The Prevention of Thymic Lymphomas in Transgenic Mice by Human O ⁶ -Alkylguanine-DNA Alkyltransferase

Mutator phenotype may be required for multistage carcinogenesis.

1991 • 1,327 citations

Cell Proliferation in Carcinogenesis

1990 • 1,063 citations

Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats

1985 • 829 citations

Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.

1990 • 736 citations

Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.

1990 • 460 citations

The origins of human cancer: molecular mechanisms of carcinogenesis and their implications for cancer prevention and treatment--twenty-seventh G.H.A. Clowes memorial award lecture.

1988 • 326 citations

Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanine.

1990 • 292 citations

Comparison of O⁶-alkylguanine-DNA alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues

1986 • 277 citations

N-nitroso alkylating agents: formation and persistence of alkyl derivatives in mammalian nucleic acids as contributing factors in carcinogenesis.

1979 • 276 citations

Methylation of the O⁶Position of Guanine in DNA is the Most Likely Initiating Event in Carcinogenesis by Methylating Agents

1984 • 236 citations

Transfection and expression of human O⁶-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents

1991 • 219 citations

Clinical trials with 1,3-bis(2-chloroethyl)-1-nitrosourea, NSC-409962.

1965 • 216 citations

Leukemia and Preleukemia after Adjuvant Treatment of Gastrointestinal Cancer with Semustine (Methyl-CCNU)

1983 • 211 citations

Genetics of cancer predisposition.

1987 • 199 citations

Mechanism of mutagenesis by O6-methylguanine

1984 • 191 citations

O6-methylguanine is a critical determinant of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone tumorigenesis in A/J mouse lung.

1991 • 183 citations

Alkylation of deoxyribonucleic acid in vivo in various organs of C57BL mice by the carcinogens N-methyl-N-nitrosourea, N-ethyl-N-nitrosourea and ethyl methanesulphonate in relation to induction of thymic lymphoma. Some applications of high-pressure liquid chromatography

1978 • 177 citations

A system in mouse liver for the repair of O⁶-methylguanine lesions in methylated DNA

1981 • 137 citations

Expression and cloning of complementary DNA for a human enzyme that repairs O6-methylguanine in DNA

1990 • 130 citations

Site-specific mutagenesis by O6-alkylguanines located in the chromosomes of mammalian cells: influence of the mammalian O6-alkylguanine-DNA alkyltransferase.

1989 • 129 citations

Toxicity, mutagenicity, and mutational spectra of N-ethyl-N-nitrosourea in human cell lines with different DNA repair phenotypes.

1991 • 115 citations

O6 alkylguanine-DNA alkyltransferase activity in human myeloid cells.

1985 • 113 citations

Requirement for the 3' flanking region of the bovine growth hormone gene for accurate polyadenylylation.

1984 • 109 citations

The β actin promoter

1989 • 89 citations

ras oncogenes and phenotypic staging in N-methylnitrosourea- and gamma-irradiation-induced thymic lymphomas in C57BL/6J mice.

1988 • 88 citations

DNA repair, oncogenes and carcinogenesis

1988 • 80 citations

Leukaemia complicating treatment for Hodgkin's disease: the experience of the British National Lymphoma Investigation.

1990 • 76 citations

Comparison of O-6-MethyIguanine DNA Methyltransferase (MGMT) mRNA Levels in Mer⁺ and Mer⁻ Human Tumor Cell Lines Containing the MGMT Gene by the Polymerase Chain Reaction Technique

1990 • 72 citations

Effect of O6-alkylguanine-DNA alkyltransferase on the frequency and spectrum of mutations induced by N-methyl-N′-nitro-N-nitrosoguanidine in the HPRT gene of diploid human fibroblasts

1991 • 70 citations

Methylation of DNA in various organs of c57b1 mice by a carcinogenic dose of N-methyl-N-nitrosourea and stability of some methylation products up to 18 hours

1975 • 68 citations

Toxicity, tissue changes, and tumor induction in inbred Swiss mice by methylnitrosamine and -amide compounds.

1970 • 64 citations

Comparison of the inactivation of mammalian and bacterial O⁶-alkylguanine-DNA alkyltransferases by O⁶-benzylguanine and O⁶-methylguanine

1991 • 55 citations

Modulation of nitrosourea resistance in human colon cancer by O6-methylguanine

1992 • 45 citations

DNA methyl-adduct dosimetry and O⁶-alkylguanine-DNA alkyl transferase activity determinations in rat mammary carcinogenesis by procarbazine and N-methylnitrosourea

1990 • 45 citations

Review: Diseases with DNA Damage-Processing Defects

1988 • 43 citations

Affinity purification and characterization of humanO⁶-alkylguanine-DNA aikyltransferase complexed with BCNU-treated, synthetic oligonudeotide

1989 • 41 citations

Thymomas Induced by Simple Alkylating Agents in C57BL/Cbi Mice: Kinetics of the Dose Response<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1980 • 38 citations

Measurements of DNA damage in Chinese hamster cells treated with equitoxic and equimutagenic doses of nitrosoureas.

1978 • 36 citations

Isolation and characterization of cDNA and genomic sequences for mouse O⁶-methylguanine-DNA methyltransferase

1992 • 36 citations

Depletion of O⁶-methylguanine-DNA-methyltransferase in human fibroblasts increases the mutagenic response to N-methyl-N'-nitro-N-nitrosoguanidine

1985 • 34 citations

Repair of O6-alkylguanine during DNA synthesis in murine bone marrow hematopoietic precursors.

1987 • 32 citations

O6-methylguanine methyltransferase activity and sensitivity of Japanese tumor cell strains to 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)- 3-nitrosourea hydrochloride.

1987 • 32 citations

Hormonal regulation of chimeric genes containing the phosphoenolpyruvate carboxykinase promoter regulatory region in hepatoma cells infected by murine retroviruses.

1988 • 30 citations

Heterogeneity in chromosome damage and repair rates after bleomycin in ataxia telangiectasia cells.

1988 • 28 citations

Enhanced repair of O6-methylguanine DNA adducts in the liver of transgenic mice expressing the ada gene.

1991 • 26 citations

The role of O6-alkylguanine DNA alkyltransferase in limiting nitrosourea-induced sister chromatid exchanges in proliferating human lymphocytes.

1989 • 24 citations

N-Methyl-N-nitrosourea potentiation of cytogenetic damage induced by 1,3-bis(2-chloroethyl)-1-nitrosourea in normal human lymphocytes.

1985 • 16 citations

Repair and replication of DNA in rat and mouse tissues in relation to cancer induction by N-nitroso-N-alkyl-ureas

1984 • 16 citations

Malignant lymphomas and renal changes in Swiss mice given nitrosomethylurea

1967 • 15 citations

Spontaneous Lymphomas in SJL/J-(v<sup>+</sup>) Mice: Ecotropic and Dualtropic Virus Expression in Normal and Lymphomatous Tissues<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref>

1981 • 12 citations