Activation of Matrix Metalloproteinase-9 (MMP-9) via a Converging Plasmin/Stromelysin-1 Cascade Enhances Tumor Cell Invasion

Matrix metalloproteinases and their inhibitors in connective tissue remodeling

1991 • 3,309 citations

Matrix Metalloproteinases: A Review

1993 • 2,998 citations

A matrix metalloproteinase expressed on the surface of invasive tumour cells

1994 • 2,561 citations

Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase

1995 • 1,576 citations

Tumor Cell Interactions with the Extracellular Matrix During Invasion and Metastasis

1993 • 1,523 citations

The matrix‐degrading metalloproteinases

1992 • 1,383 citations

Biology and biochemistry of proteinases in tumor invasion

1993 • 1,264 citations

SV40-transformed Human Lung Fibroblasts Secrete a 92-kDa Type IV Collagenase Which Is Identical to That Secreted by Normal Human Macrophages

1989 • 1,122 citations

Matrix Metalloproteinase-2 Is an Interstitial Collagenase

1995 • 917 citations

92-kD type IV collagenase mediates invasion of human cytotrophoblasts.

1991 • 722 citations

Multiple modes of activation of latent human fibroblast collagenase: evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation.

1990 • 699 citations

Biochemical and immunological characterization of the secreted forms of human neutrophil gelatinase.

1985 • 625 citations

Furin-dependent intracellular activation of the human stromelysin-3 zymogen

1995 • 620 citations

Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9.

1992 • 620 citations

Tissue cooperation in a proteolytic cascade activating human interstitial collagenase.

1989 • 579 citations

Interaction of 92-kDa type IV collagenase with the tissue inhibitor of metalloproteinases prevents dimerization, complex formation with interstitial collagenase, and activation of the proenzyme with stromelysin.

1992 • 519 citations

Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response.

1996 • 515 citations

Matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) from HT 1080 human fibrosarcoma cells. Purification and activation of the precursor and enzymic properties.

1992 • 502 citations

Requirement for Specific Proteases in Cancer Cell Intravasation as Revealed by a Novel Semiquantitative PCR-Based Assay

1998 • 459 citations

Contributions of tumor and stromal matrix metalloproteinases to tumor progression, invasion and metastasis

1995 • 429 citations

Control of type IV collagenase activity by components of the urokinase-plasmin system: a regulatory mechanism with cell-bound reactants

1997 • 427 citations

Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells.

1994 • 395 citations

Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl)mercuric acetate

1990 • 381 citations

Independent expression and cellular processing of Mr 72,000 type IV collagenase and interstitial collagenase in human tumorigenic cell lines.

1990 • 379 citations

Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2).

1995 • 324 citations

Localization of matrix metalloproteinase 9 (92-kilodalton gelatinase/type IV collagenase = gelatinase B) in osteoclasts: implications for bone resorption.

1995 • 312 citations

The Cell Biology of the Extracellular Matrix

1992 • 305 citations

Expression of matrix metalloproteinase 9 (96‐kd gelatinase B) in human rheumatoid arthritis

1996 • 286 citations

Involvement of PA/plasmin system in the processing of pro‐MMP‐9 and in the second step of pro‐MMP‐2 activation

1997 • 255 citations

Design and characterization of a fluorogenic substrate selectively hydrolyzed by stromelysin 1 (matrix metalloproteinase-3).

1994 • 237 citations

Inhibition of matrix metalloproteinase 9 expression by a ribozyme blocks metastasis in a rat sarcoma model system.

1996 • 217 citations

Activation of Type IV Procollagenases by Human Tumor-associated Trypsin-2

1997 • 217 citations

Metalloproteinases in tumor progression: the contribution of MMP-9.

1994 • 209 citations

Tissue inhibitor of metalloproteinases-2 inhibits the activation of 72 kDa progelatinase by fibroblast membranes

1991 • 201 citations

Tumor and stromal expression of matrix metalloproteinases and their role in tumor progression.

1994 • 200 citations

MMP-2: Expression, Activation and Inhibition

1996 • 195 citations

Constitutive expression of a 92-kD gelatinase (type V collagenase) by rheumatoid synovial fibroblasts and its induction in normal human fibroblasts by inflammatory cytokines.

