Improvement of chemotherapy efficacy by inactivation of a DNA-repair pathway

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1991 • 8,402 citations

Inactivation of the DNA-Repair GeneMGMTand the Clinical Response of Gliomas to Alkylating Agents

2000 • 2,127 citations

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.

1999 • 1,252 citations

Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.

1990 • 736 citations

Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage

2002 • 723 citations

Clinical Relevance of MGMT in the Treatment of Cancer

2002 • 415 citations

DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma.

1998 • 413 citations

Experimental evaluation of potential anticancer agents VIII. Effects of certain nitrosoureas on intracerebral L1210 leukemia.

1963 • 369 citations

Correlation of tumor O6 methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bis-chloroethylnitrosourea: a Southwest Oncology Group study.

1998 • 300 citations

Retrospective study of the correlation between the DNA repair protein alkyltransferase and survival of brain tumor patients treated with carmustine.

1996 • 245 citations

Formation of the cross-link 1-[N3-deoxycytidyl),2-[N1-deoxyguanosinyl]ethane in DNA treated with N,N'-bis(2-chloroethyl)-N-nitrosourea.

1982 • 227 citations

Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma.

1998 • 214 citations

Phase II Trial of Carmustine Plus O⁶-Benzylguanine for Patients With Nitrosourea-Resistant Recurrent or Progressive Malignant Glioma

2002 • 191 citations

Sensitivity of human cell strains having different abilities to repair O6-methylguanine in DNA to inactivation by alkylating agents including chloroethylnitrosoureas.

1984 • 127 citations

O6-benzylguanine: a clinical trial establishing the biochemical modulatory dose in tumor tissue for alkyltransferase-directed DNA repair.

1999 • 127 citations

The delivery of BCNU to brain tumors

1999 • 116 citations

O6-methylguanine-DNA methyltransferase in human normal and tumor tissue from brain, lung, and ovary.

1991 • 115 citations

Phase I Trial of Carmustine Plus O6-Benzylguanine for Patients With Recurrent or Progressive Malignant Glioma

2000 • 112 citations

Phase I clinical and pharmacological study of O6-benzylguanine followed by carmustine in patients with advanced cancer.

2000 • 106 citations

Enhancement of Nitrosourea Activity in Medulloblastoma and Glioblastoma Multiforme

1992 • 102 citations

O6-Methylguanine-DNA methyltransferase in pretreatment tumour biopsies as a predictor of response to temozolomide in melanoma

1998 • 88 citations

Inactivation of O6-methylguanine-DNA methyltransferase and sensitization of human tumor cells to killing by chloroethylnitrosourea by O6-methylguanine as a free base.

1986 • 86 citations

O⁶-Methylguanine-DNA methyltransferase activity in human liver tumors

1991 • 86 citations

O6-benzylguanine enhances the sensitivity of a glioma xenograft with low O6-alkylguanine-DNA alkyltransferase activity to temozolomide and BCNU

1996 • 83 citations

O6-alkylguanine-DNA alkyltransferase depletion and regeneration in human peripheral lymphocytes following dacarbazine and fotemustine.

1991 • 73 citations

Synergistic efficacy of O6benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in a human colon cancer xenograft completely resistant to BCNU alone

1993 • 72 citations

Understanding and manipulating O6-methylguanine-DNA methyltransferase expression

1997 • 71 citations

Reduction of O6-alkylguanine-DNA alkyltransferase activity in HeLa cells treated with O6-alkylguanines.

