TIMP-2 Is Required for Efficient Activation of proMMP-2 in Vivo

Matrix Metalloproteinases: A Review

1993 • 2,998 citations

A matrix metalloproteinase expressed on the surface of invasive tumour cells

1994 • 2,561 citations

Metastatic potential correlates with enzymatic degradation of basement membrane collagen

1980 • 1,778 citations

Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase

1995 • 1,576 citations

Requirement for Macrophage Elastase for Cigarette Smoke-Induced Emphysema in Mice

1997 • 1,463 citations

The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.

1990 • 1,423 citations

Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix

1995 • 1,184 citations

Regulation of Intestinal α-Defensin Activation by the Metalloproteinase Matrilysin in Innate Host Defense

1999 • 1,069 citations

Tissue Inhibitor of Metalloproteinase (TIMP-2)

1989 • 899 citations

Reduced angiogenesis and tumor progression in gelatinase A-deficient mice.

1998 • 887 citations

Tumor invasion through the human amniotic membrane: Requirement for a proteinase cascade

1986 • 764 citations

Cellular Mechanisms for Human Procollagenase-3 (MMP-13) Activation

1996 • 741 citations

Independent Regulation of Collagenase, 72-kDa Progelatinase, and Metalloendoproteinase Inhibitor Expression in Human Fibroblasts by Transforming Growth Factor-β

1989 • 649 citations

Furin-dependent intracellular activation of the human stromelysin-3 zymogen

1995 • 620 citations

Activation of Matrix Metalloproteinase-9 (MMP-9) via a Converging Plasmin/Stromelysin-1 Cascade Enhances Tumor Cell Invasion

1999 • 583 citations

The TIMP2 Membrane Type 1 Metalloproteinase “Receptor” Regulates the Concentration and Efficient Activation of Progelatinase A

1998 • 578 citations

The Soluble Catalytic Domain of Membrane Type 1 Matrix Metalloproteinase Cleaves the Propeptide of Progelatinase A and Initiates Autoproteolytic Activation

1996 • 564 citations

Molecular Cloning and Characterization of Human Tissue Inhibitor of Metalloproteinase 4

1996 • 547 citations

Transcriptional and post-transcriptional regulation of 72-kDa gelatinase/type IV collagenase by transforming growth factor-beta 1 in human fibroblasts. Comparisons with collagenase and tissue inhibitor of matrix metalloproteinase gene expression

1991 • 461 citations

Mechanisms of activation of tissue procollagenase by matrix metalloproteinase 3 (stromelysin)

1990 • 431 citations

Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts

1990 • 428 citations

Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression [published erratum appears in J Cell Biol 1996 Feb;132(4):following 752]

1994 • 405 citations

In vitro suppression of programmed cell death of B cells by tissue inhibitor of metalloproteinases-1.

1998 • 400 citations

Transmembrane-deletion Mutants of the Membrane-type Matrix Metalloproteinase-1 Process Progelatinase A and Express Intrinsic Matrix-degrading Activity

1996 • 392 citations

Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl)mercuric acetate

1990 • 381 citations

Collagenase expression in the lungs of transgenic mice causes pulmonary emphysema

1992 • 378 citations

Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor

1998 • 360 citations

Activation of a recombinant membrane type 1‐matrix metalloproteinase (MT1‐MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)‐2

1996 • 358 citations

Matrix Metalloproteinase 7 (Matrilysin) from Human Rectal Carcinoma Cells

1995 • 290 citations

A new inhibitor of metalloproteinases from chicken: ChIMP-3. A third member of the TIMP family.

1992 • 274 citations

The C-terminal Region of Membrane Type Matrix Metalloproteinase Is a Functional Transmembrane Domain Required for Pro-gelatinase A Activation

1995 • 269 citations

Involvement of PA/plasmin system in the processing of pro‐MMP‐9 and in the second step of pro‐MMP‐2 activation

1997 • 255 citations

Intermolecular Autolytic Cleavage Can Contribute to the Activation of Progelatinase A by Cell Membranes

1995 • 242 citations

The activation of ProMMP-2 (gelatinase A) by HT1080 fibrosarcoma cells is promoted by culture on a fibronectin substrate and is concomitant with an increase in processing of MT1-MMP (MMP-14) to a 45 kDa form

1998 • 228 citations

cDNA cloning and expression of a metalloproteinase inhibitor related to tissue inhibitor of metalloproteinases.

1990 • 202 citations

The von Hippel-Lindau Tumor Suppressor Gene Inhibits Hepatocyte Growth Factor/Scatter Factor-Induced Invasion and Branching Morphogenesis in Renal Carcinoma Cells

1999 • 200 citations

Matrix Metalloproteinases MMP2 and MMP9 Are Produced in Early Stages of Kidney Morphogenesis but Only MMP9 Is Required for Renal Organogenesis In Vitro

1997 • 183 citations

Membrane‐Type‐2 Matrix Metalloproteinase Can Initiate the Processing of Progelatinase A and is Regulated by the Tissue Inhibitors of Metalloproteinases

1997 • 164 citations

Specific, High Affinity Binding of Tissue Inhibitor of Metalloproteinases-4 (TIMP-4) to the COOH-terminal Hemopexin-like Domain of Human Gelatinase A

1997 • 160 citations

Inactivating Mutation of the Mouse Tissue Inhibitor of Metalloproteinases-2(Timp-2) Gene Alters ProMMP-2 Activation

2000 • 147 citations

Proteolytic activation of the precursor of membrane type 1 matrix metalloproteinase by human plasmin

1997 • 134 citations

Timp-1 Is Important for Epithelial Proliferation and Branching Morphogenesis during Mouse Mammary Development

1999 • 114 citations

Tissue inhibitor of metalloproteinase-2 stimulates mesenchymal growth and regulates epithelial branching during morphogenesis of the rat metanephros

1999 • 106 citations

Steps involved in activation of the complex of pro-matrix metalloproteinase 2 (progelatinase A) and tissue inhibitor of metalloproteinases (TIMP)-2 by 4-aminophenylmercuric acetate

1995 • 103 citations

The breakdown of collagen by chondrocytes

1980 • 102 citations

Role of Tissue Inhibitor of Metalloproteinases-2 (TIMP-2) in Regulation of Pro-Gelatinase A Activation Catalyzed by Membrane-Type Matrix Metalloproteinase-1 (MT1-MMP) in Human Cancer Cells

1998 • 92 citations

The Specificity of TIMP-2 for Matrix Metalloproteinases Can Be Modified by Single Amino Acid Mutations

1999 • 84 citations

Identification of the Tissue Inhibitor of Metalloproteinases-2 (TIMP-2) Binding Site on the Hemopexin Carboxyl Domain of Human Gelatinase A by Site-directed Mutagenesis

1999 • 81 citations

Evidence for the Presence of a Complex of Collagenase with α2-Macroglobulin in Human Rheumatoid Synovial Fluid

1973 • 77 citations

Intracellular activation of gelatinase A (72-kDa type IV collagenase) by normal fibroblasts

1997 • 64 citations

Characterization of Collagenase, other Metallo-Proteinases and An Inhibitor (Timp) Produced by Human Synovium and Cartilage in Culture

1981 • 55 citations

Hyper‐resistance to Infection in TIMP‐1‐Deficient Mice Is Neutrophil Dependent but Not Immune Cell Autonomous

1999 • 17 citations

TIMP‐1 and TIMP‐2 Perform Different Functions in Vivo

1999 • 10 citations