Molecular Epidemiology of Human Cancer

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1995 • 2,115 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.

1991 • 1,946 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

Preferential Formation of Benzo[ a ]pyrene Adducts at Lung Cancer Mutational Hotspots in P53

1996 • 1,636 citations

A novel form of Epstein-Barr virus latency in normal B cells in vivo

1995 • 1,552 citations

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

1991 • 1,525 citations

Sunburn and p53 in the onset of skin cancer

1994 • 1,501 citations

Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa

1991 • 1,418 citations

Radiation-induced cell cycle arrest compromised by p21 deficiency

1995 • 1,249 citations

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.

1994 • 1,165 citations

Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen

1994 • 941 citations

Gain of function mutations in p53

1993 • 876 citations

UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells.

1984 • 874 citations

p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes

1994 • 857 citations

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.

1994 • 850 citations

p53: oncogene or anti-oncogene?

1990 • 812 citations

Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?

1993 • 799 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.

1994 • 666 citations

Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair

1994 • 657 citations

p53 modulation of TFIIH–associated nucleotide excision repair activity

1995 • 555 citations

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

1995 • 546 citations

Genetic Mechanisms of Tumor Suppression by the Human p53 Gene

1990 • 540 citations

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

1994 • 538 citations

Wild-type p53 binds to the TATA-binding protein and represses transcription.

1992 • 527 citations

Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.

1990 • 502 citations

Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes.

1993 • 482 citations

p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

1995 • 409 citations

Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest.

1996 • 385 citations

Inhibition of DNA replication factor RPA by p53

1993 • 380 citations

Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53.

1994 • 355 citations

Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus

1995 • 347 citations

UV and skin cancer: specific p53 gene mutation in normal skin as a biologically relevant exposure measurement.

1994 • 324 citations

The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway.

1996 • 318 citations

Mutations of p53 and ras genes in radon-associated lung cancer from uranium miners

1992 • 315 citations

Database of p53 gene somatic mutations in human tumors and cell lines: updated compilation and future prospects

1997 • 305 citations

Molecular Epidemiology: Insights Into Cancer Susceptibility, Risk Assessment, and Prevention

1996 • 304 citations

Structures of benzo(a)pyrene–nucleic acid adducts formed in human and bovine bronchial explants

1977 • 299 citations

Geographic Variation of p53 Mutational Profile in Nonmalignant Human Liver

1994 • 282 citations

Specific UV-induced mutation spectrum in the p53 gene of skin tumors from DNA-repair-deficient xeroderma pigmentosum patients.

1993 • 278 citations

Simian virus 40 large tumor antigen-immortalized normal human liver epithelial cells express hepatocyte characteristics and metabolize chemical carcinogens.

1993 • 237 citations

UV MUTAGENIC PHOTOPRODUCTS IN Escherichia coli AND HUMAN CELLS: A MOLECULAR GENETICS PERSPECTIVE ON HUMAN SKIN CANCER*

1988 • 236 citations

p53-catalyzed annealing of complementary single-stranded nucleic acids.

1993 • 225 citations

Aflatoxin B1-induced DNA adduct formation and p53 mutations in CYP450- expressing human liver cell lines

1997 • 217 citations

Restricted ultraviolet mutational spectrum in a shuttle vector propagated in xeroderma pigmentosum cells.

1986 • 215 citations

Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein.

1993 • 209 citations

The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation.

1995 • 188 citations

Molecular Epidemiology and the Genetics of Environmental Cancer

1991 • 187 citations

Functional interactions between p53 and the TFIIH complex are affected by tumour-associated mutations.

1996 • 172 citations

The specificity of p53 mutation spectra in sunlight induced human cancers

1995 • 161 citations

Recommendations on Predictive Testing for Germ Line p53 Mutations Among Cancer-Prone Individuals

1992 • 129 citations

An aflatoxin-associated mutational hotspot at codon 249 in the p53 tumor suppressor gene occurs in hepatocellular carcinomas from Mexico

1996 • 127 citations

Cooperative DNA binding of p53 with TFIID (TBP): a possible mechanism for transcriptional activation.

1993 • 124 citations

p53 mutations in lung cancers from non-smoking atomic-bomb survivors

1993 • 118 citations

Aberrations of p53 gene in human hepatocellular carcinoma from China

1993 • 115 citations

A DNA binding domain is contained in the C-terminus ofwild typep53 protein

1991 • 113 citations

The 1995 Walter Hubert Lecture - molecular epidemiology of human cancer: insights from the mutational analysis of the p53 tumour-suppressor gene

1996 • 111 citations

The p53 activation domain binds the TATA box-binding polypeptide in Holo-TFIID, and a neighboring p53 domain inhibits transcription.

1993 • 108 citations

Modulation of DNA Topoisomerase I Activity by p53

1996 • 103 citations

A tobacco-specific N-nitrosamine or cigarette smoke condensate causes neoplastic transformation of xenotransplanted human bronchial epithelial cells.

1992 • 102 citations

Gas1-Induced Growth Suppression Requires a Transactivation-Independent p53 Function

1995 • 97 citations

A direct effect of activated human p53 on nuclear DNA replication.

1995 • 87 citations

Comparison of ultraviolet irradiation-induced mutagenesis of the lacI gene in Escherichia coli and in human 293 cells

1989 • 69 citations

Protein or RNA synthesis inhibition induces apoptosis of mature human CD4+ T cell blasts

1993 • 58 citations

Carcinogenic polynuclear hydrocarbons bind to macromolecules in cultured human bronchi

1974 • 53 citations

Alterations in pancreatic and hepatic ultrastructure following acute cycloheximide intoxication

1968 • 45 citations

p53 Inhibits DNA Replication In Vitro in a DNA-Binding-Dependent Manner

1995 • 38 citations

Apoptosis Is Induced in BHK Cells by the tsBN462/13 Mutation in the CCG1/TAFII250 Subunit of the TFIID Basal Transcription Factor

1995 • 38 citations

Activation of chemical carcinogens by cultured human fetal liver, esophagus and stomach

1984 • 36 citations

Benzo[a]pyrene‐induced mutagenesis of p53 hot‐spot codons 248 and 249 in human hepatocytes

1995 • 30 citations

Invasive tumors derived from xenotransplanted, immortalized human cells after in vivo exposure to chemical carcinogens

1993 • 25 citations