Frequent promoter hypermethylation of the O6-Methylguanine-DNA Methyltransferase (MGMT) gene in testicular cancer

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

1996 • 5,667 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

Inactivation of the DNA-Repair GeneMGMTand the Clinical Response of Gliomas to Alkylating Agents

2000 • 2,127 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

1994 • 1,806 citations

DNA hypermethylation in tumorigenesis: epigenetics joins genetics

2000 • 1,628 citations

Aberrant CpG-island methylation has non-random and tumour-type–specific patterns

2000 • 1,344 citations

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.

1999 • 1,252 citations

Structure, Function, and Inhibition of O6-Alkylguanine-DNA Alkyltransferase

1995 • 502 citations

Chromosomal imbalance maps of malignant solid tumors: a cytogenetic survey of 3185 neoplasms.

1997 • 434 citations

Epigenetic lesions causing genetic lesions in human cancer

2000 • 256 citations

Promoter methylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G:C -> A:T mutations of the TP53 tumor suppressor gene

2001 • 231 citations

Ploidy of primary germ cell tumors of the testis. Pathogenetic and clinical relevance.

1989 • 217 citations

Methylation hot spots in the 5' flanking region denote silencing of the O6-methylguanine-DNA methyltransferase gene.

1997 • 214 citations

Graded methylation in the promoter and body of the O6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells.

1994 • 200 citations

Distinct epigenetic phenotypes in seminomatous and nonseminomatous testicular germ cell tumors

2002 • 165 citations

Correlation of p16 Hypermethylation with p16 Protein Loss in Sporadic Gastric Carcinomas

2000 • 137 citations

Advances in Cancer Research

1960 • 118 citations

Susceptibility to testicular germ-cell tumours in a 129.MOLF-Chr 19 chromosome substitution strain

1999 • 100 citations

Genome profiles of familial/bilateral and sporadic testicular germ cell tumors

2002 • 82 citations

Epigenetic regulation of the MGMT and hMSH6 DNA repair genes in cells resistant to methylating agents.

2000 • 81 citations

A New Tool for the Rapid Cloning of Amplified and Hypermethylated Human DNA Sequences from Restriction Landmark Genome Scanning Gels

1999 • 79 citations

Protective effect of O6-methylguanine-DNA methyltransferase (MGMT) on the cytotoxic and recombinogenic activity of different antineoplastic drugs

1996 • 75 citations

Evaluation of loss of heterozygosity/allelic imbalance scoring in tumor DNA

2001 • 73 citations

A genetic perspective of male germ cell tumors.

1998 • 62 citations

Methylation of selected CpGs in the humanO6-methylguanine-DNA methyltransferase promoter region as a marker of gene silencing

1999 • 59 citations

Allelic losses in carcinoma in situ and testicular germ cell tumours of adolescents and adults: evidence suggestive of the linear progression model

2000 • 53 citations

Localization of methylation sites in the human O⁶-methylguanine-DNA methyltransferase promoter: correlation with gene suppression

1995 • 53 citations

Identification of a 59 bp enhancer located at the first exon/intron boundary of the human O⁶-methylguanine DNA methyltransferease gene

1994 • 46 citations

A molecular model for the development of germ cell cancer

1999 • 45 citations

Frequent loss of 11p13 and 11p15 loci in male germ cell tumours

1993 • 39 citations

Salvage treatment in male patients with germ cell tumours

1993 • 37 citations

Familial/Bilateral and Sporadic Testicular Germ Cell Tumors Show Frequent Genetic Changes at Loci with Suggestive Linkage Evidence

2001 • 34 citations

Molecular Genetic Parameters in Pathogenesis and Prognosis of Testicular Germ Cell Tumors

2000 • 29 citations

MOLECULAR ANALYSIS OF P16 ^Ink4 /CDKN2 AND P15 ^Ink4B /MTS2 GENES IN PRIMARY HUMAN TESTICULAR GERM CELL TUMORS

1998 • 29 citations

De la charte du bassin parisien vers un établissement public

1998 • 3 citations