1991 • 194 citations

Steps Involved in Activation of the Pro-matrix Metalloproteinase 9 (Progelatinase B)-Tissue Inhibitor of Metalloproteinases-1 Complex by 4-Aminophenylmercuric Acetate and Proteinases

1995 • 189 citations

Activation of Progelatinase B (proMMP‐9) by Active Collagenase‐3 (MMP‐13)

1997 • 186 citations

Induction of matrix metalloproteinase activation cascades based on membrane-type 1 matrix metalloproteinase: associated activation of gelatinase A, gelatinase B and collagenase 3

1998 • 180 citations

Glycoprotein, elastin, and collagen secretion by rat smooth muscle cells.

1979 • 174 citations

Epidermal growth factor and amphiregulin up‐regulate matrix metalloproteinase‐9 (MMP‐9) in human breast cancer cells

1997 • 166 citations

Activation of the 92-kDa Gelatinase by Stromelysin and 4-Aminophenylmercuric Acetate

1995 • 166 citations

Dog Mast Cell α-Chymase Activates Progelatinase B by Cleaving the Phe88-Gln89 and Phe91-Glu92 Bonds of the Catalytic Domain

1997 • 158 citations

Analysis of the role of the COOH-terminal domain in the activation, proteolytic activity, and tissue inhibitor of metalloproteinase interactions of gelatinase B.

1994 • 158 citations

Tumor promoter-stimulated Mr 92,000 gelatinase secreted by normal and malignant human cells: isolation and characterization of the enzyme from HT1080 tumor cells.

1990 • 151 citations

Role and regulation of expression of 92‐kDa type‐IV collagenase (MMP‐9) in 2 invasive squamous‐cell‐carcinoma cell lines of the oral cavity

1993 • 123 citations

Melanoma-mediated dissolution of extracellular matrix: contribution of urokinase-dependent and metalloproteinase-dependent proteolytic pathways.

1993 • 106 citations

Activation of the 92 kDa type IV collagenase by tissue kallikrein

1993 • 95 citations

Phorbol ester-induced cell surface association of matrix metalloproteinase-9 in human MCF10A breast epithelial cells.

1997 • 93 citations

Cooperation between Matrix Metalloproteinases and the Plasminogen Activator-Plasmin System in Tumor Progression

1996 • 88 citations

Active and Tissue Inhibitor of Matrix Metalloproteinase-free Gelatinase B Accumulates within Human Microvascular Endothelial Vesicles

1998 • 87 citations

Stromal Cell Expression of Components of Matrix-Degrading Protease Systems in Human Cancer

1996 • 81 citations

Inhibition of Matrix Metalloproteinase 9 Activation by a Specific Monoclonal Antibody

1993 • 70 citations

Activation of gelatinase–tissue-inhibitors-of-metalloproteinase complexes by matrilysin

1998 • 68 citations

Stromelysin-1 (MMP-3)–Independent Gelatinase Expression and Activation in Mice

1998 • 54 citations

Expression of Human Pro-Matrix Metalloproteinase 3 that Lacks the N-terminal 34 Residues in Escherichia coli: Autoactivation and Interaction with Tissue Inhibitor of Metalloproteinase 1 (TIMP-1)

1998 • 50 citations

Properties of radiolabeled type I, II, and III collagens related to their use as substrates in collagenase assays

1986 • 34 citations

Characterization of the 46-kDa Intermediates of Matrix Metalloproteinase 3 (Stromelysin 1) Obtained by Site-directed Mutation of Phenylalanine 83

1996 • 27 citations

The Role of Stromelysin-1 in Stromal-Epithelial Interactions and Cancer

1996 • 21 citations

Introduction of an RRHR motif into chicken urokinase-type plasminogen activator (ch-uPA) confers sensitivity to plasminogen activator inhibitor (PAI)-1 and PAI-2 and allows ch-uPA-mediated extracellular matrix degradation to be controlled by PAI-1

1997 • 18 citations

Cloning, expression, and characterization of chicken tissue inhibitor of metalloproteinase-2 (TIMP-2) in normal and transformed chicken embryo fibroblasts

1998 • 16 citations