Sulfate Proteoglycans: Selective Regulators of Ligand-Receptor Encounters

2000 • 360 citations

Matrilysin is expressed by lipid-laden macrophages at sites of potential rupture in atherosclerotic lesions and localizes to areas of versican deposition, a proteoglycan substrate for the enzyme.

1996 • 359 citations

Activation of a recombinant membrane type 1‐matrix metalloproteinase (MT1‐MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)‐2

1996 • 358 citations

Plasma membrane-dependent activation of the 72-kDa type IV collagenase is prevented by complex formation with TIMP-2

1993 • 338 citations

The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment

2003 • 333 citations

A Key Role for Mast Cell Chymase in the Activation of Pro-matrix Metalloprotease-9 and Pro-matrix Metalloprotease-2

2004 • 321 citations

Matrilysin (Matrix Metalloproteinase-7) Mediates E-Cadherin Ectodomain Shedding in Injured Lung Epithelium

2003 • 314 citations

Binding of Active (57 kDa) Membrane Type 1-Matrix Metalloproteinase (MT1-MMP) to Tissue Inhibitor of Metalloproteinase (TIMP)-2 Regulates MT1-MMP Processing and Pro-MMP-2 Activation

2000 • 310 citations

The Role of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 in Antibody-Induced Arthritis

2002 • 292 citations

Matrix Metalloproteinase 7 (Matrilysin) from Human Rectal Carcinoma Cells

1995 • 290 citations

Matrilysin expression and function in airway epithelium.

1998 • 277 citations

Functional overlap between two classes of matrix-degrading proteases in wound healing

1999 • 273 citations

The C-terminal Region of Membrane Type Matrix Metalloproteinase Is a Functional Transmembrane Domain Required for Pro-gelatinase A Activation

1995 • 269 citations

Activation of the endogenous metalloproteinase, gelatinase, by triggered human neutrophils.

1986 • 267 citations

Decreased allergic lung inflammatory cell egression and increased susceptibility to asphyxiation in MMP2-deficiency

2002 • 261 citations

Yeast Nuclear Extract Contains Two Major Forms of RNA Polymerase II Mediator Complexes

2001 • 254 citations

Distinct populations of basal keratinocytes express stromelysin-1 and stromelysin-2 in chronic wounds.

1994 • 238 citations

Identification and Enzymatic Characterization of Two Diverging Murine Counterparts of Human Interstitial Collagenase (MMP-1) Expressed at Sites of Embryo Implantation

2001 • 237 citations

Heparan Sulfate Proteoglycans as Extracellular Docking Molecules for Matrilysin (Matrix Metalloproteinase 7)

2000 • 234 citations

Membrane-type matrix metalloproteinase 1 is a gelatinolytic enzyme and is secreted in a complex with tissue inhibitor of metalloproteinases 2.

1996 • 232 citations

Function of the Plasminogen/Plasmin and Matrix Metalloproteinase Systems After Vascular Injury in Mice With Targeted Inactivation of Fibrinolytic System Genes

1998 • 227 citations

Cloning and Characterization of Human MMP-23, a New Matrix Metalloproteinase Predominantly Expressed in Reproductive Tissues and Lacking Conserved Domains in Other Family Members

1999 • 226 citations

Activation of Human Neutrophil Procollagenase by Nitrogen Dioxide and Peroxynitrite: A Novel Mechanism for Procollagenase Activation Involving Nitric Oxide

1997 • 226 citations

The Matrix Metalloproteinase Family

1998 • 225 citations

Matrix Metalloproteinases (MMPs) Regulate Fibrin-invasive Activity via MT1-MMP–dependent and –independent Processes

2002 • 215 citations

Pro-collagenase-1 (Matrix Metalloproteinase-1) Binds the α2β1 Integrin upon Release from Keratinocytes Migrating on Type I Collagen

2001 • 209 citations

MMP-1 activation by serine proteases and MMP-10 induces human capillary tubular network collapse and regression in 3D collagen matrices

2005 • 204 citations

Serglycin Is Essential for Maturation of Mast Cell Secretory Granule

2004 • 193 citations

Cathepsin B Activity Regulation

2001 • 182 citations

MT1‐MMP: A tethered collagenase

2004 • 175 citations

Proteoglycans

2000 • 165 citations

Dog Mast Cell α-Chymase Activates Progelatinase B by Cleaving the Phe88-Gln89 and Phe91-Glu92 Bonds of the Catalytic Domain

1997 • 158 citations

Plasmin activates pro‐matrix metalloproteinase‐2 with a membrane‐type 1 matrix metalloproteinase‐dependent mechanism

2002 • 154 citations

Disruption of the Plasminogen Gene in Mice Abolishes Wound Healing after Myocardial Infarction

2000 • 149 citations

Hypochlorous Acid Generated by Myeloperoxidase Modifies Adjacent Tryptophan and Glycine Residues in the Catalytic Domain of Matrix Metalloproteinase-7 (Matrilysin)

2003 • 148 citations

Inactivating Mutation of the Mouse Tissue Inhibitor of Metalloproteinases-2(Timp-2) Gene Alters ProMMP-2 Activation

2000 • 147 citations

Diminished corneal angiogenesis in gelatinase A‐deficient mice

2001 • 141 citations

Identification of chondroitin sulfate E proteoglycans and heparin proteoglycans in the secretory granules of human lung mast cells.

