Activation of human O6-methylguanine-DNA methyltransferase gene by glucocorticoid hormone

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Cancer: Principles and Practice of Oncology.

1991 • 8,402 citations

DNA Repair and Mutagenesis

2006 • 4,725 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

MOLECULAR MECHANISMS OF ACTION OF STEROID/THYROID RECEPTOR SUPERFAMILY MEMBERS

1994 • 2,875 citations

DNA repair and mutagenesis

1996 • 2,289 citations

Cancer: Principles and Practice of Oncology.

1988 • 1,907 citations

Transcription Factor Interactions: Selectors of Positive or Negative Regulation from a Single DNA Element

1990 • 1,326 citations

Site-directed mutagenesis of virtually any plasmid by eliminating a unique site

1992 • 1,089 citations

Molecular Biology of Mutagens and Carcinogens

1983 • 803 citations

A High-Efficiency HeLa Cell Nuclear Transcription Extract

1988 • 612 citations

Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains

1980 • 371 citations

DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells

1980 • 315 citations

Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanine.

1990 • 292 citations

Mechanism of dexamethasone suppression of brain tumor-associated vascular permeability in rats. Involvement of the glucocorticoid receptor and vascular permeability factor.

1996 • 250 citations

The progesterone receptor stimulates cell-free transcription by enhancing the formation of a stable preinitiation complex

1990 • 223 citations

Methylation of Discrete Regions of the O⁶-Methylguanine DNA Methyltransferase (MGMT) CpG Island Is Associated with Heterochromatinization of the MGMT Transcription Start Site and Silencing of the Gene

1997 • 214 citations

DNA alkylation by the haloethylnitrosoureas: Nature of modifications produced and their enzymatic repair or removal

1990 • 213 citations

Mechanism of mutagenesis by O6-methylguanine

1984 • 191 citations

Multiple ribosomal RNA cleavage pathways in mammalian cells

1981 • 190 citations

Regulation of Repair of Alkylation Damage in Mammalian Genomes

1993 • 164 citations

Characterization of the promoter region of the human O⁶-methylguanine-DNA methyltransferase gene

1991 • 142 citations

Inducibility of the DNA Repair Gene Encoding O⁶-Methylguanine- DNA Methyltransferase in Mammalian Cells by DNA-Damaging Treatments

1991 • 138 citations

O6-Alkylguanine-DNA alkyltransferase activity correlates with the therapeutic response of human rhabdomyosarcoma xenografts to 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea.

1985 • 137 citations

Cross-linking of DNA induced by chloroethyinitrosourea is prevented by O⁶-methyiguanine-DNA methyttransferase

1983 • 137 citations

Base-pairing properties of O6-methylguanine in template DNA during in vitro DNA replication.

1984 • 133 citations

O6-Alkylguanine-DNA alkyltransferase and sensitivity to procarbazine in human brain-tumor xenografts

1989 • 122 citations

Induction of the alkyltransferase (MGMT) gene by DNA damaging agents and the glucocorticoid dexamethasone and comparison with the response of base excision repair genes

1996 • 121 citations

Inducibility of the DNA repair gene encoding O6-methylguanine-DNA methyltransferase in mammalian cells by DNA-damaging treatments.

1991 • 111 citations

A simplified assay for O⁶-methylguanine-DNA methyltransferase activity and its application to human neoplastic and non-neoplastic tissues

1984 • 104 citations

Recombinant human glucocorticoid receptor induces transcription of hormone response genes in vitro.

1990 • 78 citations

Negative Regulation of the Major Human AP-Endonuclease, a Multifunctional Protein^,

1996 • 74 citations

Comparison of O-6-MethyIguanine DNA Methyltransferase (MGMT) mRNA Levels in Mer⁺ and Mer⁻ Human Tumor Cell Lines Containing the MGMT Gene by the Polymerase Chain Reaction Technique

1990 • 72 citations

Role of O6-methylguanine-DNA methyltransferase in the resistance of pancreatic tumors to DNA alkylating agents.

1997 • 58 citations

O6-Methylguanine-DNA methyltransferase in human cells

1984 • 58 citations

Aberrant Silencing of the CpG Island-Containing Human O⁶-Methylguanine DNA Methyltransferase Gene Is Associated with the Loss of Nucleosome-Like Positioning

1997 • 58 citations

Organization and expression of the human gene for O6-methylguanine-DNA methyltransferase

1993 • 53 citations

DNA-protein interactions : principles and protocols

1994 • 48 citations

Regulation of in vitro transcription by progesterone receptor. Characterization and kinetic studies.

1990 • 46 citations

Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O6-alkylguanine-DNA alkyltransferase and N,N′-bis(2-chloroethyl)-N-nitrosourea

1995 • 45 citations

Age-dependent modulation of tissue-specific repair activity for 3-methyladenine and O6-methylguanine in DNA in inbred mice

1989 • 41 citations

O6-methylguanine-DNA methyltransferase in human fetal tissues: fetal and maternal factors.

1987 • 34 citations

Heterogeneity of O6-alkylguanine-DNA alkyltransferase activity in peripheral blood lymphocytes: relationship between this activity in lymphocytes and in lymphoblastoid lines from normal controls and from patients with Hodgkin's disease or non-Hodgkin's lymphoma.

1989 • 19 citations

Differential sensitivity of human and mouse alkyltransferase to O6-benzylguanine using a transgenic model.

1996 • 18 citations

Chemotherapy for malignant brain tumors

1990 • 16 citations

DNase I Footprinting

2003 • 12 citations