O6-methylguanine-DNA methyltransferase activity and sensitivity to cyclophosphamide and cisplatin in human lung tumor xenografts

Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.

1990 • 460 citations

Induction of cyclophosphamide-resistance by aldehyde-dehydrogenase gene transfer

1996 • 253 citations

Retrospective study of the correlation between the DNA repair protein alkyltransferase and survival of brain tumor patients treated with carmustine.

1996 • 245 citations

Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea.

1996 • 236 citations

Transfection and expression of human O⁶-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents

1991 • 219 citations

Chemotherapy of non-small-cell lung cancer.

1985 • 148 citations

p53 is involved in regulation of the DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) by DNA damaging agents

1998 • 138 citations

O6-Alkylguanine-DNA alkyltransferase activity correlates with the therapeutic response of human rhabdomyosarcoma xenografts to 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea.

1985 • 137 citations

O6-Alkylguanine-DNA alkyltransferase and sensitivity to procarbazine in human brain-tumor xenografts

1989 • 122 citations

Wild-type p53 suppresses transcription of the human O6-methylguanine-DNA methyltransferase gene.

1996 • 95 citations

Nucleotide excision repair genes as determinants of cellular sensitivity to cyclophosphamide analogs

1996 • 93 citations

Human tumor xenografts as model for drug testing

1988 • 93 citations

O⁶‐methylguanine‐DNA methyltransferase activity in breast and brain tumors

1995 • 88 citations

Protective effect of O6-methylguanine-DNA methyltransferase (MGMT) on the cytotoxic and recombinogenic activity of different antineoplastic drugs

1996 • 75 citations

Variation in response of xenografts of colo-rectal carcinoma to chemotherapy

1978 • 74 citations

Deoxyribonucleic acid crosslinking by 4-hydroperoxycyclophosphamide in cyclophosphamide-sensitive and -resistant L1210 cells

1984 • 72 citations

Modulation of cyclophosphamide activity by O ? 6 -alkylguanine-DNA alkyltransferase

1999 • 57 citations

p53 mutations, O6-alkylguanine DNA alkyltransferase activity, and sensitivity to procarbazine in human brain tumors

1995 • 43 citations

O6-alkylguanine-DNA-alkyltransferase activity and nitrosourea sensitivity in human cancer cell lines

1992 • 36 citations

Immunocytochemical detection of a resistance-associated glycoprotein in tissue culture cells, ascites tumors and human tumor xenografts by Mab 265/F4.

1988 • 36 citations

Growth of human bronchial carcinomas in nude mice

1985 • 32 citations

Capacity of individual chronic lymphatic leukemia lymphocytes and leukemic blast cells for repair of O6-ethylguanine in DNA: relation to chemosensitivity in vitro and treatment outcome.

1994 • 21 citations

O6-Methylguanine-DNA Methyltransferase in Ovarian Malignancy and Its Correlation with Postoperative Response to Chemotherapy

1994 • 19 citations

Cyclophosphamide decreases O6-alkylguanine-DNA alkyltransferase activity in peripheral lymphocytes of patients undergoing bone marrow transplantation

1992 • 17 citations

Resistance mechanisms in human lung cancer.

1995 • 15 citations