Matrilysin (Matrix Metalloproteinase-7) Mediates E-Cadherin Ectodomain Shedding in Injured Lung Epithelium

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis.

2000 • 1,945 citations

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis

2000 • 1,604 citations

Localization of Matrix Metalloproteinase MMP-2 to the Surface of Invasive Cells by Interaction with Integrin αvβ3

1996 • 1,555 citations

Requirement for Macrophage Elastase for Cigarette Smoke-Induced Emphysema in Mice

1997 • 1,463 citations

Damage of the Airway Epithelium and Bronchial Reactivity in Patients with Asthma

1985 • 1,315 citations

A continuous tumor‐cell line from a human lung carcinoma with properties of type II alveolar epithelial cells

1976 • 1,224 citations

Matrix metalloproteinases: a tail of a frog that became a prince

2002 • 1,082 citations

Regulation of Intestinal α-Defensin Activation by the Metalloproteinase Matrilysin in Innate Host Defense

1999 • 1,069 citations

Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness

1994 • 1,018 citations

Bronchial Biopsies in Asthma: An Ultrastructural, Quantitative Study and Correlation with Hyperreactivity

1989 • 973 citations

Idiopathic Pulmonary Fibrosis

2001 • 956 citations

MOLECULAR AND FUNCTIONAL ANALYSIS OF CADHERIN-BASED ADHERENS JUNCTIONS

1997 • 800 citations

Regulation of Cadherin Adhesive Activity

2000 • 793 citations

Matrilysin Shedding of Syndecan-1 Regulates Chemokine Mobilization and Transepithelial Efflux of Neutrophils in Acute Lung Injury

2002 • 734 citations

A comparison of the quantitative anatomy of the bronchi in normal subjects, in status asthmaticus, in chronic bronchitis, and in emphysema

1969 • 704 citations

Alveolar epithelial type II cell: defender of the alveolus revisited

2001 • 703 citations

Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1

2001 • 685 citations

The metalloproteinase matrilysin is a target of β-catenin transactivation in intestinal tumors

1999 • 679 citations

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

2002 • 676 citations

Matrix Metalloproteinase Stromelysin-1 Triggers a Cascade of Molecular Alterations That Leads to Stable Epithelial-to-Mesenchymal Conversion and a Premalignant Phenotype in Mammary Epithelial Cells

1997 • 633 citations

Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin

1997 • 612 citations

Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans

2002 • 600 citations

STRUCTURAL ALTERATIONS OF LUNG PARENCHYMA IN THE ADULT RESPIRATORY DISTRESS SYNDROME

1982 • 584 citations

Upregulation of Gelatinases A and B, Collagenases 1 and 2, and Increased Parenchymal Cell Death in COPD

2000 • 508 citations

CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling

2002 • 472 citations

The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis

1999 • 421 citations

Matrix metalloproteinases in lung biology

2000 • 377 citations

Plakoglobin and β-catenin: Protein interactions, regulation and biological roles

2000 • 334 citations

Defining interactions and distributions of cadherin and catenin complexes in polarized epithelial cells.

1994 • 326 citations

Matrilysin expression and function in airway epithelium.

1998 • 277 citations

Immunohistochemical study of metalloproteinases and their tissue inhibitors in the lungs of patients with diffuse alveolar damage and idiopathic pulmonary fibrosis.

1996 • 234 citations

Heparan Sulfate Proteoglycans as Extracellular Docking Molecules for Matrilysin (Matrix Metalloproteinase 7)

2000 • 234 citations

Airway Epithelial Cell Migration Dynamics: MMP-9 Role in Cell–Extracellular Matrix Remodeling

1999 • 233 citations

Gelatinase B Is Required for Alveolar Bronchiolization after Intratracheal Bleomycin

2000 • 185 citations

Matrix Metalloproteinase Matrilysin Is Constitutively Expressed in Adult Human Exocrine Epithelium

1995 • 174 citations

Matrilysin mediates extracellular cleavage of E-cadherin from prostate cancer cells: a key mechanism in hepatocyte growth factor/scatter factor-induced cell-cell dissociation and in vitro invasion.

2001 • 168 citations

E-cadherin mediates adhesion and suppresses cell motility via distinct mechanisms

1997 • 165 citations

Epithelial cell-fibroblast interactions in lung injury and repair.

1990 • 161 citations

The metalloproteinase matrilysin is preferentially expressed by epithelial cells in a tissue-restricted pattern in the mouse.

1995 • 150 citations

Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of β-catenin from cell – cell contacts

1999 • 126 citations

Matrix Metalloproteinases Cleave Tissue Factor Pathway Inhibitor: Effects on coagulation

2000 • 117 citations

Matrix Metalloproteinases Cleave Tissue Factor Pathway Inhibitor

2000 • 100 citations

Ultrastructural evidence of alveolar epithelial injury in idiopathic bronchiolitis obliterans-organizing pneumonia.

1988 • 93 citations

Transmodulation of Cell Surface Regulatory Molecules via Ectodomain Shedding

2002 • 92 citations

Role of collagenase in mediating in vitro alveolar epithelial wound repair

1999 • 89 citations

Airway epithelial repair: breathtakingly quick and multipotentially pathogenic

1997 • 86 citations

Regulation of Matrilysin Expression in Airway Epithelial Cells by Pseudomonas aeruginosa Flagellin

2001 • 80 citations

MMP Inhibitors Augment Fibroblast Adhesion through Stabilization of Focal Adhesion Contacts and Up-regulation of Cadherin Function

2001 • 66 citations

Overexpression of the Matrix Metalloproteinase Matrilysin Results in Premature Mammary Gland Differentiation and Male Infertility

1998 • 58 citations

Differential Effects of EGF and Amphiregulin on Adhesion Molecule Expression and Migration of Colon Carcinoma Cells

1997 • 57 citations

Lung alveolar epithelial cell migration in vitro: modulators and regulation processes

1996 • 51 citations

The distribution of adhesive mechanisms in the normal bronchial epithelium

1993 • 44 citations

Overexpression of Matrix Metalloproteinase-7 in Pulmonary Fibrosis

2002 • 40 citations

Response to high frequency jet ventilation may predict the need for extracorporeal membrane oxygenation

1996 • 13 citations

Regulation by calcium of proliferation and morphology of normal human tracheobronchial epithelial cell cultures

1990 • 11 citations

Overexpression of Matrix Metalloproteinase-7 in Pulmonary Fibrosis

2002 • 11 citations

Organ-cultured epithelial tissue as an in vitro model for invasion: quantitation and high-voltage electron microscopy of tumor cell attachment.

1984 • 10 citations