The Bax Subfamily of Bcl2-Related Proteins Is Essential for Apoptotic Signal Transduction by c-Jun NH₂-Terminal Kinase

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Cellular survival: a play in three Akts

1999 • 4,229 citations

Signal Transduction by the JNK Group of MAP Kinases

2000 • 4,096 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

BCL-2 family members and the mitochondria in apoptosis

1999 • 3,657 citations

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

2000 • 3,415 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

2000 • 2,344 citations

Endonuclease G is an apoptotic DNase when released from mitochondria

2001 • 1,725 citations

Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway

2000 • 1,703 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

The JNK signal transduction pathway

2002 • 1,520 citations

Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway

1995 • 1,453 citations

The Combined Functions of Proapoptotic Bcl-2 Family Members Bak and Bax Are Essential for Normal Development of Multiple Tissues

2000 • 1,427 citations

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

Selective interaction of JNK protein kinase isoforms with transcription factors.

1996 • 1,333 citations

MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway

1996 • 1,286 citations

Bid-induced Conformational Change of Bax Is Responsible for Mitochondrial Cytochrome c Release during Apoptosis

1999 • 1,255 citations

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

2000 • 1,245 citations

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

1997 • 1,229 citations

A Serine Protease, HtrA2, Is Released from the Mitochondria and Interacts with XIAP, Inducing Cell Death

2001 • 1,106 citations

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

1999 • 999 citations

BCL-2 Is Phosphorylated and Inactivated by an ASK1/Jun N-Terminal Protein Kinase Pathway Normally Activated at G₂/M

1999 • 997 citations

The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development

1999 • 888 citations

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

2001 • 815 citations

Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2

1995 • 775 citations

Identification of Omi/HtrA2 as a Mitochondrial Apoptotic Serine Protease That Disrupts Inhibitor of Apoptosis Protein-Caspase Interaction

2002 • 732 citations

A Cytoplasmic Inhibitor of the JNK Signal Transduction Pathway

1997 • 678 citations

Nonionic Detergents Induce Dimerization among Members of the Bcl-2 Family

1997 • 583 citations

Dominant-Negative c-Jun Promotes Neuronal Survival by Reducing BIM Expression and Inhibiting Mitochondrial Cytochrome c Release

2001 • 568 citations

Posttranslational N-Myristoylation of BID as a Molecular Switch for Targeting Mitochondria and Apoptosis

2000 • 555 citations

HtrA2 Promotes Cell Death through Its Serine Protease Activity and Its Ability to Antagonize Inhibitor of Apoptosis Proteins

2002 • 550 citations

Bcl-2 Phosphorylation Required for Anti-apoptosis Function

1997 • 540 citations

The Serine Protease Omi/HtrA2 Regulates Apoptosis by Binding XIAP through a Reaper-like Motif

2002 • 533 citations

ATF-2 contains a phosphorylation-dependent transcriptional activation domain.

1995 • 504 citations

Cytochrome c Deficiency Causes Embryonic Lethality and Attenuates Stress-Induced Apoptosis

2000 • 501 citations

Induction of BIM, a Proapoptotic BH3-Only BCL-2 Family Member, Is Critical for Neuronal Apoptosis

2001 • 453 citations

Phosphorylation of Bcl2 and regulation of apoptosis

2001 • 453 citations

Translocation of SAPK/JNK to Mitochondria and Interaction with Bcl-xL in Response to DNA Damage

2000 • 421 citations

Mitochondrial endonuclease G is important for apoptosis in C. elegans

2001 • 416 citations

Bcl-2 Undergoes Phosphorylation by c-Jun N-terminal Kinase/Stress-activated Protein Kinases in the Presence of the Constitutively Active GTP-binding Protein Rac1

1997 • 406 citations

Bax Deletion Further Orders the Cell Death Pathway in Cerebellar Granule Cells and Suggests a Caspase-independent Pathway to Cell Death

1997 • 390 citations

Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH ₂ -terminal kinase

1997 • 382 citations

Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2

1999 • 357 citations

MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines

2001 • 349 citations

The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity

2002 • 349 citations

Direct Activation of Mitochondrial Apoptosis Machinery by c-Jun N-terminal Kinase in Adult Cardiac Myocytes

2002 • 342 citations

Posttranslational Modification of Bcl-2 Facilitates Its Proteasome-Dependent Degradation: Molecular Characterization of the Involved Signaling Pathway

2000 • 315 citations

A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation

1998 • 311 citations

Dephosphorylation Targets Bcl-2 for Ubiquitin-dependent Degradation: A Link between the Apoptosome and the Proteasome Pathway

1999 • 309 citations

JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development

1999 • 305 citations

Vinblastine-induced Phosphorylation of Bcl-2 and Bcl-XL Is Mediated by JNK and Occurs in Parallel with Inactivation of the Raf-1/MEK/ERK Cascade

2000 • 291 citations

Novel Role for JNK as a Stress-activated Bcl2 Kinase

2001 • 290 citations

A novel SAPK/JNK kinase, MKK7, stimulated by TNFalpha and cellular stresses

1997 • 258 citations

The c-Jun N-Terminal Kinase Cascade Plays a Role in Stress-Induced Apoptosis in Jurkat Cells by Up-Regulating Fas Ligand Expression

1998 • 238 citations

C-Jun Nh2-Terminal Kinase (Jnk)1 and Jnk2 Have Similar and Stage-Dependent Roles in Regulating T Cell Apoptosis and Proliferation

2001 • 219 citations

Stress-Induced Fas Ligand Expression in T Cells Is Mediated through a MEK Kinase 1-Regulated Response Element in the Fas Ligand Promoter

1998 • 193 citations

MKK7 Is A Stress-activated Mitogen-activated Protein Kinase Kinase Functionally Related to hemipterous

1997 • 182 citations

The MKK7 Gene Encodes a Group of c-Jun NH₂-Terminal Kinase Kinases

1999 • 169 citations

Induction of Mitogen-activated Protein Kinase Phosphatase 1 by the Stress-activated Protein Kinase Signaling Pathway but Not by Extracellular Signal-regulated Kinase in Fibroblasts

1996 • 162 citations

Bcl-xL Functions Downstream of Caspase-8 to Inhibit Fas- and Tumor Necrosis Factor Receptor 1-induced Apoptosis of MCF7 Breast Carcinoma Cells

1998 • 160 citations

Signal transduction by MAP kinases in T lymphocytes

2001 • 117 citations

The JNKK2-JNK1 Fusion Protein Acts As a Constitutively Active c-Jun Kinase That Stimulates c-Jun Transcription Activity

1999 • 110 citations

Molecular Cloning and Characterization of Human JNKK2, a Novel Jun NH₂-Terminal Kinase-Specific Kinase

1997 • 108 citations

Activation of Stress-activated Protein Kinases/c-Jun N-terminal Protein Kinases (SAPKs/JNKs) by a Novel Mitogen-activated Protein Kinase Kinase (MKK7)

1997 • 100 citations

Regulation of Protein Kinase B

1999 • 86 citations

Cell cycle regulation of the c-Myc transcriptional activation domain.

1993 • 71 citations