DNA repair gene O6-methylguanine-DNA methyltransferase: Promoter hypermethylation associated with decreased expression and G:C to A:T mutations ofp53 in brain tumors

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

1996 • 5,667 citations

Cancer statistics, 1999

1999 • 3,154 citations

A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands.

1992 • 3,099 citations

Inactivation of the DNA-Repair GeneMGMTand the Clinical Response of Gliomas to Alkylating Agents

2000 • 2,127 citations

A gene hypermethylation profile of human cancer.

2001 • 2,043 citations

Brain Tumors

2001 • 1,527 citations

Pathology of Tumors of the Nervous System.

1964 • 1,494 citations

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.

1999 • 1,252 citations

Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.

1990 • 736 citations

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.

2000 • 529 citations

Structure, Function, and Inhibition of O6-Alkylguanine-DNA Alkyltransferase

1995 • 502 citations

Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains

1980 • 371 citations

PTEN mutations in gliomas and glioneuronal tumors

1998 • 348 citations

Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis.

2001 • 319 citations

DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells

1980 • 315 citations

The p53 Gene and Protein in Human Brain Tumors

1994 • 303 citations

Genetic studies of the lac repressor

1977 • 293 citations

Methylation of O-6-methylguanine DNA methyltransferase characterizes a subset of colorectal cancer with low-level DNA microsatellite instability.

2001 • 254 citations

Comparison of bisulfite modification of 5-methyldeoxycytidine and deoxycytidine residues

1980 • 243 citations

Repair of DNA containing O ⁶ ‐alkylguanine

1992 • 241 citations

The Prevention of Thymic Lymphomas in Transgenic Mice by Human O ⁶ -Alkylguanine-DNA Alkyltransferase

1993 • 238 citations

Promoter methylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G:C -> A:T mutations of the TP53 tumor suppressor gene

2001 • 231 citations

Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma.

1998 • 214 citations

Methylation of Discrete Regions of the O⁶-Methylguanine DNA Methyltransferase (MGMT) CpG Island Is Associated with Heterochromatinization of the MGMT Transcription Start Site and Silencing of the Gene

1997 • 214 citations

O6-benzylguanine and its role in chemotherapy.

1997 • 214 citations

Methylation hot spots in the 5' flanking region denote silencing of the O6-methylguanine-DNA methyltransferase gene.

1997 • 214 citations

A Molecular Genetic Model of Astrocytoma Histopathology

1997 • 199 citations

O6-methylguanine-DNA methyltransferase activity in adult gliomas: relation to patient and tumor characteristics.

1998 • 147 citations

Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon

1995 • 130 citations

Loss of P16INK4 expression is frequent in high grade gliomas.

1995 • 120 citations

O6-methylguanine-DNA methyltransferase in human normal and tumor tissue from brain, lung, and ovary.

1991 • 115 citations

O(6)-Methylguanine-DNA methyltransferase promoter hypermethylation shifts the p53 mutational spectrum in non-small cell lung cancer.

2001 • 104 citations

A detailed analysis of K-ras point mutations in relation to tumor progression and survival in colorectal cancer patients

1996 • 102 citations

Comparison of O6-methylguanine-DNA methyltransferase activity in brain tumors and adjacent normal brain.

1993 • 101 citations

Promoter hypermethylation of MGMT is associated with protein loss in gastric carcinoma

2001 • 96 citations

Reduced lung tumorigenesis in human methylguanine DNAmethyltransferase transgenic mice achieved by expression of transgene within the target cell

1999 • 77 citations

Comparison of O-6-MethyIguanine DNA Methyltransferase (MGMT) mRNA Levels in Mer⁺ and Mer⁻ Human Tumor Cell Lines Containing the MGMT Gene by the Polymerase Chain Reaction Technique

1990 • 72 citations

Expression of the O6-methylguanine-DNA methyltransferase gene MGMT in MER+ and MER- human tumor cells.

1990 • 71 citations

Methylation of selected CpGs in the humanO6-methylguanine-DNA methyltransferase promoter region as a marker of gene silencing

1999 • 59 citations

Detection of Messenger RNA From O6-Methylguanine-DNA Methyltransferase Gene MGMT in Human Normal and Tumor Tissues

1992 • 43 citations

Molecular Epidemiology of Human Cancer

1998 • 42 citations

The role of mRNA stability and transcription in 0⁶-methylguanine DNA methyltransferase (MGMT) expression in Mer⁺ human tumor cells

1995 • 40 citations

p53 mutations and MDM-2 amplification in renal cell cancers.

1994 • 36 citations

Increased Sensitivity of Transforming Growth Factor (TGF) β1 Null Cells to Alkylating Agents Reveals a Novel Link between TGFβ Signaling and O 6-Methylguanine Methyltransferase Promoter Hypermethylation

2001 • 28 citations

Heterogeneous methylation of the O6-methylguanine-DNA methyltransferase promoter in immortalized IMR90 cell lines

2001 • 18 citations