Cell Surface Heparan Sulfate Proteoglycans: Selective Regulators of Ligand-Receptor Encounters

Functions of Cell Surface Heparan Sulfate Proteoglycans

1999 • 2,660 citations

Requirement of Heparan Sulfate for bFGF-Mediated Fibroblast Growth and Myoblast Differentiation

1991 • 1,507 citations

Biology of the Syndecans: A Family of Transmembrane Heparan Sulfate Proteoglycans

1992 • 1,095 citations

Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome

1996 • 767 citations

Specificities of heparan sulphate proteoglycans in developmental processes

2000 • 706 citations

Regulated Diversity of Heparan Sulfate

1998 • 671 citations

Membrane protein secretases

1997 • 634 citations

branchless Encodes a Drosophila FGF Homolog That Controls Tracheal Cell Migration and the Pattern of Branching

1996 • 631 citations

CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins

1996 • 534 citations

Heparin-Binding Proteins

1998 • 515 citations

Microbial adherence to and invasion through proteoglycans

1997 • 480 citations

Regulation of growth factor activation by proteoglycans: What is the role of the low affinity receptors?

1995 • 478 citations

Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme

1999 • 478 citations

Cell surface heparan sulfate proteoglycans.

1992 • 476 citations

Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling

1999 • 474 citations

Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase

1998 • 453 citations

The Putative Tumor Suppressors EXT1 and EXT2 Are Glycosyltransferases Required for the Biosynthesis of Heparan Sulfate

1998 • 425 citations

Integral membrane heparan sulfate proteoglycans

1993 • 423 citations

Heparin is essential for the storage of specific granule proteases in mast cells

1999 • 422 citations

breathless, a Drosophila FGF receptor homolog, is essential for migration of tracheal and specific midline glial cells.

1992 • 419 citations

Syntenin, a PDZ protein that binds syndecan cytoplasmic domains

1997 • 413 citations

Shedding of Syndecan-1 and -4 Ectodomains Is Regulated by Multiple Signaling Pathways and Mediated by a Timp-3–Sensitive Metalloproteinase

2000 • 409 citations

Diverse Cell Surface Protein Ectodomains Are Shed by a System Sensitive to Metalloprotease Inhibitors

1996 • 404 citations

The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila

1999 • 393 citations

Regulated Shedding of Syndecan-1 and -4 Ectodomains by Thrombin and Growth Factor Receptor Activation

1997 • 375 citations

Hedgehog Movement Is Regulated through tout velu–Dependent Synthesis of a Heparan Sulfate Proteoglycan

1999 • 367 citations

Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development

1999 • 367 citations

Syndecan-1 is required for Wnt-1-induced mammary tumorigenesis in mice

2000 • 366 citations

Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2

2000 • 350 citations

Direct Interaction of CASK/LIN-2 and Syndecan Heparan Sulfate Proteoglycan and Their Overlapping Distribution in Neuronal Synapses

1998 • 342 citations

Extension and structural variability of the antithrombin-binding sequence in heparin.

1984 • 340 citations

Physiological degradation converts the soluble syndecan-1 ectodomain from an inhibitor to a potent activator of FGF-2

1998 • 339 citations

Syndecan 4 heparan sulfate proteoglycan is a selectively enriched and widespread focal adhesion component.

1994 • 327 citations

Heartless, a Drosophila FGF receptor homolog, is essential for cell migration and establishment of several mesodermal lineages.

1996 • 303 citations

Structural Analysis of Glycosaminoglycans inDrosophila and Caenorhabditis elegans and Demonstration That tout-velu, a Drosophila Gene Related to EXT Tumor Suppressors, Affects Heparan Sulfate in Vivo

2000 • 287 citations

Stimulation of fibroblast growth factor receptor-1 occupancy and signaling by cell surface-associated syndecans and glypican.

1996 • 273 citations

Sequencing Complex Polysaccharides

1999 • 255 citations

Defective Heparan Sulfate Biosynthesis and Neonatal Lethality in Mice LackingN-Deacetylase/N-Sulfotransferase-1

2000 • 239 citations

Cortactin-Src Kinase Signaling Pathway Is Involved in N-syndecan-dependent Neurite Outgrowth

1998 • 229 citations

Loss of cell surface syndecan-1 causes epithelia to transform into anchorage-independent mesenchyme-like cells.

1995 • 221 citations

Spatially Restricted Expression of pipe in the Drosophila Egg Chamber Defines Embryonic Dorsal–Ventral Polarity

1998 • 208 citations

Specific Binding of the Chemokine Platelet Factor 4 to Heparan Sulfate

1997 • 197 citations

Syndecans, Heparan Sulfate Proteoglycans, Maintain the Proteolytic Balance of Acute Wound Fluids

1998 • 196 citations

Cell surface proteoglycan of mouse mammary epithelial cells is shed by cleavage of its matrix-binding ectodomain from its membrane-associated domain.

1987 • 170 citations

Targeted disruption of NDST‐1 gene leads to pulmonary hypoplasia and neonatal respiratory distress in mice

2000 • 166 citations

Syntenin-Syndecan Binding Requires Syndecan-Synteny and the Co-operation of Both PDZ Domains of Syntenin

2000 • 165 citations

Syndecan-1 Shedding Is Enhanced by LasA, a Secreted Virulence Factor of Pseudomonas aeruginosa

2000 • 161 citations

Structural Analysis of Glycosaminoglycans in Animals Bearing Mutations in sugarless, sulfateless, andtout-velu

2000 • 156 citations

Drosophila syndecan: conservation of a cell-surface heparan sulfate proteoglycan.

1994 • 148 citations

Characterization of Heparin and Heparan Sulfate Domains Binding to the Long Splice Variant of Platelet-derived Growth Factor A Chain

1997 • 136 citations

Syndecan-4 Deficiency Impairs Focal Adhesion Formation Only under Restricted Conditions

2000 • 134 citations

Proteoglycans: Master regulators of molecular encounter?

1998 • 113 citations

Oligosaccharide sequences of endothelial cell surface heparan sulfate proteoglycan with affinity for lipoprotein lipase.

1994 • 109 citations

Solid-Phase Oligosaccharide Synthesis: Preparation of Complex Structures Using a Novel Linker and Different Glycosylating Agents

1999 • 105 citations

Syndecans, signaling, and cell adhesion

1996 • 97 citations

In the clutches of proteoglycans: how does heparan sulfate regulate FGF binding?

1995 • 89 citations

Integrin Modulation by Lateral Association

2000 • 84 citations

Suppression of tumor cell growth by syndecan-1 ectodomain.

1994 • 78 citations

Syndesmos, a protein that interacts with the cytoplasmic domain of syndecan-4, mediates cell spreading and actin cytoskeletal organization

2000 • 69 citations

Tyrosine Phosphorylation of Syndecan-1 and -4 Cytoplasmic Domains in Adherent B82 Fibroblasts

1998 • 62 citations

Serine Phosphorylation of Syndecan-2 Proteoglycan Cytoplasmic Domain

1997 • 55 citations

Monomer Complexes of Basic Fibroblast Growth Factor and Heparan Sulfate Oligosaccharides Are the Minimal Functional Unit for Cell Activation

1999 • 50 citations

Similarities and Differences between the Effects of Heparin and Glypican-1 on the Bioactivity of Acidic Fibroblast Growth Factor and the Keratinocyte Growth Factor

1999 • 44 citations

The sugarless mutation affects the expression of the white eye color gene in Drosophila melanogaster

1998 • 13 citations