A defect in a single allele of the Mlh1 gene causes dissociation of the killing and tumorigenic actions of an alkylating carcinogen in methyltransferase-deficient mice

de la Chapelle, A.

1997 • 3,184 citations

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

1993 • 2,282 citations

Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer

1994 • 2,071 citations

Mutation of a mutL Homolog in Hereditary Colon Cancer

1994 • 1,834 citations

MISMATCH REPAIR IN REPLICATION FIDELITY, GENETIC RECOMBINATION, AND CANCER BIOLOGY

1996 • 1,485 citations

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.

1999 • 1,252 citations

Possible Relevance of O–6 Alkylation of Deoxyguanosine to the Mutagenicity and Carcinogenicity of Nitrosamines and Nitrosamides

1969 • 949 citations

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

1995 • 785 citations

Genetic studies of the lac repressor

1977 • 500 citations

Persistence of O 6-Ethylguanine in Rat-Brain DNA: Correlation with Nervous System-Specific Carcinogenesis by Ethylnitrosourea

1974 • 495 citations

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

1993 • 445 citations

Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains

1980 • 371 citations

Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage

1993 • 361 citations

K-Ras is essential for the development of the mouse embryo

1997 • 353 citations

Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DMA mismatch repair

1998 • 351 citations

Comparison of O⁶-alkylguanine-DNA alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues

1986 • 277 citations

Structure of the human MLH1 locus and analysis of a large hereditary nonpolyposis colorectal carcinoma kindred for mlh1 mutations.

1995 • 219 citations

Graded methylation in the promoter and body of the O6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells.

1994 • 200 citations

Mutator Phenotypes Conferred by MLH1Overexpression and by Heterozygosity for mlh1Mutations

1999 • 186 citations

Molecular basis of HNPCC: Mutations of MMR genes

1997 • 184 citations

Repair of alkylated DNA in Escherichia coli. Physical properties of O6-methylguanine-DNA methyltransferase.

1982 • 172 citations

Mouse models for hereditary nonpolyposis colorectal cancer.

1998 • 162 citations

Tumorigenesis in Mlh1 and Mlh1/Apc1638N mutant mice.

1999 • 161 citations

Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes

1998 • 132 citations

Methylnitrosourea-induced tumorigenesis in MGMT gene knockout mice.

1997 • 130 citations

Eukaryotic mismatch repair: an update

1998 • 127 citations

ACCELERATED PAPER: Targeted disruption of the DNA repair methyltransferase gene renders mice hypersensitive to alkylating agent

1996 • 116 citations

Alkylation-induced apoptosis of embryonic stem cells in which the gene for DNA-repair, methyltransferase, had been disrupted by gene targeting

1997 • 95 citations

High incidence of nitrosamine-induced tumorigenesis in mice lacking DNA repair methyltransferase

1997 • 93 citations

ras oncogenes and phenotypic staging in N-methylnitrosourea- and gamma-irradiation-induced thymic lymphomas in C57BL/6J mice.

1988 • 88 citations

Organization and expression of the human gene for O6-methylguanine-DNA methyltransferase

1993 • 53 citations

DNA-repair methyltransferase as a molecular device for preventing mutation and cancer

1996 • 53 citations

Roles of transcription and repair in alkylation mutagenesis

1994 • 45 citations

Isolation and characterization of cDNA and genomic sequences for mouse O⁶-methylguanine-DNA methyltransferase

1992 • 36 citations

Intracellular localization and function of DNA repair methyltransferase in human cells

1994 • 33 citations

Mouse methyltransferase for repair of O⁶-methylguanine and O⁴-methylthymine in DNA

1995 • 30 citations

Requirement of the Pro-Cys-His-Arg sequence for O6-methylguanine-DNA methyltransferase activity revealed by saturation mutagenesis with negative and positive screening

1994 • 19 citations

Influence of sex and carcinogen treatment protocol on tumor latency and frequency of K-ras mutations in N-methyl-N-nitrosourea-induced lymphomas

1994 • 12 citations

Organization and Expression of the Mouse Gene for DNA Repair Methyltransferase

1996 • 11 citations