Negative selection and autoimmunity

NF-κB at the crossroads of life and death

2002 • 2,684 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1996 • 1,902 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis

2001 • 1,672 citations

Positive and Negative Selection of T Cells

2003 • 1,547 citations

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

1999 • 1,500 citations

The Combined Functions of Proapoptotic Bcl-2 Family Members Bak and Bax Are Essential for Normal Development of Multiple Tissues

2000 • 1,427 citations

Positional cloning of the APECED gene

1997 • 1,385 citations

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

1997 • 1,155 citations

The Vβ-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice

1989 • 1,095 citations

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

2001 • 1,043 citations

MATURE T LYMPHOCYTE APOPTOSIS—Immune Regulation in a Dynamic and Unpredictable Antigenic Environment

1999 • 973 citations

Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes

1998 • 843 citations

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

2001 • 815 citations

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family

1995 • 810 citations

Expression of relB is required for the development of thymic medulla and dendritic cells

1995 • 794 citations

Aire regulates negative selection of organ-specific T cells

2003 • 789 citations

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

2002 • 772 citations

Positive and negative selection of an antigen receptor on T cells in transgenic mice

1988 • 758 citations

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

1994 • 708 citations

Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice

1997 • 603 citations

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

2001 • 575 citations

Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas

1994 • 571 citations

Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate–early gene nur77

1994 • 551 citations

A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

1998 • 504 citations

Bcl-2 Can Rescue T Lymphocyte Development in Interleukin-7 Receptor–Deficient Mice but Not in Mutant rag-1 −/− Mice

1997 • 503 citations

Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity

2003 • 467 citations

The Bax Subfamily of Bcl2-Related Proteins Is Essential for Apoptotic Signal Transduction by c-Jun NH₂-Terminal Kinase

2002 • 463 citations

Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

2002 • 463 citations

Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex

1996 • 378 citations

Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL−/− mice

2003 • 345 citations

Protein Kinase B Regulates T Lymphocyte Survival, Nuclear Factor κb Activation, and Bcl-XL Levels in Vivo

2000 • 339 citations

Impaired Negative Selection of T Cells in Hodgkin's Disease Antigen CD30–Deficient Mice

1996 • 316 citations

The generation and fate of thymocytes.

1990 • 309 citations

A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection

1995 • 305 citations

Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis

2002 • 293 citations

Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade

2001 • 276 citations

A defect in central tolerance in NOD mice

2001 • 272 citations

The PI‐3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP₃

2003 • 264 citations

Lower receptor avidity required for thymic clonal deletion than for effector T-cell function

1991 • 263 citations

Signaling Life and Death in the Thymus: Timing Is Everything

2003 • 255 citations

A Role for FADD in T Cell Activation and Development

1998 • 241 citations

T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus.

1994 • 223 citations

The JNK Pathway Regulates the In Vivo Deletion of Immature CD4+CD8+ Thymocytes

1998 • 221 citations

Thymocyte Selection Is Regulated by the Helix-Loop-Helix Inhibitor Protein, Id3

2000 • 220 citations

Differential Roles of ERK and p38 MAP Kinase Pathways in Positive and Negative Selection of T Lymphocytes

1998 • 217 citations

Distinct Roles of the Phosphatidylinositol 3-Kinase and STAT5 Pathways in IL-7-Mediated Development of Human Thymocyte Precursors

1999 • 205 citations

A motif in the αβ T-cell receptor controls positive selection by modulating ERK activity

2000 • 203 citations

HDAC7, a Thymus-Specific Class II Histone Deacetylase, Regulates Nur77 Transcription and TCR-Mediated Apoptosis

2003 • 198 citations

Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance

1997 • 183 citations

Bax alpha perturbs T cell development and affects cell cycle entry of T cells.

1996 • 170 citations

A Role for Fas in Negative Selection of Thymocytes In Vivo

1998 • 167 citations

Disruption of T cell signaling networks and development by Grb2 haploid insufficiency

2001 • 165 citations

Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells.

1996 • 161 citations

Receptor editing in developing T cells

2000 • 157 citations

Gene defect behind APECED: a new clue to autoimmunity

1998 • 154 citations

An essential role for gp39, the ligand for CD40, in thymic selection.