1985 • 69 citations

O6-methylguanine formation, repair protein depletion and clinical outcome with a 4 hr schedule of temozolomide in the treatment of advanced melanoma: Results of a phase II study

2000 • 69 citations

Transfer of the E. coli O6-methyltransferase gene into repair-deficient human cells and restoration of cellular resistance to N-methyl-N′-nitro-N-nitrosoguanidine

1986 • 67 citations

Mismatch repair and differential sensitivity of mouse and human cells to methylating agents

1999 • 64 citations

Effect of O6-benzylguanine on the sensitivity of human colon tumor xenografts to 1,3-BIS(2-chloroethyl)-1-nitrosourea(BCNU)

1993 • 58 citations

Biological Consequences of Reactions with DNA: Role of Specific Lesions

1990 • 58 citations

Activity of O6-methylguanine-DNA methyltransferase in relation to p53 status and therapeutic response in ovarian cancer

1999 • 57 citations

Modulation of cyclophosphamide activity by O ? 6 -alkylguanine-DNA alkyltransferase

1999 • 57 citations

Chemosensitivity to triazene compounds and O6-alkylguanine-DNA alkyltransferase levels: Studies with blasts of leukaemic patients

1995 • 53 citations

O6-benzylguanine increases the sensitivity of human primary bone marrow cells to the cytotoxic effects of temozolomide.

1995 • 47 citations

O6-methylguanine-DNA methyltransferase activity and sensitivity to cyclophosphamide and cisplatin in human lung tumor xenografts

1998 • 46 citations

Phase I Study of Streptozocin- and Carmustine-Sequenced Administration in Patients With Advanced Cancer

1992 • 46 citations

Sequential administration of temozolomide and fotemustine: Depletion of O6-alkyl guanine-DNA transferase in blood lymphocytes and in tumours

1999 • 45 citations

Intracellular localization of human DNA repair enzyme methylguanine-DNA methyltransferase by antibodies and its importance.

1992 • 40 citations

Sequential administration of varying doses of dacarbazine and fotemustine in advanced malignant melanoma

1993 • 40 citations

O⁶-Methylguanine-DNA methyltransferase activity in human tumors

1992 • 39 citations

Monosaccharide-Linked Inhibitors of O⁶-Methylguanine-DNA Methyltransferase (MGMT): Synthesis, Molecular Modeling, and Structure−Activity Relationships

2001 • 39 citations

Relationship between O6-methylguanine-DNA methyltransferase levels and clinical response induced by chloroethylnitrosourea therapy in glioma patients.

1999 • 38 citations

Differential inactivation of mammalian and Escherichia coli O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine

1994 • 37 citations

Carmustine and streptozocin in refractory melanoma: an attempt at modulation of O-alkylguanine-DNA-alkyltransferase.

1996 • 34 citations

Expression of the E. coli O⁶-methylguanine-methylphosphotriester methyltransferase gene in mammalian cells

1986 • 31 citations

O⁶‐Methylguanine‐DNA Methyltransferase (MGMT) as a Determinant of Resistance to Camptothecin Derivatives

2002 • 29 citations

Modulation of O6-alkylguanine-DNA alkyltransferase-mediated carmustine resistance using streptozotocin: a phase I trial.

1992 • 26 citations

Hypersensitivity of human tumor xenografts lacking O⁶-alkylguanine-DNA alkyltransferase to the anti-tumor agent 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea

1989 • 25 citations

Genetic Chemoprotection with Mutant O6-Alkylguanine-DNA-Alkyltransferases

2002 • 25 citations

Changes in O⁶-methylguanine-DNA methyltransferase expression during immortalization of cloned human fibroblasts

1996 • 24 citations

Inter- and intracellular heterogeneity of O⁶-alkylguanine-DNA alkyltransferase expression in human brain tumours: possible significance in nitrosourea therapy

1996 • 23 citations

O6-Methylguanine-DNA Methyltransferase in Ovarian Malignancy and Its Correlation with Postoperative Response to Chemotherapy

1994 • 19 citations

Expression of the O6-alkylguanine-DNA alkyltransferase gene is elevated in human breast tumor cells.

1998 • 15 citations

Immunohistochemical analysis of DNA mismatch repair protein and O6-methylguanine-DNA methyltransferase in melanoma metastases in relation to clinical response to DTIC-based chemotherapy

2002 • 14 citations

Deleted Work

1955 • 0 citations