1988 • 137 citations

Tissue Inhibitor of Metalloproteinase (TIMP)-2 Acts Synergistically with Synthetic Matrix Metalloproteinase (MMP) Inhibitors but Not with TIMP-4 to Enhance the (Membrane Type 1)-MMP-dependent Activation of Pro-MMP-2

2000 • 135 citations

Proteolytic activation of the precursor of membrane type 1 matrix metalloproteinase by human plasmin

1997 • 134 citations

Regulation of human mast cell tryptase. Effects of enzyme concentration, ionic strength and the structure and negative charge density of polysaccharides

1987 • 133 citations

MT1-MMP–dependent, apoptotic remodeling of unmineralized cartilage

2003 • 131 citations

Mast cell expression of gelatinases A and B is regulated by kit ligand and TGF-beta.

1999 • 126 citations

Evidence that human rheumatoid synovial matrix metalloproteinase 3 is an endogenous activator of procollagenase

1988 • 120 citations

Studies on the ability of 65-kDa and 92-kDa tumor cell gelatinases to degrade type IV collagen.

1990 • 118 citations

Membrane Type Matrix Metalloproteinase 1 Activates Pro-gelatinase A without Furin Cleavage of the N-terminal Domain

1996 • 114 citations

Coordinate Expression of Matrix Metalloproteinase Family Members in the Uterus of Normal, Matrilysin-Deficient, and Stromelysin-1-Deficient Mice*

1997 • 112 citations

Reduced Choroidal Neovascular Membrane Formation in Matrix Metalloproteinase-2–Deficient Mice

2003 • 110 citations

Mast Cell Expression of Gelatinases A and B Is Regulated bykitLigand and TGF-β

1999 • 99 citations

Oxidative Cross-linking of Tryptophan to Glycine Restrains Matrix Metalloproteinase Activity

2004 • 92 citations

Activation of membrane-type matrix metalloproteinase 3 zymogen by the proprotein convertase furin in the trans-Golgi network.

2002 • 90 citations

Reduced Retinal Angiogenesis in MMP-2–Deficient Mice

2003 • 89 citations

Cell surface-mediated activation of progelatinase A: demonstration of the involvement of the C-terminal domain of progelatinase A in cell surface binding and activation of progelatinase A by primary fibroblasts

1994 • 88 citations

Mechanism for Activation of Mouse Mast Cell Tryptase: Dependence on Heparin and Acidic pH for Formation of Active Tetramers of Mouse Mast Cell Protease 6

2000 • 83 citations

Macrophages Secrete Matrix Metalloproteinase 9 Covalently Linked to the Core Protein of Chondroitin Sulphate Proteoglycans

2000 • 78 citations

Structural Analysis of the α2 Integrin I Domain/Procollagenase-1 (Matrix Metalloproteinase-1) Interaction

2001 • 71 citations

Pericellular activation of proMMP-7 (promatrilysin-1) through interaction with CD151

2005 • 69 citations

Matrilysin-dependent Elastolysis by Human Macrophages

2003 • 65 citations

Different effects of hypochlorous acid on human neutrophil metalloproteinases: Activation of collagenase and inactivation of collagenase and gelatinase

1992 • 65 citations

What has been learned about the cardiovascular effects of matrix metalloproteinases from mouse models?

2006 • 59 citations

Sequence motifs of tissue inhibitor of metalloproteinases 2 (TIMP-2) determining progelatinase A (proMMP-2) binding and activation by membrane-type metalloproteinase 1 (MT1-MMP)

2003 • 56 citations

The mouse matrix metalloproteinase, epilysin (MMP-28), is alternatively spliced and processed by a furin-like proprotein convertase

2003 • 50 citations

Mechanism by Which Heparin Proteoglycan Modulates Mast Cell Chymase Activity

1999 • 49 citations

Calcium‐induced activation and truncation of promatrix metalloproteinase‐9 linked to the core protein of chondroitin sulfate proteoglycans

2003 • 49 citations

Binding of Active Matrilysin to Cell Surface Cholesterol Sulfate Is Essential for Its Membrane-associated Proteolytic Action and Induction of Homotypic Cell Adhesion

2006 • 44 citations

Coordinate Expression of Matrix Metalloproteinase Family Members in the Uterus of Normal, Matrilysin-Deficient, and Stromelysin-1-Deficient Mice

1997 • 44 citations

Independent regulation of matrix metalloproteinases and plasminogen activators in human fibrosarcoma cells

1996 • 36 citations

MT1-MMP-Dependent and -Independent Regulation of Gelatinase A Activation in Long-Term, Ascorbate-Treated Fibroblast Cultures: Regulation by Fibrillar Collagen

2002 • 27 citations

Serglycin Proteoglycans: The Family of Proteoglycans Stored in the Secretory Granules of Certain Effector Cells of the Immune System

2000 • 12 citations

Matrix Metalloproteinases

1997 • 3 citations