Fast repair of O ⁶ -ethylguanine, but not O ⁶ -methylguanine, in transcribed genes prevents mutation of H- ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 2,165 citations

Preferential Formation of Benzo[ a ]pyrene Adducts at Lung Cancer Mutational Hotspots in P53

1996 • 1,636 citations

Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene

1987 • 1,235 citations

DNA repair in an active gene: Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall

1985 • 1,233 citations

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease.

1992 • 1,190 citations

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185

1986 • 1,020 citations

Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents

1990 • 880 citations

Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats

1985 • 829 citations

REGULATION AND EXPRESSION OF THE ADAPTIVE RESPONSE TO ALKYLATING AGENTS

1988 • 645 citations

Persistence of O 6-Ethylguanine in Rat-Brain DNA: Correlation with Nervous System-Specific Carcinogenesis by Ethylnitrosourea

1974 • 495 citations

<italic>N</italic>-Nitrosomethylurea as Mammary Gland Carcinogen in Rats

1975 • 354 citations

Comparison of O⁶-alkylguanine-DNA alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues

1986 • 277 citations

Activation of ras Oncogenes Preceding the Onset of Neoplasia

1990 • 261 citations

The Prevention of Thymic Lymphomas in Transgenic Mice by Human O ⁶ -Alkylguanine-DNA Alkyltransferase

1993 • 238 citations

Influence of differentiation and cell kinetics on the susceptibility of the rat mammary gland to carcinogenesis.

1980 • 237 citations

Active site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesis.

1985 • 221 citations

Deficient DNA repair capacity, a predisposing factor in breast cancer

1996 • 198 citations

Molecular cloning and characterization of a gene coding for methanol oxidase inHansenula polymorpha

1985 • 191 citations

Mechanism of inactivation of human O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine

1993 • 152 citations

O6-methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis.

1993 • 143 citations

N-nitroso-N-methylurea-induced rat mammary tumors arise from cells with preexisting oncogenic Hras1 gene mutations.

1994 • 141 citations

Alternative pathways for the in vivo repair of O6-alkylguanine and O4-alkylthymine in Escherichia coli: the adaptive response and nucleotide excision repair.

1988 • 139 citations

Efficient repair of O6-ethylguanine, but not O4-ethylthymine or O2-ethylthymine, is dependent upon O6-alkylguanine-DNA alkyltransferase and nucleotide excision repair activities in human cells.

1992 • 135 citations

Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon

1995 • 130 citations

NDF/heregulin induces persistence of terminal end buds and adenocarcinomas in the mammary glands of transgenic mice.

1996 • 123 citations

DNA repair domains within a human gene: selective repair of sequences near the transcription initiation site.

1996 • 116 citations

Activated neu oncogene sequences in primary tumors of the peripheral nervous system induced in rats by transplacental exposure to ethylnitrosourea.

1987 • 107 citations

Removal of O6-methylguanine from DNA by human liver fractions.

1982 • 102 citations

Double Mutants of Saccharomyces cerevisiae with Alterations in Global Genome and Transcription-Coupled Repair

1996 • 97 citations

Targeted expression of human O(6)-methylguanine-DNA methyltransferase (MGMT) in transgenic mice protects against tumor initiation in two-stage skin carcinogenesis.

1996 • 86 citations

Early mutation of the neu (erbB-2) gene during ethylnitrosourea-induced oncogenesis in the rat Schwann cell lineage.

1991 • 86 citations

Repair of O⁶-propylguanine and O⁶-butylguanine in DNA by O⁶-alkylguanine-DNA alkyltransferases from rat liver and E. coli

1985 • 80 citations

Relevance Of Animal Studies To The Evaluation Of Human Cancer Risk

1992 • 79 citations

Nucleotide sequence of the two rat cellular rasH genes.

1986 • 75 citations

DNA excision repair profiles of normal and leukemic human lymphocytes: functional analysis at the single-cell level.

1997 • 72 citations

Somatic mutation theory, DNA repair rates, and the molecular epidemiology of p53 mutations

1997 • 65 citations

Molecular analysis of hprt gene mutations in skin fibroblasts of rats exposed in vivo to N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea.

1994 • 61 citations

Structure of the c-Ki-ras Gene in a Rat Fibrosarcoma Induced by 1,8-Dinitropyrene

1986 • 53 citations

Repair of O6-ethylguanine in DNA protects rat 208F cells from tumorigenic conversion by N-ethyl-N-nitrosourea.

1990 • 46 citations

DNA methyl-adduct dosimetry and O⁶-alkylguanine-DNA alkyl transferase activity determinations in rat mammary carcinogenesis by procarbazine and N-methylnitrosourea

1990 • 45 citations

Immunological Detection and Quantification of DNA Components Structurally Modified by Alkylating Carcinogens (Ethylnitrosourea)

1980 • 44 citations

Differential formation and repair of the mutagenic DNA alkylation product O6-ethylguanine in transcribed and nontranscribed genes of the rat.

1994 • 42 citations

Alkylation damage, DNA repair and mutagenesis in human cells

1990 • 39 citations

Binding and repair of O6-ethylguanine in double-stranded oligodeoxynucleotides by recombinant human O6-alkylguanine-DNA alkyltransferase do not exhibit significant dependence on sequence context

1996 • 35 citations

Incidence of c-Ki-ras activation in N-methyl-N-nitrosourea-induced mammary carcinomas in pituitary-isografted mice.

1992 • 35 citations

Specificities of human, rat andE.coliO⁶-methylguanine-DNA methyltransferases towards the repair of O⁶-methyl and O⁶-ethylguanine in DNA

1994 • 32 citations

Characterization of N-ethyl-N-nitrosourea--induced mammary tumors in the rat.

1983 • 26 citations

Infrequent Ha‐ras mutations and absence of Ki‐ras, N‐ras, and p53 mutations in 4‐nitroquinoline 1‐oxide‐induced rat oral lesions

1995 • 25 citations

Wild type neu transgene counteracts mutant homologue in malignant transformation of rat Schwann cells.

1996 • 19 citations

N-Ethyl-N-nitrosourea induces mammary cancers in the pituitary-isografted mouse which are histologically and genotypically distinct from those induced by N-methyl-N-nitrosourea

1996 • 16 citations

Formation and repair of O6-methylguanine and methylation of the Ha-ras proto-oncogene by N-methyl-N-nitrosourea are not associated with mammary tumor resistance in the Copenhagen rat

1992 • 16 citations

Cellular kinetics of rat mammary gland terminal end bud epithelium exposed to N-methyl-N-nitrosourea in vivo.

1992 • 15 citations

Monoclonal Antibody-Based Quantification and Repair Analysis of Specific Alkylation Products in DNA

1996 • 11 citations

Preferential methylation of the Ha‐ras proto‐oncogene by methylnitrosourea in rat mammary glands

1991 • 10 citations

Formation and persistence of O⁶-ethylguanine in genomic and transgene DNA in liver and brain of λlacZ transgenic mice treated with N-ethyl-N-nitrosourea

1996 • 10 citations

Effect of O⁶-methylguanine-DNA methytransferase gene activity on repair in human cells transformed by a regulatabile ada gene

1990 • 8 citations

Nucleotide Sequence of the Two Rat Cellular ras^H Genes

1986 • 1 citations