Cathepsin B Activity Regulation

[41] Cathepsin B, cathepsin H, and cathepsin L

1981 • 1,678 citations

Glycosaminoglycans: molecular properties, protein interactions, and role in physiological processes

1991 • 1,088 citations

A Self-Consistent Method for the Analysis of Protein Secondary Structure from Circular Dichroism

1993 • 1,032 citations

Proteinases in mammalian cells and tissues

1978 • 981 citations

The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity.

1991 • 595 citations

Proteinases in Mammalian Cells and Tissues

1977 • 537 citations

Heparin-Binding Proteins

1998 • 515 citations

Cell surface heparan sulfate proteoglycans.

1992 • 476 citations

Integral membrane heparan sulfate proteoglycans

1993 • 423 citations

Degradation of extracellular-matrix proteins by human cathepsin B from normal and tumour tissues

1992 • 417 citations

The biology of perlecan: the multifaceted heparan sulphate proteoglycan of basement membranes and pericellular matrices

1994 • 384 citations

Heparan sulfates of cultured cells. I. Membrane-associated and cell-sap species in Chinese hamster cells

1971 • 313 citations

Cysteine proteinases and their endogenous inhibitors: target proteins for prognosis, diagnosis and therapy in cancer (review).

1998 • 278 citations

Mannose-6-phosphate receptors for lysosomal enzymes cycle between the Golgi complex and endosomes.

1986 • 270 citations

Role of the Occluding Loop in Cathepsin B Activity

1997 • 258 citations

Cathepsin B: association with plasma membrane in metastatic tumors.

1986 • 222 citations

Lysosomal enzyme targeting

1990 • 205 citations

Human Procathepsin B Interacts with the Annexin II Tetramer on the Surface of Tumor Cells

2000 • 205 citations

Syndecans, Heparan Sulfate Proteoglycans, Maintain the Proteolytic Balance of Acute Wound Fluids

1998 • 196 citations

Internally quenched fluorogenic protease substrates: Solid-phase synthesis and fluorescence spectroscopy of peptides containing ortho-aminobenzoyl/dinitrophenyl groups as donor-acceptor pairs

1995 • 192 citations

Low Density Lipoprotein Receptor-related Protein/α2-Macroglobulin Receptor Mediates the Cellular Internalization and Degradation of Thrombospondin

1995 • 181 citations

Maturation of human procathepsin B. Proenzyme activation and proteolytic processing of the precursor to the mature proteinase, in vitro, are primarily unimolecular processes.

1994 • 173 citations

Serpins: Structure, Function and Biology

1996 • 168 citations

Major Increase in Endopeptidase Activity of Human Cathepsin B upon Removal of Occluding Loop Contacts

1997 • 160 citations

Proteoglycans synthesized by rat ovarian granulosa cells in culture. Isolation, fractionation, and characterization of proteoglycans associated with the cell layer.

1984 • 159 citations

Function of the syndecans - a family of cell surface proteoglycans

1994 • 153 citations

Exocytosis of active cathepsin B

1999 • 148 citations

Kininogenase Activity by the Major Cysteinyl Proteinase (Cruzipain) from Trypanosoma cruzi

1997 • 130 citations

Heparan sulfate proteoglycan and FGF receptor target basic FGF to different intracellular destinations

1993 • 130 citations

Neither type of mannose 6-phosphate receptor is sufficient for targeting of lysosomal enzymes along intracellular routes.

1996 • 123 citations

A protein engineering study of the role of aspartate 158 in the catalytic mechanism of papain

1990 • 123 citations

Intramolecularly quenched fluorogenic tetrapeptide substrates for tissue and plasma kallikreins

1991 • 121 citations

Structural differences of heparan sulfates according to the tissue and species of origin

1983 • 114 citations

Biosynthesis of cathepsin B in cultured normal and I-cell fibroblasts.

1987 • 104 citations

Characterization of the Heparin Binding Properties of Annexin II Tetramer

1997 • 96 citations

pH-induced Conformational Transitions of the Propeptide of Human Cathepsin L

1998 • 93 citations

Chapter 6 Intracellular proteolysis

1987 • 89 citations

[37] Structure, properties, mechanisms, and assays ofcysteine protease inhibitors: Cystatins and E-64 derivatives

1995 • 86 citations

Interaction of Secretory Leukocyte Protease Inhibitor with Heparin Inhibits Proteases Involved in Asthma

1998 • 85 citations

Human Cathepsin B Is a Metastable Enzyme Stabilized by Specific Ionic Interactions Associated with the Active Site

1994 • 85 citations

Mechanisms of Human Bladder Tumor Invasion: Role of Protease Cathepsin B

1990 • 84 citations

Control of the tissue inhibitor of metalloproteinases-1 promoter in culture-activated rat hepatic stellate cells: Regulation by activator protein-1 DNA binding proteins

1999 • 82 citations

Interrelationship of active and latent secreted human cathepsin B precursors

1986 • 82 citations

Kinetics of proteoheparan sulfate synthesis, secretion, endocytosis, and catabolism by a hepatocyte cell line.

1984 • 81 citations

The Occluding Loop in Cathepsin B Defines the pH Dependence of Inhibition by Its Propeptide

1999 • 68 citations

Structure of heparan sulfate: identification of variable and constant oligosaccharide domains in eight heparan sulfates of different origins.

1998 • 64 citations

Interdependency of Sequence and Positional Specificities for Cysteine Proteases of the Papain Family

1999 • 63 citations

Cysteine Proteinase Activity Regulation

1999 • 58 citations

Heparin protects cathepsin G against inhibition by protein proteinase inhibitors.

1994 • 54 citations

Elevations in Cathepsin B Protein Content and Enzyme Activity Occur Independently of Glycosylation during Colorectal Tumor Progression

1997 • 54 citations

Multiple Proteolytic Action of Rat Liver Cathepsin B: Specificities and pH-Dependences of the Endo- and Exopeptidase Activities1

1991 • 35 citations

Differentiation-induced changes in the content, secretion, and subcellular distribution of lysosomal cathepsins in the human colon cancer HT-29 cell line

1997 • 31 citations

Tumor Cathepsin B and its Endogenous Inhibitors in Metastasis

1988 • 15 citations

Intracellular Proteolysis

2001 • 7 citations