Mechanism by Which Heparin Proteoglycan Modulates Mast Cell Chymase Activity

Proteoglycans: Structures And Interactions

1991 • 1,596 citations

Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart.

1990 • 878 citations

Oligonucleotide inhibitors of human thrombin that bind distinct epitopes

1997 • 804 citations

The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer.

1993 • 449 citations

Minimal sequence in heparin/heparan sulfate required for binding of basic fibroblast growth factor.

1993 • 449 citations

Activation of human interstitial procollagenase through direct cleavage of the Leu83-Thr84 bond by mast cell chymase.

1994 • 320 citations

Role of ternary complexes, in which heparin binds both antithrombin and proteinase, in the acceleration of the reactions between antithrombin and thrombin or factor Xa.

1986 • 254 citations

Cleavage of Type I Procollagen by Human Mast Cell Chymase Initiates Collagen Fibril Formation and Generates a Unique Carboxyl-terminal Propeptide

1997 • 196 citations

Mast cell proteinases activate precursor forms of collagenase and stromelysin, but not of gelatinases A and B

1994 • 186 citations

Secretory Granule Proteases in Rat Mast Cells. Cloning of 10 Different Serine Proteases and a Carboxypeptidase A from Various Rat Mast Cell Populations

1997 • 157 citations

Selective conversion of big endothelins to tracheal smooth muscle-constricting 31-amino acid-length endothelins by chymase from human mast cells.

1997 • 157 citations

Activation of precursors for matrix metalloproteinases 1 (interstitial collagenase) and 3 (stromelysin) by rat mast-cell proteinases I and II

1995 • 93 citations

Regulation and function of mast cell proteases in inflammation.

1998 • 87 citations

Chymase in exocytosed rat mast cell granules effectively proteolyzes apolipoprotein AI-containing lipoproteins, so reducing the cholesterol efflux-inducing ability of serum and aortic intimal fluid.

1996 • 78 citations

Primary structure of a mouse mastocytoma proteoglycan core protein

1989 • 77 citations

Binding properties of IgE receptors on normal mouse mast cells.

1982 • 72 citations

Inhibition of Human Mast Cell Chymase by Secretory Leukocyte Proteinase Inhibitor: Enhancement of the Interaction by Heparin

1996 • 59 citations

Thrombin is inactivated by mast cell secretory granule chymase

1993 • 58 citations

Regulation of Rat Mast Cell Protease 1 Activity

1995 • 58 citations

Monoclonal antibodies specific for oligosaccharides prepared by partial nitrous acid deamination of heparin.

1988 • 50 citations

Interaction of heparin with rat mast cell protease 1.

1994 • 42 citations

Lactoferrin regulates the activity of heparin proteoglycan-bound mast cell chymase: characterization of the binding of heparin to lactoferrin

1996 • 35 citations

Inactivation of thrombin by a complex between rat mast-cell protease 1 and heparin proteoglycan

1994 • 30 citations

Mast cell chymase in complex with heparin proteoglycan is regulated by protamine

1996 • 13 citations

Identification of the Proteolytic Thrombin Fragments Formed after Cleavage with Rat Mast Cell Protease 1

1995 • 8 citations