Methylation ofO6-methylguanine-DNA methyltransferase gene is associated significantly withK-ras mutation, lymph node invasion, tumor staging, and disease free survival in patients with gastric carcinoma

TNM Classification of Malignant Tumors

1998 • 5,989 citations

High sensitivity mapping of methylated cytosines

1994 • 1,863 citations

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.

1999 • 1,252 citations

Possible Relevance of O–6 Alkylation of Deoxyguanosine to the Mutagenicity and Carcinogenicity of Nitrosamines and Nitrosamides

1969 • 949 citations

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.

2000 • 529 citations

Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer.

2000 • 522 citations

Structure, Function, and Inhibition of O6-Alkylguanine-DNA Alkyltransferase

1995 • 502 citations

Mechanisms of carcinogenesis induced by alkylating agents

1985 • 461 citations

TNM Classification of Malignant Tumors.5th ed

1998 • 455 citations

Methylation of Discrete Regions of the O⁶-Methylguanine DNA Methyltransferase (MGMT) CpG Island Is Associated with Heterochromatinization of the MGMT Transcription Start Site and Silencing of the Gene

1997 • 214 citations

Methylation hot spots in the 5' flanking region denote silencing of the O6-methylguanine-DNA methyltransferase gene.

1997 • 214 citations

DNA alkylation by the haloethylnitrosoureas: Nature of modifications produced and their enzymatic repair or removal

1990 • 213 citations

Suicide inactivation of the E. coli O6-methylguanine-DNA methyltransferase.

1982 • 178 citations

Base-pairing properties of O6-methylguanine in template DNA during in vitro DNA replication.

1984 • 133 citations

Detection of K-ras mutation in sputum by mutant-allele-specific amplification (MASA)

1993 • 131 citations

Correlation between O⁶-methylguanine-DNA-methyltransferase activity and resistance of human cells to the cytotoxic and mutagenic effect of N-methyl-N′-nitro-N-nitrosoguanidine

1984 • 119 citations

Activation of c-K-ras mutations in human gastrointestinal tumors

2000 • 109 citations

Molecular analysis of O6-substituted guanine-induced mutagenesis of ras oncogenes.

1989 • 103 citations

No evidence for point mutations in codons 12, 13, and 61 of the ras gene in a high-incidence area for esophageal and gastric cancers.

1990 • 92 citations

Four human carcinoma cell lines with novel mutations in position 12 of c-K-ras oncogene

1986 • 89 citations

Experimental evidence for inhibition of N-nitroso compound formation as a factor in the negative correlation between vitamin C consumption and the incidence of certain cancers.

1994 • 87 citations

O⁶-Methylguanine-DNA methyltransferase activity in human liver tumors

1991 • 86 citations

Detection of K-ras mutations in DNAs isolated from feces of patients with colorectal tumors by mutant-allele-specific amplification (MASA).

1995 • 86 citations

Surgical results in gastric cancer

1999 • 73 citations

Clinicopathologic significance of the K-ras gene codon 12 point mutation in stomach cancer. An analysis of 140 cases

1995 • 68 citations

Methylation of selected CpGs in the humanO6-methylguanine-DNA methyltransferase promoter region as a marker of gene silencing

1999 • 59 citations

P53 mutations in primary and metastatic tumors and circulating tumor cells from colorectal carcinoma patients.

2000 • 53 citations

Frequent overexpression, but not activation by point mutation, of ras genes in primary human gastric cancers

1987 • 47 citations

N-nitroso compound formation in human gastric juice.

1989 • 46 citations

KRAS mutations predict progression of preneoplastic gastric lesions.

1999 • 46 citations

The DNA repair protein O6-methylguanine-DNA methyltransferase protects against skin tumor formation induced by antineoplastic chloroethylnitrosourea.

1997 • 44 citations

Microsatellite Instability and K-ras Mutations in Gastric Adenomas, with Reference to Associated Gastric Cancers

1999 • 37 citations

Surgery in the management of soft tissue sarcoma

1989 • 34 citations

Gastric adenoma ? carcinoma sequence with special reference to p53 and Ki-ras gene alterations

1995 • 32 citations

Association between growth stimulation by phenobarbital and expression of cytochromes P450 1A1, 1A2, 2B1/2 and 3A1 in hepatic hyperplastic nodules in male F344 rats

1992 • 32 citations

Allelic losses of 17p, 5q, and 18q loci in diploid and aneuploid populations of multiploid colorectal carcinomas

2000 • 23 citations

High level, regulated expression of the chimeric P-enolpyruvate carboxykinase (GTP)-bacterial O6-alkylguanine-DNA alkyltransferase (ada) gene in transgenic mice.

1990 • 22 citations

Development of tumors in the glandular stomach of rats after oral administration of carcinogens

1976 • 22 citations

Mutagenesis and O⁶-ethylguanine levels in DNA from N-nitroso-N-ethylurea-treated Salmonella typhimurium: evidence for a high mutational efficiency of O⁶-ethylguanine

1984 • 21 citations

Experimental Gastric Cancers

1993 • 20 citations

Loss of heterozygosity of APC and DCC tumor suppressor genes in human sporadic colon cancer

1999 • 17 citations

K-ras and p53 mutations in DNA extracted from colonic epithelial cells exfoliated in faeces of patients with colorectal cancer

2000 • 17 citations

Mutation of ras oncogene in gastric adenocarcinoma: association with histological phenotype.

1997 • 14 citations

Detection of c-Ki-ras oncogene mutation in gastric adenomas with formalin-fixed, paraffin-embedded biopsy materials

1997 • 9 citations

Studies of a deuterium isotope effect in carcinogenesis by N-nitroso-N-alkylurethanes in rats

1982 • 9 citations

Increased drug resistance following retroviral gene transfer of a chimeric P-enolipyruvate carboxykinase (GTIP)-bacterial O⁶ alkylguanine-DNA alkyltransferase gene into NRK cells

1990 • 8 citations

Comparison of O⁶-methylguanine-DNA methyltransferase mRNA levels in Ha-ras mutated and non-mutated rat mammary tumors induced by N-methyl-N-nitrosourea

1994 • 5 citations

An approach to establishing N-nitroso compounds as the cause of gastric cancer.

1991 • 5 citations

[Detection of c-Ki-ras oncogene codon 12 point mutations in lung carcinoma, gastric carcinoma and hepatic carcinoma].

1996 • 2 citations

Deleted Work

1955 • 0 citations