A specific CpG methylation pattern of theMGMT promoter region associated with reduced MGMT expression in primary colorectal cancers

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

Lessons from Hereditary Colorectal Cancer

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Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers

1990 • 1,747 citations

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

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The APC gene product in normal and tumor cells.

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Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains

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Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage

1993 • 361 citations

DNA damage tolerance, mismatch repair and genome instability

1994 • 308 citations

Methylation hot spots in the 5' flanking region denote silencing of the O6-methylguanine-DNA methyltransferase gene.

1997 • 214 citations

A Pseudoautosomal Gene in Man

1986 • 210 citations

Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation by methylnitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine.

1986 • 203 citations

Graded methylation in the promoter and body of the O6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells.

1994 • 200 citations

In vivo evidence for endogenous DNA alkylation damage as a source of spontaneous mutation in eukaryotic cells.

1993 • 177 citations

DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypes in human colorectal carcinoma cell lines.

1995 • 168 citations

Characterization of the promoter region of the human O⁶-methylguanine-DNA methyltransferase gene

1991 • 142 citations

cDNA cloning and chromosomal assignment of the human O6-methylguanine-DNA methyltransferase. cDNA expression in Escherichia coli and gene expression in human cells.

1990 • 113 citations

Wild-type p53 suppresses transcription of the human O6-methylguanine-DNA methyltransferase gene.

1996 • 95 citations

Methylation of CpG Island Transcription Factor Binding Sites Is Unnecessary for Aberrant Silencing of the Human MGMT Gene

1996 • 86 citations

Comparison of O-6-MethyIguanine DNA Methyltransferase (MGMT) mRNA Levels in Mer⁺ and Mer⁻ Human Tumor Cell Lines Containing the MGMT Gene by the Polymerase Chain Reaction Technique

1990 • 72 citations

Absence of methylation of a CpG-rich region at the 5' end of the MIC2 gene on the active X, the inactive X, and the Y chromosome.

1988 • 63 citations

Methylation of selected CpGs in the humanO6-methylguanine-DNA methyltransferase promoter region as a marker of gene silencing

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Isolation and purification of O6-Alkylguanine-DNA alkyltransferase from human leukemic cells. Prevention of chloroethylnitrosourea-induced cross-links by purified enzyme

1985 • 59 citations

Direct Correlation Between Methylation Status and Expression of the Human O-6-MethyIguanine DNA Methyltransferase Gene

1991 • 58 citations

Mutations inMLH1 are more frequent than inMSH2 in sporadic colorectal cancers with microsatellite instability

1997 • 54 citations

Localization of methylation sites in the human O⁶-methylguanine-DNA methyltransferase promoter: correlation with gene suppression

1995 • 53 citations

Correlation between DNA methylation and expression of O6-methylguanine-DNA methyltransferase gene in cultured human tumor cells

1992 • 45 citations

Detection of Messenger RNA From O6-Methylguanine-DNA Methyltransferase Gene MGMT in Human Normal and Tumor Tissues

1992 • 43 citations

A mutator phenotype characterizes one of two complementation groups in human cells tolerant to methylation damage.

1995 • 38 citations

Mutagenesis of codon 248 of the human p53 tumor suppressor gene by N-ethyl-N-nitrosourea.

1994 • 36 citations

Cytosine methylation and suppression of O6-methylguanine-DNA methyltransferase expression in human rhabdomyosarcoma cell lines and xenografts.

1992 • 31 citations

In vitro methylation of the human O6-methylguanine-DNA methyltransferase promoter reduces transcription

1994 • 31 citations

N-Nitroso bile acid conjugates. 1. Synthesis, chemical reactivity and mutagenic activity

1981 • 31 citations

Expression of O6-methylguanine-DNA methyltransferase in six human medulloblastoma cell lines.

1992 • 30 citations

DNA mismatch repair mutants do not increase N-methyl-N'-nitro- N-nitrosoguanidine tolerance in O⁶-methylguanine DNA methyltransferase-deficient yeast cells

1995 • 24 citations

Immunohistochemical study of colorectal adenocarcinomas and adenomas with antibodies against carcinoembryonic antigen (CEA), CA19-9, keratin, α-tubulin and secretory component (SC)

1991 • 10 citations

Four new mutations in the DNA mismatch repair gene MLH1 in colorectal cancers with microsatellite instability

1998 • 3 citations