Oxidative Cross-linking of Tryptophan to Glycine Restrains Matrix Metalloproteinase Activity

Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability.

1996 • 1,132 citations

S-Nitrosylation of Matrix Metalloproteinases: Signaling Pathway to Neuronal Cell Death

2002 • 943 citations

Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate

2003 • 930 citations

Studies on the chlorinating activity of myeloperoxidase.

1976 • 918 citations

3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima.

1997 • 840 citations

The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis

2001 • 677 citations

Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B

2003 • 627 citations

Hypochlorous Acid Oxygenates the Cysteine Switch Domain of Pro-matrilysin (MMP-7)

2001 • 473 citations

Oxidative Autoactivation of Latent Collagenase by Human Neutrophils

1985 • 466 citations

Matrix metalloproteinases and TIMPs

2000 • 379 citations

Activation of the endogenous metalloproteinase, gelatinase, by triggered human neutrophils.

1986 • 267 citations

Myeloperoxidase

2000 • 261 citations

Comprehensive heterocyclic chemistry : the structure, reactions, synthesis, and uses of heterocyclic compounds

1984 • 245 citations

Leukocytic Oxygen Activation and Microbicidal Oxidative Toxin

1989 • 225 citations

Proteinases in chronic obstructive pulmonary disease

2002 • 192 citations

Hypochlorous Acid Generated by Myeloperoxidase Modifies Adjacent Tryptophan and Glycine Residues in the Catalytic Domain of Matrix Metalloproteinase-7 (Matrilysin)

2003 • 148 citations

Oxidative damage to fibronectin

1991 • 139 citations

Phagocytes Produce 5-Chlorouracil and 5-Bromouracil, Two Mutagenic Products of Myeloperoxidase, in Human Inflammatory Tissue

2003 • 135 citations

Bicarbonate-dependent Peroxidase Activity of Human Cu,Zn-Superoxide Dismutase Induces Covalent Aggregation of Protein

2003 • 108 citations

Generation of Intramolecular and Intermolecular Sulfenamides, Sulfinamides, and Sulfonamides by Hypochlorous Acid: A Potential Pathway for Oxidative Cross-Linking of Low-Density Lipoprotein by Myeloperoxidase

2001 • 101 citations

Vitamin C protects against and reverses specific hypochlorous acid- and chloramine-dependent modifications of low-density lipoprotein

2000 • 97 citations

NMR Identification of Heavy Metal-Binding Sites in a Synthetic Zinc Finger Peptide: Toxicological Implications for the Interactions of Xenobiotic Metals with Zinc Finger Proteins

2001 • 70 citations

Different effects of hypochlorous acid on human neutrophil metalloproteinases: Activation of collagenase and inactivation of collagenase and gelatinase

1992 • 65 citations

Iron Regulatory Protein 2 as Iron Sensor

2003 • 53 citations

Studies of the mechanism of chlorination of indoles. Detection of N-chloroindole and 3-chloro-3H-indole as intermediates

1978 • 41 citations

Oxidation of tryptophan by redox intermediates of myeloperoxidase and inhibition of hypochlorous acid production

2000 • 37 citations

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