Reduced Retinal Angiogenesis in MMP-2–Deficient Mice

Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations

2002 • 2,711 citations

Oxygen-induced retinopathy in the mouse.

1994 • 1,564 citations

Pigment Epithelium-Derived Factor: A Potent Inhibitor of Angiogenesis

1999 • 1,494 citations

Hyperglycemic Pseudohypoxia and Diabetic Complications

1993 • 1,025 citations

The Family of Matrix Metalloproteinases^a

1994 • 437 citations

Vascular Endothelial Growth Factor Upregulates the Expression of Matrix Metalloproteinases in Vascular Smooth Muscle Cells

1998 • 428 citations

Matrix metalloproteinase-2 is required for the switch to the angiogenic phenotype in a tumor model

2000 • 389 citations

Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1.

1996 • 353 citations

Unaltered Secretion of β-Amyloid Precursor Protein in Gelatinase A (Matrix Metalloproteinase 2)-deficient Mice

1997 • 352 citations

Matrix Metalloproteinases Cleave Connective Tissue Growth Factor and Reactivate Angiogenic Activity of Vascular Endothelial Growth Factor 165

2002 • 348 citations

Plasminogen Activators and Matrix Metalloproteinases in Angiogenesis

1996 • 341 citations

Targeted Disruption of the FGF2 Gene Does Not Prevent Choroidal Neovascularization in a Murine Model

1998 • 324 citations

The Regulation of Neovascularization by Matrix Metalloproteinases and Their Inhibitors

1997 • 304 citations

Experimental metastasis is suppressed in MMP-9-deficient mice.

1999 • 300 citations

Unbalanced expression of VEGF and PEDF in ischemia‐induced retinal neovascularization

2001 • 298 citations

Type IV collagenase(s) and TIMPs modulate endothelial cell morphogenesis in vitro

1993 • 296 citations

Novel mechanism for age‐related macular degeneration: An equilibrium shift between the angiogenesis factors VEGF and PEDF

2001 • 258 citations

MT1‐MMP expression promotes tumor growth and angiogenesis through an up‐regulation of vascular endothelial growth factor expression

2002 • 254 citations

Unbalanced vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in diabetic retinopathy

2002 • 237 citations

Up-regulation of vascular endothelial growth factor by membrane-type 1 matrix metalloproteinase stimulates human glioma xenograft growth and angiogenesis.

2002 • 157 citations

Human Dermal Microvascular Endothelial Cells Produce Matrix Metalloproteinases in Response to Angiogenic Factors and Migration

1995 • 146 citations

Diminished corneal angiogenesis in gelatinase A‐deficient mice

2001 • 141 citations

Low content of the natural ocular anti-angiogenic agent pigment epithelium-derived factor (PEDF) in aqueous humor predicts progression of diabetic retinopathy

2003 • 140 citations

Pigment epithelium-derived factor in the vitreous is low in diabetic retinopathy and high in rhegmatogenous retinal detachment

2001 • 137 citations

Matrix Metalloproteinase-9-Dependent Exposure of a Cryptic Migratory Control Site in Collagen is Required before Retinal Angiogenesis

2002 • 133 citations

Human diabetic neovascular membranes contain high levels of urokinase and metalloproteinase enzymes.

1999 • 123 citations

Matrix Metalloproteinase-9 Contributes to Choroidal Neovascularization

2002 • 118 citations

Reduced Choroidal Neovascular Membrane Formation in Matrix Metalloproteinase-2–Deficient Mice

2003 • 110 citations

Retinal Neovascularization Is Suppressed With a Matrix Metalloproteinase Inhibitor

1999 • 107 citations

Basic Fibroblast Growth Factor Is Neither Necessary nor Sufficient for the Development of Retinal Neovascularization

1998 • 103 citations

Matrix metalloproteinases and their natural inhibitors in fibrovascular membranes of proliferative diabetic retinopathy

2000 • 99 citations

Difference in Ischemic Regulation of Vascular Endothelial Growth Factor and Pigment Epithelium--Derived Factor in Brown Norway and Sprague Dawley Rats Contributing to Different Susceptibilities to Retinal Neovascularization

2002 • 91 citations

The balance between proteinases and inhibitors in a murine model of proliferative retinopathy.

2001 • 46 citations

ProMMP-9 (92 kDa gelatinase) in vitreous fluid of patients with proliferative diabetic retinopathy

1999 • 44 citations

Shedding Light on Blindness

1995 • 25 citations