Inactivation of the DNA repair gene O⁶‐methylguanine‐DNA methyltransferase by promoter hypermethylation and its relationship to aflatoxin B₁‐DNA adducts and p53 mutation in hepatocellular carcinoma

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

1996 • 5,667 citations

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

1997 • 1,960 citations

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.

1999 • 1,252 citations

DNA methylation, methyltransferases, and cancer

2001 • 725 citations

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.

2000 • 529 citations

Amplification and expression of the human cyclin D gene in esophageal cancer.

1992 • 411 citations

Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis.

2001 • 319 citations

Genetic studies of the lac repressor

1977 • 293 citations

Hypermethylation of the DNA Repair Gene O6-Methylguanine DNA Methyltransferase and Survival of Patients With Diffuse Large B-Cell Lymphoma

2002 • 289 citations

Comparison of O⁶-alkylguanine-DNA alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues

1986 • 277 citations

Repair of DNA containing O ⁶ ‐alkylguanine

1992 • 241 citations

Promoter methylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G:C -> A:T mutations of the TP53 tumor suppressor gene

2001 • 231 citations

Methylation hot spots in the 5' flanking region denote silencing of the O6-methylguanine-DNA methyltransferase gene.

1997 • 214 citations

Methylation of Discrete Regions of the O⁶-Methylguanine DNA Methyltransferase (MGMT) CpG Island Is Associated with Heterochromatinization of the MGMT Transcription Start Site and Silencing of the Gene

1997 • 214 citations

Graded methylation in the promoter and body of the O6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells.

1994 • 200 citations

The global burden of cancer

1998 • 186 citations

p53 mutations, chronic hepatitis B virus infection, and aflatoxin exposure in hepatocellular carcinoma in Taiwan.

1997 • 172 citations

Carcinogens preferentially bind at methylated CpG in the p53 mutational hot spots.

1998 • 144 citations

DNA methylation and the association between genetic and epigenetic changes: relation to carcinogenesis

1997 • 140 citations

High frequency of promoter hypermethylation of RASSF1A and p16 and its relationship to aflatoxin B₁–DNA adduct levels in human hepatocellular carcinoma

2002 • 124 citations

O6-methylguanine-DNA methyltransferase in human normal and tumor tissue from brain, lung, and ovary.

1991 • 115 citations

O(6)-Methylguanine-DNA methyltransferase promoter hypermethylation shifts the p53 mutational spectrum in non-small cell lung cancer.

2001 • 104 citations

Comparison of O6-methylguanine-DNA methyltransferase activity in brain tumors and adjacent normal brain.

1993 • 101 citations

Promoter hypermethylation of MGMT is associated with protein loss in gastric carcinoma

2001 • 96 citations

O⁶-Methylguanine-DNA methyltransferase activity in human liver tumors

1991 • 86 citations

A specific CpG methylation pattern of theMGMT promoter region associated with reduced MGMT expression in primary colorectal cancers

1999 • 78 citations

Quantitative immunohistochemical estimates of O6-alkylguanine-DNA alkyltransferase expression in normal and malignant human colon.

1996 • 45 citations

Detection of Messenger RNA From O6-Methylguanine-DNA Methyltransferase Gene MGMT in Human Normal and Tumor Tissues

1992 • 43 citations

Immunoaffinity purification of human O6-alkylguanine-DNA alkyltransferase using newly developed monoclonal antibodies.

1990 • 42 citations

Smoking-related increase of O6-methylguanine-DNA methyltransferase expression in human lung carcinomas

1998 • 41 citations

Chemical carcinogen-induced decreases in genomic 5-methyldeoxycytidine content of normal human bronchial epithelial cells.

1987 • 40 citations

O⁶-Methylguanine-DNA methyltransferase activity in human tumors

1992 • 39 citations

Association between growth stimulation by phenobarbital and expression of cytochromes P450 1A1, 1A2, 2B1/2 and 3A1 in hepatic hyperplastic nodules in male F344 rats

1992 • 32 citations

Smoking-related increase in O⁶-alkylguanine-DNA alkyltransferase activity in human lung tissue

1994 • 28 citations

Determinants of O6-alkylguanine-DNA alkyltransferase activity in human colon cancer.

1995 • 22 citations

Deleted Work

1955 • 0 citations