Cell surface-mediated activation of progelatinase A: demonstration of the involvement of the C-terminal domain of progelatinase A in cell surface binding and activation of progelatinase A by primary fibroblasts

Maturation of the head of bacteriophage T4

1973 • 3,781 citations

The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. Application to the radioimmunoassay

1973 • 3,279 citations

Ultrasensitive Stain for Proteins in Polyacrylamide Gels Shows Regional Variation in Cerebrospinal Fluid Proteins

1981 • 2,972 citations

Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates

1980 • 1,991 citations

Analysis of radioligand binding experiments

1985 • 1,247 citations

H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.

1988 • 1,050 citations

Human 92- and 72-kilodalton type IV collagenases are elastases.

1991 • 550 citations

Type IV collagenases in tumor invasion and metastasis

1990 • 502 citations

Matrix metalloproteinase degradation of elastin, type IV collagen and proteoglycan. A quantitative comparison of the activities of 95 kDa and 72 kDa gelatinases, stromelysins-1 and -2 and punctuated metalloproteinase (PUMP)

1991 • 454 citations

Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts

1990 • 428 citations

Independent expression and cellular processing of Mr 72,000 type IV collagenase and interstitial collagenase in human tumorigenic cell lines.

1990 • 379 citations

The Activation of Human Type IV Collagenase Proenzyme

1989 • 347 citations

Plasma membrane-dependent activation of the 72-kDa type IV collagenase is prevented by complex formation with TIMP-2

1993 • 338 citations

The C-terminal domain of 72 kDa gelatinase A is not required for catalysis, but is essential for membrane activation and modulates interactions with tissue inhibitors of metalloproteinases

1992 • 268 citations

Differential roles for two gelatinolytic enzymes of the matrix metalloproteinase family in the remodelling cornea

1991 • 257 citations

The activity of the tissue inhibitors of metalloproteinases is regulated by C-terminal domain interactions: A kinetic analysis of the inhibition of gelatinase A

1993 • 237 citations

Concanavalin A produces a matrix-degradative phenotype in human fibroblasts. Induction and endogenous activation of collagenase, 72-kDa gelatinase, and Pump-1 is accompanied by the suppression of the tissue inhibitor of matrix metalloproteinases.

1990 • 235 citations

The tissue metalloproteinase family and the inhibitor TIMP: a study using cDNAs and recombinant proteins.

1990 • 202 citations

Domain structure of human 72-kDa gelatinase/type IV collagenase. Characterization of proteolytic activity and identification of the tissue inhibitor of metalloproteinase-2 (TIMP-2) binding regions.

1992 • 201 citations

Tissue inhibitor of metalloproteinases-2 inhibits the activation of 72 kDa progelatinase by fibroblast membranes

1991 • 201 citations

Regulation of the autoactivation of human 72-kDa progelatinase by tissue inhibitor of metalloproteinases-2

1991 • 198 citations

Purification and characterization of a bone metalloproteinase that degrades gelatin and types IV and V collagen

1985 • 195 citations

Purification and properties of a gelatin-specific neutral protease from human skin.

1981 • 169 citations

The purification of tissue inhibitor of metalloproteinases-2 from its 72 kDa progelatinase complex. Demonstration of the biochemical similarities of tissue inhibitor of metalloproteinases-2 and tissue inhibitor of metalloproteinases-1

1991 • 164 citations

Substrate specificities and activation mechanisms of matrix metalloproteinases

1991 • 164 citations

Collagen-induced activation of the M(r) 72,000 type IV collagenase in normal and malignant human fibroblastoid cells.

1992 • 154 citations

Metalloproteinases from rabbit bone culture medium degrade types IV and V collagens, laminin and fibronectin

1981 • 138 citations

Binding of tissue inhibitor of metalloproteinases 2 to two distinct sites on human 72-kDa gelatinase. Identification of a stabilization site.

1991 • 138 citations

Cellular activation of the 72 kDa type IV procollagenase/TIMP-2 complex

1993 • 138 citations

Human factor XII (Hageman factor) autoactivation by dextran sulfate. Circular dichroism, fluorescence, and ultraviolet difference spectroscopic studies.

1992 • 122 citations

Human progelatinase A can be activated by autolysis at a rate that is concentration‐dependent and enhanced by heparin bound to the C‐terminal domain

1993 • 99 citations

Surface activation of pro-cathepsin L

1992 • 99 citations

Vapor‐phase modification of sulfhydryl groups in proteins

1987 • 78 citations

Human gingival tissues in culture synthesize three metalloproteinases and a metalloproteinase inhibitor

1982 • 73 citations

Occurrence of an active form of gelatinase in human gastric and colorectal carcinoma tissues

1991 • 46 citations

Cell-mediated degradation of type IV collagen and gelatin films is dependent on the activation of matrix metalloproteinases

1992 • 34 citations