1995 • 148 citations

T-cell signalling and autoimmunity: molecular mechanisms of disease

2002 • 144 citations

Failure to Censor Forbidden Clones of CD4 T Cells in Autoimmune Diabetes

2002 • 140 citations

In Vitro Evidence That Cytokine Receptor Signals Are Required for Differentiation of Double Positive Thymocytes into Functionally Mature CD8+ T Cells

2003 • 137 citations

Distinct sequence of negative or positive selection implied by thymocyte T-cell receptor densities

1990 • 136 citations

Thymocyte Apoptosis Induced by T Cell Activation Is Mediated by Glucocorticoids In Vivo

2002 • 129 citations

The role of cytokine receptor signaling in lymphocyte development

1999 • 118 citations

Peptide-Induced Negative Selection of Thymocytes Activates Transcription of an NF-ΚB Inhibitor

2002 • 117 citations

DR3 Regulates Negative Selection during Thymocyte Development

2001 • 114 citations

Differential involvement of p38 mitogen‐activated protein kinase kinases MKK3 and MKK6 in T‐cell apoptosis

2002 • 110 citations

Duration and Strength of Extracellular Signal-Regulated Kinase Signals Are Altered During Positive Versus Negative Thymocyte Selection

2001 • 110 citations

APECED: a monogenic autoimmune disease providing new clues to self-tolerance

1998 • 99 citations

Abnormal thymocyte development and production of autoreactive T cells in T cell receptor transgenic autoimmune mice.

1991 • 97 citations

Bax Deficiency Partially Corrects Interleukin-7 Receptor α Deficiency

2002 • 95 citations

Specific Activation of the Cysteine Protease CPP32 during the Negative Selection of T Cells in the Thymus

1997 • 92 citations

TNF Receptor-Deficient Mice Reveal Striking Differences Between Several Models of Thymocyte Negative Selection

1998 • 84 citations

A Role for the B7-1/B7-2:CD28/CTLA-4 Pathway During Negative Selection

2003 • 83 citations

Caspase Enzyme Activity Is Not Essential for Apoptosis During Thymocyte Development

2000 • 79 citations

The Critical Role of LIGHT, a TNF Family Member, in T Cell Development

2001 • 77 citations

Tolerogenicity of thymic epithelium

1990 • 74 citations

Normal Thymocyte Negative Selection in TRAIL-deficient Mice

2003 • 72 citations

Failure of HY-Specific Thymocytes to Escape Negative Selection by Receptor Editing

2002 • 71 citations

Blocked negative selection of developing T cells in mice expressing the baculovirus p35 caspase inhibitor

1999 • 70 citations

Crucial Role of Jak3 in Negative Selection of Self-reactive T Cells

1997 • 69 citations

Clonal deletion induced by either radioresistant thymic host cells or lymphohemopoietic donor cells at different stages of class I-restricted T cell ontogeny.

1992 • 67 citations

Death and Baxes: mechanisms of lymphotrophic cytokines

2003 • 64 citations

Thymocyte-targeted overexpression of xiap transgene disrupts T lymphoid apoptosis and maturation

2001 • 61 citations

Constitutively Active Protein Kinase B Enhances Lck and Erk Activities and Influences Thymocyte Selection and Activation

2003 • 60 citations

Degree of ERK activation influences both positive and negative thymocyte selection

2000 • 59 citations

Immature CD4+CD8+ Thymocytes Do Not Polarize Lipid Rafts in Response to TCR-Mediated Signals

2000 • 56 citations

MEK Activity Regulates Negative Selection of Immature CD4+CD8+ Thymocytes

2000 • 55 citations

Pre‐TCR signaling regulates IL‐7 receptor α expression promoting thymocyte survival at the transition from the double‐negative to double‐positive stage

2003 • 54 citations

Cross-linking of T-cell receptors on double-positive thymocytes induces a cytokine-mediated stromal activation process linked to cell death.

1996 • 53 citations

A Spontaneous CD8 T Cell-Dependent Autoimmune Disease to an Antigen Expressed Under the Human Keratin 14 Promoter

2002 • 52 citations

The TNF Receptor Family Member CD30 Is Not Essential for Negative Selection

2000 • 50 citations

Cell Death Control in Lymphocytes

2001 • 48 citations

The Apoptotic Protease-Activating Factor 1-Mediated Pathway of Apoptosis Is Dispensable for Negative Selection of Thymocytes

2002 • 48 citations

LIGHT (a Cellular Ligand for Herpes Virus Entry Mediator and Lymphotoxin Receptor)-Mediated Thymocyte Deletion Is Dependent on the Interaction Between TCR and MHC/Self-Peptide

2003 • 30 citations

Role of IL-12 in Intrathymic Negative Selection

1999 • 26 citations

The transcriptional regulator Rel is essential for antigen receptor-mediated stimulation of mature T cells but dispensable for positive and negative selection of thymocytes and T cell apoptosis

1999 • 23 citations

RelB reduces thymocyte apoptosis and regulates terminal thymocyte maturation

2002 • 22 citations

Infrared observations of SS433

1979 • 13 citations

Different Role of Apaf‐1 in Positive Selection, Negative Selection and Death by Neglect in Foetal Thymic Organ Culture

2002 • 9 citations