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Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

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Cancer: Principles and Practice of Oncology

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5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes

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Genetic studies of the lac repressor

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MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas

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hMLH1 Promoter Hypermethylation Is an Early Event in Human Endometrial Tumorigenesis

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The Prevention of Thymic Lymphomas in Transgenic Mice by Human O ⁶ -Alkylguanine-DNA Alkyltransferase

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Promoter methylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G:C -> A:T mutations of the TP53 tumor suppressor gene

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1996 • 215 citations

Methylation of Discrete Regions of the O⁶-Methylguanine DNA Methyltransferase (MGMT) CpG Island Is Associated with Heterochromatinization of the MGMT Transcription Start Site and Silencing of the Gene

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p53 mutational spectra and the role of methylated CpG sequences

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Aberrant CpG Island Methylation of Multiple Genes in Intrahepatic Cholangiocarcinoma

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Characterization of the promoter region of the human O⁶-methylguanine-DNA methyltransferase gene

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The impact of chromatin in human cancer: linking DNA methylation to gene silencing

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Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes

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Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon

1995 • 130 citations

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Improvement of chemotherapy efficacy by inactivation of a DNA-repair pathway

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Methylation ofO6-methylguanine-DNA methyltransferase gene is associated significantly withK-ras mutation, lymph node invasion, tumor staging, and disease free survival in patients with gastric carcinoma

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Methylation of CpG Island Transcription Factor Binding Sites Is Unnecessary for Aberrant Silencing of the Human MGMT Gene

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Inactivation of the DNA repair gene O⁶‐methylguanine‐DNA methyltransferase by promoter hypermethylation and its relationship to aflatoxin B₁‐DNA adducts and p53 mutation in hepatocellular carcinoma

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The DNA repair protein, O6-Methylguanine-DNA methyltransferase is a proteolytic target for the E6 human papillomavirus oncoprotein

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A specific CpG methylation pattern of theMGMT promoter region associated with reduced MGMT expression in primary colorectal cancers

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Comparison of O-6-MethyIguanine DNA Methyltransferase (MGMT) mRNA Levels in Mer⁺ and Mer⁻ Human Tumor Cell Lines Containing the MGMT Gene by the Polymerase Chain Reaction Technique

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Frequent promoter hypermethylation of the O6-Methylguanine-DNA Methyltransferase (MGMT) gene in testicular cancer

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A polymorphism at codon 160 of human O⁶ methylguanine-DNA methyltransferase gene in young patients with adult type cancers and functional assay

1995 • 69 citations

Enzymatic methylation of cytosine in DNA is prevented by adjacent O6-methylguanine residues

1991 • 59 citations

Methylation of selected CpGs in the humanO6-methylguanine-DNA methyltransferase promoter region as a marker of gene silencing

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Aberrant Silencing of the CpG Island-Containing Human O⁶-Methylguanine DNA Methyltransferase Gene Is Associated with the Loss of Nucleosome-Like Positioning

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Novel O⁶-methylguanine-DNA methyltransferase SNPs: A frequency comparison of patients with familial melanoma and healthy individuals in Sweden

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Modulation of cyclophosphamide activity by O ? 6 -alkylguanine-DNA alkyltransferase

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Molecular diagnostics of cancer predisposition: hereditary non-polyposis colorectal carcinoma and mismatch repair defects

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Protein phosphorylation is a regulatory mechanism for O6-alkylguanine-DNA alkyltransferase in human brain tumor cells.

2000 • 52 citations

Characterization of human polymorphic DNA repair methyltransferase

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Deficient expression ofO 6-Methylguanine-DNA methyltransferase combined with mismatch-repair proteins hMLH1 and hMSH2 is related to poor prognosis in human biliary tract carcinoma

2002 • 51 citations

DNA repair gene O6-methylguanine-DNA methyltransferase: Promoter hypermethylation associated with decreased expression and G:C to A:T mutations ofp53 in brain tumors

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Mutations ofO6-methylguanine-DNA methyltransferase gene in esophageal cancer tissues from Northern China

1997 • 49 citations

O6-methylguanine-DNA methyltransferase activity and sensitivity to cyclophosphamide and cisplatin in human lung tumor xenografts

1998 • 46 citations

Fast repair of O ⁶ -ethylguanine, but not O ⁶ -methylguanine, in transcribed genes prevents mutation of H- ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea

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A defect in a single allele of the Mlh1 gene causes dissociation of the killing and tumorigenic actions of an alkylating carcinogen in methyltransferase-deficient mice

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Detection of Messenger RNA From O6-Methylguanine-DNA Methyltransferase Gene MGMT in Human Normal and Tumor Tissues

1992 • 43 citations

Molecular Epidemiology of Human Cancer

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The role of mRNA stability and transcription in 0⁶-methylguanine DNA methyltransferase (MGMT) expression in Mer⁺ human tumor cells

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Chinese hamster cells harbouring the Escherichia coli O⁶-alkylguanine alkyltransferase gene are less susceptible to sister chromatid exchange induction and chromosome damage by methylating agents

1986 • 30 citations

Inactivation of O⁶‐Methylguanine‐DNA Methyltransferase in Human Lung Adenocarcinoma Relates to High‐grade Histology and Worse Prognosis among Smokers

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Novel genetic polymorphisms in DNA repair genes: O6-methylguanine-DNA methyltransferase (MGMT) andN-methylpurine-DNA glycosylase (MPG) in lung cancer patients from Poland

1999 • 26 citations

O⁶-methylguanine inibits the binding of transcription factors to DNA

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O6-Methylguanine in DNA inhibits replication in vitro by human cell extracts

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Regulatory issues in the evaluation of antimetastatic and other novel anticancer therapies

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Elbow-room for consequentialists

1992 • 3 citations